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Mostrando 261 - 280 Resultados de 6,033 Para Buscar '"Spheroid', tiempo de consulta: 0.15s Limitar resultados
  1. 261
    “…OBJECTIVE: The spheroid model provides a physiological platform to study cancer cell biology and drug sensitivity. …”
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    Rapid spheroid assays in a 3-dimensional cell culture chip
  2. 262
    “…MIA PaCa-2 spheroids polarized infiltrating monocytes to M2-like macrophages with high CD206 and CD14 expression, whereas monocytes polarized by MCF-7 spheroids displayed an M1-like phenotype. …”
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    Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models
  3. 263
    “…The distributions of the resulting metabolic rates of the spheroids were computed by modeling oxygen diffusion and reaction. …”
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    Scaling of joint mass and metabolism fluctuations in in silico cell-laden spheroids
  4. 264
    “…Recently, 3D cell culture methods, such as stem cell–based spheroids and organoids, have demonstrated advantages by incorporating tissue-mimetic 3D cell-cell interactions. …”
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    Hybrid SMART spheroids to enhance stem cell therapy for CNS injuries
  5. 265
    “…Three-dimensional (3D) spheroid cultures comprising MSCs mimic the biological microenvironment more accurately than two-dimensional cultures; however, it remains unclear whether DFAT cells in 3D spheroids possess high osteogenerative ability. …”
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    Three-dimensional spheroids of dedifferentiated fat cells enhance bone regeneration
  6. 266
    “…The method was applied to the evaluation of a tumor spheroid. The time-course viability alteration and anti-cancer drug response of the spheroid were visualized qualitatively and analyzed quantitatively. …”
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    Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation
  7. 267
    “…Next, we compared the efficacy of a model anticancer peptide (ACP) in cell monolayers and spheroids. Overall, the results demonstrated spheroids to be less sensitive to treatment than cell monolayers, revealing the need for more robust models in drug development.…”
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    Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide
  8. 268
    “…Here, we present the first human in vitro model of non-penetrating TBI employing three-dimensional spheroidal cultures. We used a custom-built device to traumatize these spheroids in a quantifiable, repeatable and biofidelic manner, and correlated the heterogeneous mechanical strain field with the injury phenotype. …”
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    Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes
  9. 269
    “…We established monocellular spheroids from two human (GC) cell lines, HGT-1 and AGS, and bicellular spheroids from these cells mixed with cancer-associated fibroblasts. …”
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    Gastric cancer cell death analyzed by live cell imaging of spheroids
  10. 270
    “…Moreover, the µg-environment induces in vitro 3D tumor models (multicellular spheroids and organoids) with a high potential for preclinical drug targeting, cancer drug development, and studying the processes of cancer progression and metastasis on a molecular level. …”
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    The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model
  11. 271
    “…Crucial in the pathogenesis of neurodegenerative diseases is the process of neuroinflammation that is often linked to the pro-inflammatory cytokines Tumor necrosis factor alpha (TNFα) and Interleukin-1beta (IL-1β). Human cortical spheroids (hCSs) constitute a valuable tool to study the molecular mechanisms underlying neurological diseases in a complex three-dimensional context. …”
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    Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids
  12. 272
    “…Herein, we describe a protocol for the preparation and analysis of primary isolated rat hepatocytes in a 3D cell culture format described as spheroids. The hepatocyte cells spontaneously self‐aggregate into spheroids without the need for synthetic extracellular matrices or hydrogels. …”
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    Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid‐Overlay Technique
  13. 273
    “…In this study, H9C2 cardiac-derived myoblasts were encapsulated as individual cells and as cell spheroids within stiffness gradient gelatin methacryloyl (GelMA) hydrogels to investigate individual and collective cardiac cell mechanosensation in 3D. …”
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    Mechanosensation mediates volume adaptation of cardiac cells and spheroids in 3D
  14. 274
    “…Tissue spheroids represent an innovative solution for tissue engineering and regenerative medicine. …”
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    Research Dynamics of Tissue Spheroids as Building Blocks: A Scientometric Analysis
  15. 275
    “…Veno-occlusive disease was induced by azathioprine exposure, leading to impeded perfusion of the vascularized spheroid. The platform holds the potential to replace animals with an in vitro alternative for routine grafting of spheroids, organoids, or (patient-derived) explants. …”
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    In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
  16. 276
    “…Monolayered eMSCs expressed VEGFR1, while spheroid eMSCs expressed both VEGFR1 and VEGFR2 receptors. …”
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    Paracrine and Autocrine Effects of VEGF Are Enhanced in Human eMSC Spheroids
  17. 277
    “…Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction. …”
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    PLD3 affects axonal spheroids and network defects in Alzheimer’s disease
  18. 278
    “…In this work, three kinds of tungsten powders with different particle sizes were spheroidized by radio-frequency (RF) inductively coupled plasma spheroidization. …”
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    Research on Spheroidization of Tungsten Powder from Three Different Raw Materials
  19. 279
    “…In vitro tumor spheroids have proven to be useful 3D tumor culture models for drug testing, and determining the molecular mechanism of tumor progression and cellular interactions. …”
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    Assessing Polysaccharides/Aloe Vera–Based Hydrogels for Tumor Spheroid Formation
  20. 280
    “…Focusing on oxygen variability to develop our framework, we reveal key biological mechanisms governing tumour spheroid growth. Growing spheroids in time-dependent conditions, we identify and quantify novel biological adaptation mechanisms, including unexpected necrotic core removal, and transient reversal of the tumour spheroid growth phases.…”
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    Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability
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