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19721por Aalseth, C.E., Abdelhakim, S., Acerbi, F., Agnes, P., Ajaj, R., Albuquerque, I.F.M., Alexander, T., Alici, A., Alton, A.K., Amaudruz, P., Ameli, F., Anstey, J., Antonioli, P., Arba, M., Arcelli, S., Ardito, R., Arnquist, I.J., Arpaia, P., Asner, D.M., Asunskis, A., Ave, M., Back, H.O., Barrado Olmedo, A., Batignani, G., Bisogni, M.G., Bocci, V., Bondar, A., Bonfini, G., Bonivento, W., Borisova, E., Bottino, B., Boulay, M.G., Bunker, R., Bussino, S., Buzulutskov, A., Cadeddu, M., Cadoni, M., Caminata, A., Canci, N., Candela, A., Cantini, C., Caravati, M., Cariello, M., Carnesecchi, F., Carpinelli, M., Castellani, A., Castello, P., Catalanotti, S., Cataudella, V., Cavalcante, P., Cavazza, D., Cavuoti, S., Cebrian, S., Cela Ruiz, J.M., Celano, B., Cereseto, R., Cheng, W., Chepurnov, A., Cicalò, C., Cifarelli, L., Citterio, M., Cocco, A.G., Cocco, V., Colocci, M., Consiglio, L., Cossio, F., Covone, G., Crivelli, P., D'Antone, I., D'Incecco, M., D'Urso, D., Da Rocha Rolo, M.D., Dadoun, O., Daniel, M., Davini, S., De Candia, A., De Cecco, S., De Deo, M., De Falco, A., De Filippis, G., De Gruttola, D., De Guido, G., De Rosa, G., Dellacasa, G., Demontis, P., DePaquale, S., Derbin, A.V., Devoto, A., Di Eusanio, F., Di Noto, L., Di Pietro, G., Di Stefano, P., Dionisi, C., Dolganov, G., Dordei, F., Downing, M., Edalatfar, F., Empl, A., Fernandez Diaz, M., Ferri, A., Filip, C., Fiorillo, G., Fomenko, K., Franceschi, A., Franco, D., Froudakis, G.E., Gabriele, F., Gabrieli, A., Galbiati, C., Garcia Abia, P., Gascón Fora, D., Gendotti, A., Ghiano, C., Ghisi, A., Giagu, S., Giampa, P., Giampaolo, R.A., Giganti, C., Giorgi, M.A., Giovanetti, G.K., Gligan, M.L., Gola, A., Gorchakov, O., Grab, M., Graciani Diaz, R., Granato, F., Grassi, M., Grate, J.W., Grigoriev, G.Y., Grobov, A., Gromov, M., Guan, M., Guerra, M.B.B., Guerzoni, M., Gulino, M., Haaland, R.K., Hackett, B.R., Hallin, A., Harrop, B., Hoppe, E.W., Horikawa, S., Hosseini, B., Hubaut, F., Humble, P., Hungerford, E.V., Ianni, An., Ilyasov, A., Ippolito, V., Jillings, C., Keeter, K., Kendziora, C.L., Kim, S., Kochanek, I., Kondo, K., Kopp, G., Korablev, D., Korga, G., Kubankin, A., Kugathasan, R., Kuss, M., Kuźniak, M., La Commara, M., La Delfa, L., Lai, M., Langrock, S., Lebois, M., Lehnert, B., Levashko, N., Li, X., Liqiang, Q., Lissia, M., Lodi, G.U., Longo, G., López Manzano, R., Lussana, R., Luzzi, L., Machado, A.A., Machulin, I.N., Mandarano, A., Mapelli, L., Marcante, M., Margotti, A., Mari, S.M., Mariani, M., Maricic, J., Marinelli, M., Marras, D., Martínez, M., Martínez Morales, J.J., Martinez Rojas, A.D., Martoff, C.J., Mascia, M., Mason, J., Masoni, A., Mazzi, A., McDonald, A.B., Messina, A., Meyers, P.D., Miletic, T., Milincic, R., Moggi, A., Moioli, S., Monroe, J., Morrocchi, M., Mroz, T., Mu, W., Muratova, V.N., Murphy, S., Muscas, C., Musico, P., Nania, R., Napolitano, T., Navrer Agasson, A., Nessi, M., Nikulin, I., Oleinik, A., Oleynikov, V., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Palmas, S., Pandola, L., Pantic, E., Paoloni, E., Paternoster, G., Pavletcov, V., Pazzona, F., Peeters, S., Pegoraro, P.A., Pelczar, K., Pellegrini, L.A., Pellegrino, C., Pelliccia, N., Perotti, F., Pesudo, V., Picciau, E., Piemonte, C., Pietropaolo, F., Pocar, A., Pollman, T., Portaluppi, D., Poudel, S.S., Pralavorio, P., Price, D., Radics, B., Raffaelli, F., Ragusa, F., Razeti, M., Razeto, A., Regazzoni, V., Regenfus, C., Renshaw, A.L., Rescia, S., Rescigno, M., Retiere, F., Rignanese, L.P., Rivetti, A., Romani, A., Romero, L., Rossi, N., Rubbia, A., Sablone, D., Sala, P., Salatino, P., Samoylov, O., Sánchez García, E., Sanfilippo, S., Sant, M., Santone, D., Santorelli, R., Savarese, C., Scapparone, E., Schlitzer, B., Scioli, G., Segreto, E., Seifert, A., Semenov, D.A., Shchagin, A., Sheshukov, A., Siddhanta, S., Simeone, M., Singh, P.N., Skensved, P., Skorokhvatov, M.D., Smirnov, O., Sobrero, G., Sokolov, A., Sotnikov, A., Stainforth, R., Steri, A., Stracka, S., Strickland, V., Suffritti, G.B., Sulis, S., Suvorov, Y., Szelc, A.M., Tartaglia, R., Testera, G., Thorpe, T., Tonazzo, A., Tosi, A., Tuveri, M., Unzhakov, E.V., Usai, G., Vacca, A., Vázquez-Jáuregui, E., Verducci, M., Viant, T., Viel, S., Villa, F., Vishneva, A., Vogelaar, R.B., Wada, M., Wahl, J., Walding, J.J., Wang, H., Wang, Y., Westerdale, S., Wheadon, R.J., Williams, R., Wilson, J., Wojcik, Marcin, Wojcik, Mariusz, Wu, S., Xiao, X., Yang, C., Ye, Z., Zuffa, M., Zuzel, G.“…This will be carried out by the DArT in ArDM experiment, a small chamber made with extremely radio-pure materials that will be placed at the centre of the ArDM detector, in the Canfranc Underground Laboratory (LSC) in Spain. The ArDM LAr volume acts as an active veto for background radioactivity, mostly γ-rays from the ArDM detector materials and the surrounding rock. …”
Publicado 2020
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19722por Lopez-Perez, Juan Antonio“…A testbed was performed including a big number of heterogeneous hardware and software that involves a farm of 100 computers at CERN's computing center (lxboinc) together with 30 PCs from CIEMAT and 45 from schools from Extremadura (Spain). That required a preliminary study, development and creation of components of the Quattor software and configuration management tool to install and manage the lxboinc farm and it also involved the set up of a collaboration between the Spanish research centers and government and CERN. …”
Publicado 2008
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19723por CABRERA, Anatael“… Moreover, the approved </span><i><span style="font-size:14.7px;"><strong>AntiMatter-OTech</strong></span></i><span style="font-size:14.7px;"> project, funded by the EU-EIC (France, Germany, Spain) and UKRI (UK), will address the specific LiquidO’s performance demonstration within the same time scale while establishing a new experiment in fundamental physics called </span><i><span style="font-size:14.7px;"><strong>νCLOUD</strong></span></i><span style="font-size:14.7px;"> at Chooz, including the direct participation of EDF in neutrino-based innovation for the first time. …”
Publicado 2022
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19724por Annane, Djillali, Pittock, Sean J, Kulkarni, Hrishikesh S, Pickering, Brian W, Khoshnevis, Matt R, Siegel, Jason L, Powell, Charles A, Castro, Pedro, Fujii, Tomoko, Dunn, Derek, Smith, Keisha, Mitter, Sanjay, Kazani, Shamsah, Kulasekararaj, Austin“…METHODS: This phase 3, multicentre, open-label, randomised controlled trial (ALXN1210-COV-305) enrolled adult patients (aged ≥18 years) from 31 hospitals in France, Japan, Spain, the UK, and the USA. Eligible patients had a confirmed diagnosis of SARS-CoV-2 that required hospitalisation and either invasive or non-invasive mechanical ventilation, with severe pneumonia, acute lung injury, or acute respiratory distress syndrome confirmed by CT scan or x-ray. …”
Publicado 2023
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19725por Francia, P, Sclafani, M, Franco, P, Falasconi, G, Soto-Iglesias, D, Cigliese, B, Schiavo, M A, Parisi, V, Biagini, E, Musumeci, M B, Autore, C, Alderete, J, Marti-Almor, J, Penela, D, Berruezo, A“…METHODS: We analyzed CMR images, generated color-coded pixel signal intensity (PSI) maps based on LGE using the ADAS 3D LV software (Galgo Medical, Barcelona, Spain), and characterized hyper-enhanced areas as core zone, BZ or healthy tissue. …”
Publicado 2023
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19726por de Batlle, Jordi, Benítez, Ivan D, Moncusí-Moix, Anna, Androutsos, Odysseas, Angles Barbastro, Rosana, Antonini, Alessio, Arana, Eunate, Cabrera-Umpierrez, Maria Fernanda, Cea, Gloria, Dafoulas, George Ε, Folkvord, Frans, Fullaondo, Ane, Giuliani, Francesco, Huang, Hsiao-Ling, Innominato, Pasquale F, Kardas, Przemyslaw, Lou, Vivian W Q, Manios, Yannis, Matsangidou, Maria, Mercalli, Franco, Mokhtari, Mounir, Pagliara, Silvio, Schellong, Julia, Stieler, Lisa, Votis, Konstantinos, Currás, Paula, Arredondo, Maria Teresa, Posada, Jorge, Guillén, Sergio, Pecchia, Leandro, Barbé, Ferran, Torres, Gerard, Fico, Giuseppe“…RESULTS: Seven European countries were selected, covering Europe’s geographical and socioeconomic heterogeneity: Cyprus, Germany, Greece, Italy, Poland, Spain, and the United Kingdom. These were complemented by the following 3 Asian pilots: Hong Kong, Singapore, and Taiwan. …”
Publicado 2023
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19727por Meca-Lallana, José E., Prieto González, José M., Caminero Rodríguez, Ana B., Olascoaga Urtaza, Javier, Alonso, Ana M., Durán Ferreras, Eduardo, Espinosa, Raúl, Dotor, Julio, Romera, Mercedes, Ares Luque, Adrián, Pérez Ruiz, Domingo, Calles, Carmen, Hernández, Miguel A., Hervás García, Miguel, Mendoza Rodríguez, Amelia, Berdei Montero, Yasmina, Téllez, Nieves, Herrera Varó, Nicolás, Sotoca, Javier, Presas-Rodríguez, Silvia, Querol Gutierrez, Luis A., Hervás Pujol, Mariona, Batlle Nadal, Jordi, Martín Ozaeta, Gisela, Gubieras Lillo, Laura, Martínez Yélamos, Sergio, Ramió-Torrentà, Lluís, Mallada Frechin, Javier, Belenguer Benavides, Antonio, Gascón-Giménez, Francisco, Casanova, Bonaventura, Landete Pascual, Lamberto, Berenguer, Leticia, Navarro, Laura, Gómez Gutierrez, Montserrat, Durán, Carmen, Rodríguez Regal, Ana, Álvarez, Elena, García-Estévez, Daniel A., López Real, Ana M., Llaneza González, Miguel A., Marzo Sola, María E., Sánchez-Menoyo, José L., Oterino, Agustín, Villaverde González, Ramón, Castillo-Triviño, Tamara, Álvarez de Arcaya, Amaya, Llarena, Cristina“…METHODS: This prospective observational study in Spain included RRMS patients treated with teriflunomide for ≤ 4 weeks. …”
Publicado 2023
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19728por Estévez, Samuel, Buzón, Luis, Pousada, Guillermo, Tomé, Roberto Pedrero, Galera, Carlos, Sanz, Jose, Santos, Ignacio, Dueñas, Carlos, Cabello, Noemí, Martín, Cristina, Galindo, María José, Garcinuño, María Ángeles, Hernández, Cristina, Lebón, Gabriela, Fernández, Beatriz, Troya, Jesús“…RESULTS: The study population comprised 1315 persons from 11 centers in Spain, of whom 78.5% were men, and the median age was 51 [42.0 – 57.0] years. …”
Publicado 2023
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19729por Crous, P.W., Wingfield, M.J., Guarro, J., Cheewangkoon, R., van der Bank, M., Swart, W.J., Stchigel, A.M., Cano-Lira, J.F., Roux, J., Madrid, H., Damm, U., Wood, A.R., Shuttleworth, L.A., Hodges, C.S., Munster, M., de Jesús Yáñez-Morales, M., Zúñiga-Estrada, L., Cruywagen, E.M., de Hoog, G.S., Silvera, C., Najafzadeh, J., Davison, E.M., Davison, P.J.N., Barrett, M.D., Barrett, R.L., Manamgoda, D.S., Minnis, A.M., Kleczewski, N.M., Flory, S.L., Castlebury, L.A., Clay, K., Hyde, K.D., Maússe-Sitoe, S.N.D., Chen, Shuaifei, Lechat, C., Hairaud, M., Lesage-Meessen, L., Pawłowska, J., Wilk, M., Śliwińska-Wyrzychowska, A., Mętrak, M., Wrzosek, M., Pavlic-Zupanc, D., Maleme, H.M., Slippers, B., Mac Cormack, W.P., Archuby, D.I., Grünwald, N.J., Tellería, M.T., Dueñas, M., Martín, M.P., Marincowitz, S., de Beer, Z.W., Perez, C.A., Gené, J., Marin-Felix, Y., Groenewald, J.Z.“…Several species were also described from Thailand, namely: Chaetopsina pini and C. pinicola from Pinus spp., Myrmecridium thailandicum from reed litter, Passalora pseudotithoniae from Tithonia, Pallidocercospora ventilago from Ventilago, Pyricularia bothriochloae from Bothriochloa and Sphaerulina rhododendricola from Rhododendron. Novelties from Spain include Cladophialophora multiseptata, Knufia tsunedae and Pleuroascus rectipilus from soil and Cyphellophora catalaunica from river sediments. …”
Publicado 2013
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19730por Liu, Qin, Abba, Katharine, Alejandria, Marissa M, Sinclair, David, Balanag, Vincent M, Lansang, Mary Ann D“…For people on TB prophylaxis, clinic attendance was higher with a policy of pre‐appointment phone‐calls (63% versus 48%; RR 1.30, 95% CI 1.07 to 1.59, one trial (USA), 536 participants); and attendance at the final clinic was higher with regular three‐monthly phone‐calls or nurse visits (93% versus 65%, one trial (Spain), 318 participants). For people undergoing screening for TB, three trials of pre‐appointment phone‐calls found little or no effect on the proportion of people returning to clinic for the result of their skin test (three trials, 1189 participants, low quality evidence), and two trials found little or no effect with take home reminder cards (two trials, 711 participants). …”
Publicado 2014
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19731por Crous, P.W., Wingfield, M.J., Guarro, J., Hernández-Restrepo, M., Sutton, D.A., Acharya, K., Barber, P.A., Boekhout, T., Dimitrov, R.A., Dueñas, M., Dutta, A.K, Gené, J., Gouliamova, D.E., Groenewald, M., Lombard, L., Morozova, O.V., Sarkar, J., Smith, M.Th., Stchigel, A.M., Wiederhold, N.P., Alexandrova, A.V., Antelmi, I., Armengol, J., Barnes, I., Cano-Lira, J.F., Castañeda Ruiz, R.F., Contu, M., Courtecuisse, Pr.R., da Silveira, A.L., Decock, C.A., de Goes, A., Edathodu, J., Ercole, E., Firmino, A.C., Fourie, A., Fournier, J., Furtado, E.L., Geering, A.D.W., Gershenzon, J., Giraldo, A., Gramaje, D., Hammerbacher, A., He, X.-L., Haryadi, D., Khemmuk, W., Kovalenko, A.E., Krawczynski, R., Laich, F., Lechat, C., Lopes, U.P., Madrid, H., Malysheva, E.F., Marín-Felix, Y., Martín, M.P., Mostert, L., Nigro, F., Pereira, O.L., Picillo, B., Pinho, D.B., Popov, E.S., Rodas Peláez, C.A., Rooney-Latham, S., Sandoval-Denis, M., Shivas, R.G., Silva, V., Stoilova-Disheva, M.M., Telleria, M.T., Ullah, C., Unsicker, S.B., van der Merwe, N.A., Vizzini, A., Wagner, H.-G., Wong, P.T.W., Wood, A.R., Groenewald, J.Z.“…(South Africa), Neodevriesia pakbiae, Phaeophleospora hymenocallidis and Phaeophleospora hymenocallidicola on leaves of a fern (Thailand), Melanconium elaeidicola from Elaeis guineensis (Indonesia), Hormonema viticola from Vitis vinifera (Canary Islands), Chlorophyllum pseudoglobossum from a grassland (India), Triadelphia disseminata from an immunocompromised patient (Saudi Arabia), Colletotrichum abscissum from Citrus (Brazil), Polyschema sclerotigenum and Phialemonium limoniforme from human patients (USA), Cadophora vitícola from Vitis vinifera (Spain), Entoloma flavovelutinum and Bolbitius aurantiorugosus from soil (Vietnam), Rhizopogon granuloflavus from soil (Cape Verde Islands), Tulasnella eremophila from Euphorbia officinarum subsp. echinus (Morocco), Verrucostoma martinicensis from Danaea elliptica (French West Indies), Metschnikowia colchici from Colchicum autumnale (Bulgaria), Thelebolus microcarpus from soil (Argentina) and Ceratocystis adelpha from Theobroma cacao (Ecuador). …”
Publicado 2015
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19732por Mašán, Peter“…(based on specimens from Slovakia), Kleemannia dolichochaeta sp. n. (from Spain) and Kleemannia miranda sp. n. (from U.S.A.). …”
Publicado 2017
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19733por Feig, Denice S, Donovan, Lois E, Corcoy, Rosa, Murphy, Kellie E, Amiel, Stephanie A, Hunt, Katharine F, Asztalos, Elizabeth, Barrett, Jon F R, Sanchez, J Johanna, de Leiva, Alberto, Hod, Moshe, Jovanovic, Lois, Keely, Erin, McManus, Ruth, Hutton, Eileen K, Meek, Claire L, Stewart, Zoe A, Wysocki, Tim, O'Brien, Robert, Ruedy, Katrina, Kollman, Craig, Tomlinson, George, Murphy, Helen R“…Participants were pregnant (≤13 weeks and 6 days' gestation) or planning pregnancy from 31 hospitals in Canada, England, Scotland, Spain, Italy, Ireland, and the USA. We ran two trials in parallel for pregnant participants and for participants planning pregnancy. …”
Publicado 2017
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19734por Boix, Francisco, Llorente, Santiago, Eguía, Jorge, Gonzalez-Martinez, Gema, Alfaro, Rafael, Galián, Jose A, Campillo, Jose A, Moya-Quiles, María Rosa, Minguela, Alfredo, Pons, Jose A, Muro, Manuel“…Patients were assessed in our Department of Immunology at the Clinical University ‘Hospital Virgen de la Arrixaca-IMIB’ in Murcia, Spain for one year following transplantation. FACS Canto II flow cytometer was employed to quantify the intracellular production of IL-17, IFNγ and IL-10 cytokines on stimulated CD4(+)CD69(+) and CD8(+)CD69(+) T cells and BD FACS DIVA v.6 software was used to analysed the data. …”
Publicado 2018
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19735por Puig-Navarro, Olga, De la Serna, Elena, Tor, Jordina, Sintes, Anna, Sugranyes, Gisela, Redondo, Marina, Pardo, Marta, Dolz, Montse, Baeza, Inmaculada“…METHODS: Sample: 68 HRS subjects (15.3 ± 1.7 years, 66% females) and 42 HC subjects (15.5 ± 1.5 years, 66% females) from a prospective longitudinal study including help-seeking subjects who met HRS criteria (Child and Adolescent Psychiatry and Psychology departments of Hospital Clínic and Sant Joan de Déu, Barcelona, Spain). Inclusion criteria: age 10–17 years, meeting criteria for 1) attenuated positive or negative symptoms in the previous 12-months, 2) brief intermittent psychotic symptoms, 3) first or second degree relative with schizophrenia or schizotypical disorder plus impairment of functioning. …”
Publicado 2018
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19736por Shenfield, F., de Mouzon, J., Scaravelli, G., Kupka, M., Ferraretti, A.P., Prados, F.J., Goossens, V.“…Furthermore, the data related to use of OoC were not included for two major players in the field, Italy and Spain, where numbers were conflated for medical and non-medical reasons. …”
Publicado 2017
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19737por Alegría, Margarita, Falgas-Bague, Irene, Collazos, Francisco, Carmona Camacho, Rodrigo, Lapatin Markle, Sheri, Wang, Ye, Baca-García, Enrique, Lê Cook, Benjamin, Chavez, Ligia M., Fortuna, Lisa, Herrera, Lizbeth, Qureshi, Adil, Ramos, Zorangeli, González, Claudia, Aroca, Paloma, Albarracín García, Lucía, Cellerino, Lucía, Villar, Ana, Ali, Naomi, Mueser, Kim T., Shrout, Patrick E.“…DESIGN, SETTING, AND PARTICIPANTS: This effectiveness randomized clinical trial was conducted from September 2, 2014, to February 2, 2017, in 17 clinics or emergency departments and 24 community sites in Boston, Massachusetts, as well as in Madrid and Barcelona, Spain. Equal randomization (1:1) in 2-person blocks was used, assigning participants to either the IIDEA treatment group (n = 172) or the enhanced usual care control group (n = 169). …”
Publicado 2019
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19738por Lopez-Morinigo, Javier-David, Escribano-Martínez, Adela Sánchez, Ruiz-Ruano, Verónica González, Mata-Iturralde, Laura, Sánchez-Alonso, Sergio, Muñoz-Lorenzo, Laura, Baca-García, Enrique, David, Anthony“…Sample: Participants are recruited from the outpatient clinic of Hospital Universitario Fundación Jiménez Díaz (Madrid, Spain) over June-December 2019. Inclusion criteria: i) age: 18–64 years, both inclusive, at the study inception; ii) diagnosis: SSD based on the Mini International Neuropsychiatric Interview (Sheehan et al., 1998) and iii) IQ>70 according to the Wechsler Adults Intelligence Scale-IV (Wechsler, 1981). …”
Publicado 2020
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19739“…METHODS: RemindCare app, is offered as an extra-service to the usual psychiatric care of patients in an Early Psychosis Program (EPP) at the Clinic Hospital of Valencia, Spain (Bonet et al. 2019). No remuneration is offered to any patient or clinician to use the app. …”
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19740por Lane, Jennifer C E, Weaver, James, Kostka, Kristin, Duarte-Salles, Talita, Abrahao, Maria Tereza F, Alghoul, Heba, Alser, Osaid, Alshammari, Thamir M, Biedermann, Patricia, Banda, Juan M, Burn, Edward, Casajust, Paula, Conover, Mitchell M, Culhane, Aedin C, Davydov, Alexander, DuVall, Scott L, Dymshyts, Dmitry, Fernandez-Bertolin, Sergio, Fišter, Kristina, Hardin, Jill, Hester, Laura, Hripcsak, George, Kaas-Hansen, Benjamin Skov, Kent, Seamus, Khosla, Sajan, Kolovos, Spyros, Lambert, Christophe G, van der Lei, Johan, Lynch, Kristine E, Makadia, Rupa, Margulis, Andrea V, Matheny, Michael E, Mehta, Paras, Morales, Daniel R, Morgan-Stewart, Henry, Mosseveld, Mees, Newby, Danielle, Nyberg, Fredrik, Ostropolets, Anna, Park, Rae Woong, Prats-Uribe, Albert, Rao, Gowtham A, Reich, Christian, Reps, Jenna, Rijnbeek, Peter, Sathappan, Selva Muthu Kumaran, Schuemie, Martijn, Seager, Sarah, Sena, Anthony G, Shoaibi, Azza, Spotnitz, Matthew, Suchard, Marc A, Torre, Carmen O, Vizcaya, David, Wen, Haini, de Wilde, Marcel, Xie, Junqing, You, Seng Chan, Zhang, Lin, Zhuk, Oleg, Ryan, Patrick, Prieto-Alhambra, Daniel“…Data comprised 14 sources of claims data or electronic medical records from Germany, Japan, the Netherlands, Spain, the UK, and the USA. Propensity score stratification and calibration using negative control outcomes were used to address confounding. …”
Publicado 2020
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