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  1. 2021
    “…Most of the Gd deposits revealed a characteristic spheroid “sea urchin-like” morphology, rich in phosphorus, and were localized in the basal lamina of microvessels, in the perivascular Virchow-Robin space, and in the interstitium. …”
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    Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum: Differences Between Gd Chelates, Presence in the Virchow-Robin Space, Association With Lipofuscin, and Hypotheses About Distribution Pathway
  2. 2022
    “…In conclusion, protamine-induced spheroid aggregation of HLSC triggers a spontaneous differentiation to an endocrine phenotype. …”
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    Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice
  3. 2023
    “…T-DM1 induced ROR1 cells showed high spheroid and tumor forming efficiency in vitro and in an animal model exhibiting shorter tumor-free time. …”
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    Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1
  4. 2024
    “…RESULTS: We first found that IL-1β promotes glioma spheroid formation and is associated with elevated CEBPD expression. …”
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    CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation
  5. 2025
    “…In a lung orthotopic model bronchial carcinoid, cell line derived spheroids, and patient tumor derived 3rd generation spheroids when supported by a stroma, showed robust tumor formation. …”
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    Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane
  6. 2026
    “…Conversely, overexpression of ZIC2 in BPH1 cells caused spheroid formation confirming the oncogenic function of ZIC2. …”
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    Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells
  7. 2027
    “…These results demonstrated that ALDOA-mediated spheroid formation is independent of its enzymatic activity. …”
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    Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness
  8. 2028
    “…There were 2.34 ± 4.77 metastatic lymph nodes for spheroid tumors and 3.21 ± 5.82 for ellipsoid tumors when the cutoff point was 2. …”
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    Growth pattern can be used as a new characteristic to predict malignancy in breast cancer
  9. 2029
    “…Gli1 inhibitor GANT61 significantly decreased the expression of CD44 and LSD1, and spheroid formation ability of the MKN28 cells. CONCLUSIONS: In conclusion, Gli1 may be a poor prognostic indicator and a potential cancer stemness-related protein in GA.…”
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    Gli1 regulates stemness characteristics in gastric adenocarcinoma
  10. 2030
    “…Similarly, amiodarone, an mTOR-independent autophagy enhancer, reduced CD133(+) cell viability and tumor spheroid formation in vitro and exhibited anti-tumor activity in vivo. …”
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    Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death
  11. 2031
    “…MET inhibited Ishikawa cell spheroid formation only in the absence of E2 treatment. …”
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    Metformin regulation of progesterone receptor isoform-B expression in human endometrial cancer cells is glucose-dependent
  12. 2032
    “…Monotherapy using seeMet 12 resulted in impaired cellular migration/proliferation and reduced tumor spheroid growth. Moreover, seeMet 12 was able to potentiate therapeutic effects in vitro for both sorafenib and radiotherapy treatments. …”
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    The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
  13. 2033
    “…We observed that lower let‐7 levels were associated with the epithelial state and a lower epithelial mesenchymal transition (EMT) score, more efficient spheroid and tumor formation, and increased sensitivity to platinum‐based chemotherapy. …”
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    Epithelial/mesenchymal heterogeneity of high‐grade serous ovarian carcinoma samples correlates with miRNA let‐7 levels and predicts tumor growth and metastasis
  14. 2034
    “…Overall, we describe a novel 3D spheroid co-culture system comprising key components of the DLBCL TME with the potential to serve as a testbed for novel therapeutics, targeting key cellular constituents of the TME, such as CAF and/or TAM.…”
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    Developing a 3D B Cell Lymphoma Culture System to Model Antibody Therapy
  15. 2035
    “…In the direct model, LAY-FOMM 40 and PLA showed less impact on viability in the resazurin-based toxicity assay than in the indirect model. Spheroid microtissues showed a reduction of cell activity of GF and PDLF with LAY-FOMM 40 and 60. …”
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    The impact of 3D-printed LAY-FOMM 40 and LAY-FOMM 60 on L929 cells and human oral fibroblasts
  16. 2036
    “…Cellular immunofluorescence was used to identify CTCs and spheroids. The cutoff value of CTC spheroid was calculated using X-tile software. …”
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    3D Culture of Circulating Tumor Cells for Evaluating Early Recurrence and Metastasis in Patients with Hepatocellular Carcinoma
  17. 2037
    “…Spheroid formation was then monitored over a two-week period. …”
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    Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel Formation
  18. 2038
    “…Altogether, these findings suggest that the regulation of the RhoA/ROCK1 signaling pathway is required for CAFs to serve as cellular vehicles in order for EC cells to migrate and form spheroids in a 3D environment.…”
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    Cancer-associated fibroblasts as cellular vehicles in endometrial cancer cell migration
  19. 2039
    “…Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation and bone regeneration capacity of mesenchymal stromal cells (MSC). …”
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    Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs
  20. 2040
    “…Rab27B knockdown cells exhibited decreased expansion as spheroid cultures, transformed growth, and invasion when compared to non-target shRNA control cells. …”
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    4198 Investigating the Role of Rab27B in Non-Small Cell Lung Cancer Tumor Initiating Cells
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