“…DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and Malme3M(R) cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The model is specified to in-vitro data, facilitating biophysically realistic simulations of tumour spheroid growth into a dense collagen hydrogel. We use the model to first confirm that passive mechanical remodelling of collagen fibres at the tumour boundary is driven by solid stress, and not fluid pressure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…At low, non-cytotoxic concentrations, BP compounds significantly increased spheroid formation in CSC221, DLD1, Caco2, and HT29 cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In contrast to the preferred two‐dimensional cell‐based screening, three‐dimensional (3D) systems have more in vivo relevance as well as ability to perform as a predictive tool for the success or failure of a drug screening campaign. 3D cell culture has shown an adaptive response to the recent advancements in microfluidic technologies which has allowed better control over spheroid sizes and subsequent drug screening studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The smaller volume of the central protoplast is accompanied by decreased movement rates of tubules, cisternae, and spheroid organelles, but this reduced movement is not readily reversed by the increase in volume that accompanies deplasmolysis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein, we describe types of 3D culture that are used to model the esophagus, including organotypic, organoid, and spheroid culture systems. We discuss the development and optimization of various esophageal 3D culture models; highlight the applications, strengths, and limitations of each method; and summarize how these models have been used to evaluate the esophagus under homeostatic conditions as well as under the duress of inflammation and precancerous/cancerous conditions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cellular apoptosis was quantified in multiple environments ranging from 2D flat and 3D spheroid cell culture systems to in vivo murine mammary tumor xenografts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mouse organoid drug screening identifies that itraconazole generates spheroid collapse and loss of dormancy. Human CRC cell dormancy and tumor growth can also be perturbed by itraconazole, which is found to inhibit Wnt signaling through noncanonical hedgehog signaling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Materials and Methods: Oral cancer stem cells were isolated from HPV+ve/HPV–ve oral cancer cell lines by FACS and stemness markers. MTT, spheroid assay and qRT-PCR were employed to examine the effects of curcumin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PDL1-Dox demonstrates significant cell killing, disruption of tumor spheroid and induction of apoptosis in a breast cancer cell line. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we developed a fiber-embedded polydimethylsiloxane (PDMS) chip to culture hepatocytes. Hepatocyte spheroids formed in this device were subjected to different flow rates, of which a flow rate of 50 μL/min provided the optimal microenvironment for spheroid formation, maintained significantly higher rates of albumin and urea synthesis, yielded higher CYP3A1 (cytochrome P450 3A1) and CYP2C11 (cytochrome P450 2C11) enzyme activities for metabolism, and demonstrated higher expression levels of liver-specific genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Insights into their behavior in biological systems were gathered by means of amino‐acid interaction studies, cytotoxicity tests in 3D spheroid models, laser ablation, cellular accumulation measurements, as well as cell cycle experiments.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The M2-like TAMs are also important players in the metastasis of ovarian cancer cells in the peritoneum through their assistance in spheroid formation and attachment of cancer cells to the metastatic area—the omentum. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Also, the instability of droplets during the spheroid formation remains an unsolved ordeal. In this study, we designed a microfluidic-based hanging-drop culture system with the design of taper-tube that can increase the stability of droplets while enhancing the rate of liquid exchange. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It was found that lignin exists independently of silica in the secondary cell walls of parenchymal and sclereid cells and that silica exists independently of lignin in the spheroid phytoliths that surround the sclereid cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…NHI-Glc-2 inhibits LDH-A enzyme activity, PANC-1 cell growth and disrupts spheroid integrity, with an overall effect that is more pronounced when combined with gemcitabine.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, it suppressed CSC-related gene expression and spheroid formation in vitro, indicating depletion of CSCs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thorough analyses were performed around critical parameters, such as the plasmonic metal—Silver, Aluminium or Gold—using Rakic model, the tip geometry—sphere, spheroid, ellipsoid, nano-cone, nano-shell, rod, cavity—and the geometry of the plasmonic array: cross-talk in multiple nanostructures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our qPCR analysis has revealed that, during the formation of ribosome induced cancer cell spheroids, the expression of the cancer cell associated markers and cell cycle/proliferation markers were altered at different time point. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we provide an overview of different submerged, organotypic 3D and spheroid cell culture models of nasal epithelial cells, which were used to study asthma and allergy with a special focus on virus infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso