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  1. 2041
    “…To investigate the effects of TBBPA on uterine fibrosis, we developed a 3D human uterine leiomyoma (ht‐UtLM) spheroid culture model. Cell proliferation was evaluated in 3D ht‐UtLM spheroids following TBBPA (10(−6)–200 µM) administration at 48 h. …”
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    Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling
  2. 2042
    “…CUDC-907 potently inhibits NB growth and 3D spheroid tumor growth by inhibiting PI3K, HDAC, and MYCN. …”
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    Dual Targeting of PI3K and HDAC by CUDC-907 Inhibits Pediatric Neuroblastoma Growth
  3. 2043
    “…Methods: The spheroids of NSCLC adenocarcinoma H1975 cells were enriched in a serum-free media. …”
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    The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres
  4. 2044
    “…Wound closure and 3D spheroid invasion assays were used to compare cell motility and migration between parental LNCaP cells and LNCaP cells overexpressing of PROL1. …”
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    PROL1 is essential for xenograft tumor development in mice injected with the human prostate cancer cell-line, LNCaP, and modulates cell migration and invasion
  5. 2045
    por Wang, Yazhu, Wang, Huihan, Wang, Xiaobin
    Publicado 2022
    “…Three-dimensional (3D) spheroid and mouse models were built to verify the effect of the combination treatment. …”
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    Palbociclib regulates the expression of dihydrofolate reductase and the cell cycle to inhibit t (11;14) multiple myeloma
  6. 2046
    “…RESULTS: Knockdown of LOXL2 decreased spheroid formation, migration and invasion (P<0.05), also induced apoptosis (P<0.05) and cell cycle arrest (P<0.05) in CD133(+)HepG2 and CD133(+)Hep3B cells. …”
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    Inhibitory effects of LOXL2 knockdown on cellular functions of liver cancer stem cells
  7. 2047
    “…Treatment with chemerin (huChem-157) significantly reduced OVCAR-3 cell numbers (by 40.8% on day 6) and decreased the colony and spheroid growth of these cells by half. The spheroid size of SK-OV-3 ovarian cancer cells was also significantly reduced upon treatment. …”
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    Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response
  8. 2048
    “…R HSC-3 cells also highly expressed CD44, a cancer stem cell marker, and exhibited enhanced cell invasion and spheroid formation abilities. Furthermore, the stem cell-related factor SRY-box transcription factor 9 (SOX9) was identified as increased in R HSC-3 cells by microarray analysis. …”
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    ABCG2, CD44 and SOX9 are increased with the acquisition of drug resistance and involved in cancer stem cell activities in head and neck squamous cell carcinoma cells
  9. 2049
    “…Chronic hypoxia for 72 h resulted in CSC phenotypes, including elevation of krupple-like factor 4 (KLF4) and octamer-binding transcription factor 4 (OCT4), and an increase in cancer migration and spheroid growth with concomitant hypoxia-inducible factor 2α (HIF-2α) accumulation. …”
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    Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition
  10. 2050
    “…Additionally, both LepR(+) and LepR(−) PDL cells demonstrated spheroid-forming capacity, which is an indicator of self-renewal. …”
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    Subset of the periodontal ligament expressed leptin receptor contributes to part of hard tissue-forming cells
  11. 2051
    “…The present study aims to evaluate the cytotoxic effect, the morphological changes in tumor spheroids, the effect on the cell viability, and the cell-specific growth rate following calcium electroporation (CaEP) in uveal melanoma (UM) 2D monolayer cell cultures as well as in 3D tumor spheroid models. …”
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    Calcium Electroporation Reduces Viability and Proliferation Capacity of Four Uveal Melanoma Cell Lines in 2D and 3D Cultures
  12. 2052
    “…The in vitro anticancer activity of three LFCs was extensively studied in both 2D monolayer and 3D spheroid culture models of a prostate cancer cell line, PC3. …”
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    Physicochemical and Biopharmaceutical Controllability of New Self-Assembled Fatty Acid Conjugated Leuprolide for the Enhanced Anticancer Activity
  13. 2053
    “…Co-spheroids were generated in a well-defined and reproducible manner in a high-throughput process. …”
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    Three-Dimensional Breast Cancer Model to Investigate CCL5/CCR1 Expression Mediated by Direct Contact between Breast Cancer Cells and Adipose-Derived Stromal Cells or Adipocytes
  14. 2054
    “…These two agents also significantly suppressed cell growth in spheroid cultures and induced apoptosis in MET overexpressing AsPC-1 cells. …”
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    Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
  15. 2055
    “…Co-administration of the MCT4 inhibitor and ICB augmented immune cell infiltration, T-cell function and decreased CRC spheroid viability in a 3D co-culture model of human CRC spheroids with blood leukocytes. …”
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    MCT4 blockade increases the efficacy of immune checkpoint blockade
  16. 2056
    por Zhang, Kexiong, Waxman, David J
    Publicado 2010
    “…METHODS: Single cell cloning and spheroid culture studies were used to identify a population of cancer stem-like cells in the androgen-independent human prostate cancer cell line PC3. …”
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    PC3 prostate tumor-initiating cells with molecular profile FAM65B(high)/MFI2(low)/LEF1(low )increase tumor angiogenesis
  17. 2057
    “…Furthermore we studied the impact galectin-1 has on the metabolic activity of MCF-7 and T-47D cells in a homotypic three-dimensional spheroid cell culture model mimicking a micro tumour environment. …”
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    Binding of galectin-1 to breast cancer cells MCF7 induces apoptosis and inhibition of proliferation in vitro in a 2D- and 3D- cell culture model
  18. 2058
    “…Implanted spheroids and cartilage tissue were co-cultured ex vivo for 12 weeks to allow regeneration processes to form new tissue within the cartilage defect. …”
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    An ex vivo human cartilage repair model to evaluate the potency of a cartilage cell transplant
  19. 2059
    “…We generated lung adenocarcinoma stem-like cells from spheroid culture and induced their transdifferentiation by a two-stage method of knocking down HIF1α expression followed by vitamin Dand suberoylanilide hydroxamic acid (VD3/SAHA) treatment. …”
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    Two-stage induced differentiation of OCT4(+)/Nanog(+) stem-like cells in lung adenocarcinoma
  20. 2060
    “…RESULTS: Anacardic acid induced an anticancer effect in pancreatic cancer cell lines in a dose dependent manner, and increased the cytotoxicity of 5-Fluorouracil or Gemcitabine in MTT cell viability assays. In spheroid formation assays, spheroids formed were smaller in size and in number upon Anacardic acid treatment compared to control. …”
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    Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway
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