“…In this paper, we derive a mathematical model for the infiltration of an in vitro tumour spheroid by macrophages that have been engineered to release an oncolytic adenovirus under hypoxic conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Human enteroids—epithelial spheroids derived from primary gastrointestinal tissue—are a promising model to study pathogen-epithelial interactions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Immunohistochemical analyses indicated good hepatocyte survival under the dynamic culture system with effective hepatocyte spheroid formation in the patterned microfluidic chip vs. static culture conditions and tissue culture plate (TCP). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we used a tumor organoid model, consisting of hepatic stellate cells (HSCs) embedded in collagen type 1 (Col1) and colorectal cancer cell (HCT-116) spheroids, to determine the relationship between the ECM architecture, cancer cell malignancy, and chemoresistance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To qualitatively demonstrate that the system can reduce shadow artefacts while providing a more isotropic resolution, a multi-cellular spheroid approximately 100 µm in diameter was imaged.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mature rod-shaped cardiomyocytes contain thousands of end-to-end contacted spheroid mitochondria. The movement of mitochondria in these cells is limited, which hinders the impetus for research into mitochondrial dynamics in adult cardiomyocytes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The multicellular tumor spheroid, organoids, scaffolds, microfluidic devices and 3D bioprinting currently being utilized in NSCLC hypoxia studies are reviewed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, RBM24 could suppress sphere formation in a multicellular tumor spheroid model of liver cancer cells. In conclusion, it is hypothesized that RBM24 is a tumor suppressor of liver cancer cells, which could be a potential novel therapeutic target for treatment of patients with liver cancer.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Apart from stationary rotation, elongated-spheroid-like liquid marbles were found, for the first time, to exhibit pulsed rotation on water surfaces characterized by a threshold speed of rotation, which increased with the weight of the liquid marble while the frequency of pulses proved to decrease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These “microphysiological” systems—in vitro human cell culture systems designed to replicate in vivo physiology—employ varying levels of biomimicry and engineering control. Spheroid-based organoids, 3D cell culture systems, and microfluidic devices or a combination of these have the potential to replicate AD pathophysiology and pathogenesis in vitro and thus serve as both tools for testing therapeutics and models for experimental manipulation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through dual targeting from magnetic guidance and M1 macrophages, the microrobots were able to target and kill cancer cells in a 3D tumor spheroid culture assay. These findings demonstrate a way to improve the tumor-targeting and antitumor abilities of microrobots through the combined use of magnetic control, macrophages, and pH-responsive drug release.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through integrating 3D bioprinting and NB spheroid technologies, in article number 2200244, Kelly C. …”
Enlace del recurso
Enlace del recurso

“…Not only can these CNPs be specifically taken up by cells, but they also stimulate cellular processes such as cell invasion from 3D spheroid models. This new class of CNPs, which have sizes similar to those of proteinaceous ligands, hold immense potential for their surface functionalization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…KO cell lines for both PLDs were generated using CRISPR/CAS9 technology and assayed for exosome secretion, spheroid formation, migration, invasion and expression of molecules involved in epithelial-mesenchymal transition (EMT) and intracellular signaling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this review, we will summarize our current understanding of the cell cycle processes in the spheroid model bacterium S. aureus, with a focus on recent advances in the understanding of how these processes are regulated.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The effector phenotype of co-cultured CD8+ T cells exemplified by expression of activation markers and release of effector molecules was rather enhanced by PDAC macrophage spheroids, particularly with M1-like macrophages compared to mono-culture spheroids. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additionally, pelitinib was found to inhibit multicellular cancer spheroid invasion and metalloprotease activities in Huh7 cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CD13(+)/CD166(−) cells showed high ALDH activity, spheroid forming ability and resistance to 5-fluorouracil. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Proliferation, survival, and spheroid formation were assessed in response to Mcl-1 and Her2 inhibition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso