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  1. 16401
    “…METHODS: This randomised, double-blind, placebo-controlled, multicentre phase 3 trial was performed at 46 hospitals in the Netherlands, Germany, France, Belgium, Russia, Brazil, Peru, Mexico, and South Africa. Participants aged 18 years or older who were receiving invasive mechanical ventilation, but not more than 48 h after intubation at time of first infusion, had a PaO(2)/FiO(2) ratio of 60–200 mm Hg, and a confirmed SARS-CoV-2 infection with any variant in the past 14 days were eligible for this study. …”
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    Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
  2. 16402
    “…METHODS: We did an unmasked post-hoc immunogenicity analysis after the first and second doses of AZD1222 in a randomised, placebo-controlled, phase 1b–2a study done in seven locations in South Africa. AZD1222 recipients who were HIV-uninfected, were stratified into baseline seropositive or seronegative groups using the serum anti-nucleocapsid (anti-N) immunoglobulin G (IgG) electroluminescence immunoassay to establish SARS-CoV-2 infection before the first dose of AZD1222. …”
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    Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b–2a trial
  3. 16403
    “…Adults aged at least 18 years without previous COVID-19 vaccination at public and private medical practices and hospitals in Belgium, Brazil, Colombia, France, Germany, the Philippines, South Africa, Spain, the UK, and the USA were randomly assigned 1:1 via a computer algorithm to receive intramuscularly administered Ad26.COV2.S as a primary dose plus a booster dose at 2 months or two placebo injections 2 months apart. …”
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    Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial
  4. 16404
    “…Children weighing less than 14 kg starting first-line or second-line ART were enrolled in seven HIV treatment centres in South Africa, Uganda, and Zimbabwe. Randomisation, which was computer generated by the trial statistician, was stratified by first-line or second-line ART and three weight bands. …”
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    Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial
  5. 16405
    “…RESULTS: This final analysis includes 579 women and 572 infants in 4 countries (Argentina, Chile, South Africa, and the US); 462 (79.8%) women received RSVpreF. …”
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    91. Establishing Proof of Concept for a Bivalent RSVpreF Subunit Vaccine for Maternal Immunization
  6. 16406
    “…There were gaps in the geographical spread for both HICs and LMICs and some countries were more dominant, such as the USA for HICs, South Africa for middle‐income countries, and Uganda for low‐income countries. …”
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    Healthcare workers' perceptions and experiences of primary healthcare integration: a scoping review of qualitative evidence
  7. 16407
    “…RENOIR is a phase 3 global, multicenter, randomized, double-blinded, placebo-controlled study evaluating vaccine efficacy (VE) in adults ≥60 years of age during two RSV seasons in Northern and Southern Hemisphere countries (Argentina, Canada, Finland, Japan, Netherlands, South Africa, and USA) (NCT05035212). VE at the end of the first RSV surveillance season (EOS1) against ARI-RSV, Lower Respiratory Tract Illness (LRTI)-RSV with ≥2 symptoms (2+ LRTI-RSV), and LRTI-RSV with ≥3 symptoms (3+ LRTI-RSV) was 62.2% (44.4, 74.9), 65.1% (35.9, 82.0), and 88.9% (53.6, 98.7), respectively. …”
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    1634. Respiratory Syncytial Virus-Associated Health Care Utilization in the Pivotal Phase 3 Trial RSV Vaccine Efficacy Study In Older Adults Immunized Against RSV Disease (RENOIR)
  8. 16408
    “…METHODS: We did a multicentre, randomised, double-blind, placebo-controlled, adaptive design, phase 3 trial at 33 centres (private or public hospitals, clinical research centres, or Centre for Disease Control and Prevention) in four countries (Colombia, Philippines, South Africa, and Viet Nam). Men and non-pregnant women (aged ≥18 years) were eligible if they had never been infected with SARS-CoV-2, and if they did not have a SARS-CoV-2 vaccination history at screening or if they had received at least one dose of other SARS-CoV-2 vaccines 6 months or longer before enrolment. …”
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    Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
  9. 16409
    por Karumbi, Jamlick, Garner, Paul
    Publicado 2015
    “…DOT versus self‐administered Six trials from South Africa, Thailand, Taiwan, Pakistan and Australia compared DOT with self‐administered therapy for treatment. …”
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    Directly observed therapy for treating tuberculosis
  10. 16410
    “…The remaining two trials, in general adult populations, were conducted in Timor‐Leste and South Africa. Sustained incentive programmes Only two trials have assessed whether material incentives and enablers can improve long‐term adherence and completion of treatment for active TB, and neither demonstrated a clear benefit (RR 1.04, 95% CI 0.97 to 1.14; two trials, 4356 participants; low quality evidence). …”
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    Incentives and enablers to improve adherence in tuberculosis
  11. 16411
    “…The included trials were conducted in the USA (12 trials), Canada (one trial), Switzerland (one trial), Uganda (one trial), and South Africa (one trial), and published between 1996 and 2016. …”
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    Psychosocial group interventions to improve psychological well‐being in adults living with HIV
  12. 16412
    “…Nine studies were conducted in sub‐Saharan Africa (Ethiopia, Nigeria, South Africa, Zambia, and Zimbabwe), six in Asia (Bangladesh, Cambodia, India, Nepal, and Pakistan), and two in South America (Brazil and Colombia); which are all high tuberculosis prevalence areas. …”
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    Interventions to increase tuberculosis case detection at primary healthcare or community‐level services
  13. 16413
    “…HIV Prevention Trials Network study 077 (HPTN 077) evaluated the safety, tolerability, and pharmacokinetics of CAB LA in HIV-uninfected males and females at 8 sites in Brazil, Malawi, South Africa, and the United States. METHODS AND FINDINGS: HPTN 077 was a double-blind, placebo-controlled phase 2a trial. …”
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    Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial
  14. 16414
    por Bravo, Lulu, Smolenov, Igor, Han, Htay Htay, Li, Ping, Hosain, Romana, Rockhold, Frank, Clemens, Sue Ann Costa, Roa, Camilo, Borja-Tabora, Charissa, Quinsaat, Antoinette, Lopez, Pio, López-Medina, Eduardo, Brochado, Leonardo, Hernández, Eder A, Reynales, Humberto, Medina, Tatiana, Velasquez, Hector, Toloza, Leonardo Bautista, Rodriguez, Edith Johana, de Salazar, Dora Ines Molina, Rodríguez, Camilo A, Sprinz, Eduardo, Cerbino-Neto, José, Luz, Kleber Giovanni, Schwarzbold, Alexandre Vargas, Paiva, Maria Sanali, Carlos, Josefina, Montellano, May Emmeline B, de Los Reyes, Mari Rose A, Yu, Charles Y, Alberto, Edison R, Panaligan, Mario M, Salvani-Bautista, Milagros, Buntinx, Erik, Hites, Maya, Martinot, Jean-Benoit, Bhorat, Qasim E, Badat, Aysha, Baccarini, Carmen, Hu, Branda, Jurgens, Jaco, Engelbrecht, Jan, Ambrosino, Donna, Richmond, Peter, Siber, George, Liang, Joshua, Clemens, Ralf
    Publicado 2022
    “…METHODS: This ongoing phase 2 and 3 double-blind, placebo-controlled trial was done in adults aged 18 years and older who were in good health or with a stable chronic health condition, at 31 sites in five countries (Belgium, Brazil, Colombia, Philippines, and South Africa). The participants were randomly assigned 1:1 using a centralised internet randomisation system to receive two 0·5 mL intramuscular doses of SCB-2019 (30 μg, adjuvanted with 1·50 mg CpG-1018 and 0·75 mg alum) or placebo (0·9% sodium chloride for injection supplied in 10 mL ampoules) 21 days apart. …”
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    Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial
  15. 16415
    por Rimmer, Michael P, Howie, Ruth A, Anderson, Richard A, Barratt, Christopher L R, Barnhart, Kurt T, Beebeejaun, Yusuf, Bertolla, Ricardo Pimenta, Bhattacharya, Siladitya, Björndahl, Lars, Bortoletto, Pietro, Brannigan, Robert E, Cantineau, Astrid E P, Caroppo, Ettore, Collura, Barbara L, Coward, Kevin, Eisenberg, Michael L, De Geyter, Christian, Goulis, Dimitrios G, Henkel, Ralf R, Ho, Vu N A, Hussein, Alayman F, Huyser, Carin, Kadijk, Jozef H, Kamath, Mohan S, Khashaba, Shadi, Kobori, Yoshitomo, Kopeika, Julia, Kucuk, Tansu, Luján, Saturnino, Matsaseng, Thabo Christopher, Mathur, Raj S, McEleny, Kevin, Mitchell, Rod T, Mol, Ben W, Murage, Alfred M, Ng, Ernest H Y, Pacey, Allan, Perheentupa, Antti H, Du Plessis, Stefan, Rives, Nathalie, Sarris, Ippokratis, Schlegel, Peter N, Shabbir, Majid, Śmiechowski, Maciej, Subramanian, Venkatesh, Sunkara, Sesh K, Tarlarzis, Basil C, Tüttelmann, Frank, Vail, Andy, van Wely, Madelon, Vazquez-Levin, Mónica H, Vuong, Lan N, Wang, Alex Y, Wang, Rui, Zini, Armand, Farquhar, Cindy M, Niederberger, Craig, Duffy, James M N
    Publicado 2022
    “…Attendance at Fertility 2020 and Roadshow South Africa by Ralf Henkel was funded by LogixX Pharma Ltd. …”
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    Protocol for developing a core outcome set for male infertility research: an international consensus development study
  16. 16416
    “…During April 4–18, we detected an increasing trend of pool positivity among travelers on South African flights, detecting one of the first US-reported BA.4 sub-lineages consistent with early surge of cases in South Africa. Weekly pooled positivity for travelers on South African flights aligned with World Health Organization (WHO)-reported 7-day COVID-19 incidence rates over the same period (Figure 3). …”
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    1525. The Impact of Traveler-Based Genomic Surveillance on SARS-CoV-2 Variant Detection in Arriving International Air Travelers– United States, November 29, 2021-April 24, 2022
  17. 16417
    “…Between 1990 and 2007, 15 southern white (Ceratotherium simum simum) and black (Diceros bicornis) rhinoceroses on average were killed illegally every year in South Africa. Since 2007 illegal killing of southern white rhinoceros for their horn has escalated to >950 individuals/year in 2013. …”
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    Identification of policies for a sustainable legal trade in rhinoceros horn based on population projection and socioeconomic models
  18. 16418
    “…Five trials were conducted in sub‐Saharan Africa (Malawi, South Africa, Tanzania, Zimbabwe, and Kenya), one in Latin America (Chile), and two in Europe (England and Scotland). …”
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    School‐based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents
  19. 16419
    “…BACKGROUND: A monovalent, parenteral, subunit rotavirus vaccine was well tolerated and immunogenic in adults in the USA and in toddlers and infants in South Africa, but elicited poor responses against heterotypic rotavirus strains. …”
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    Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial
  20. 16420
    “…METHODS: In this multicentre, open-label, partially randomised, phase 2b trial, we prospectively recruited patients with drug-susceptible or rifampicin-resistant pulmonary tuberculosis from seven sites in South Africa, two in Tanzania, and one in Uganda. Patients aged 18 years or older with sputum smear grade 1+ or higher were eligible for enrolment, and a molecular assay (GeneXpert or MTBDRplus) was used to confirm the diagnosis of tuberculosis and to distinguish between drug-susceptible and rifampicin-resistant tuberculosis. …”
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    Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial
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