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  1. 2901
    “…To explore the molecular mechanisms underlying the inflammation-mediated induction of intestinal tumorigenesis, the present study investigated the function of tumor necrosis factor (TNF)-α in the malignant transformation of ISCs. NCM460 spheroid (NCM460s) cells with higher expression of stem cell genes, such as Oct4, Nanog, Sox2 and Lgr5, and with a higher ratio of CD133(+), were obtained from NCM460 cells in serum-free medium. …”
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    TNF-α promotes the malignant transformation of intestinal stem cells through the NF-κB and Wnt/β-catenin signaling pathways
  2. 2902
    “…Knockdown of NGFR markedly reduced the size and number of spheroid formation of melanoma cells, which can be rescued by ectopically expressed NGFR. …”
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    Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis
  3. 2903
    “…Overexpression of YY1 increased the expression of stemness markers, elevated CD44(+)CD24(−) cell sub-population, and enhanced the capacity of cell spheroid formation and tumor-initiation. In contrast, YY1 knockdown exhibited the opposite effects. …”
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    Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity
  4. 2904
    “…Several advances in tissue engineering have allowed more physiologically relevant three-dimensional (3D) in vitro cancer models, such as spheroid cultures, biopolymer scaffolds, and cancer-on-a-chip devices. …”
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    3D bioprinting for reconstituting the cancer microenvironment
  5. 2905
    “…METHODS: Cell viability was analysed by MTT, clonogenic, tumour spheroid, and cancer stem cell sphere assays. Western blot assay was performed to detect the protein expression. …”
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    CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum
  6. 2906
    “…These sugar derivatives are utilized alone and as mixture, resulting in spherical, spheroid, trigonal, polygonic, and star-like morphologies. …”
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    On the Effect of Modified Carbohydrates on the Size and Shape of Gold and Silver Nanostructures
  7. 2907
    “…Furthermore, we identified the possibility of vitrification of size-controlled 3-D spheroids for cryopreservation of organoid with high survivability. …”
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    Vitrification for cryopreservation of 2D and 3D stem cells culture using high concentration of cryoprotective agents
  8. 2908
    “…Similarly, both isolated human CD24(−/low) SKOV3 stem-like cells and spheroid OVCAR3 cells expressed lower CD47 levels. …”
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    Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells
  9. 2909
    “…PMTPV elevated the accumulation and cytotoxicity of DXR in the spheroids. Similar results were observed by knockdown of CLDN1. …”
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    Increase in Toxicity of Anticancer Drugs by PMTPV, a Claudin-1-Binding Peptide, Mediated via Down-Regulation of Claudin-1 in Human Lung Adenocarcinoma A549 Cells
  10. 2910
    “…The effects of CD109 expression were examined on migration, cell proliferation, spheroid formation and soft-agar colony-formation assay. …”
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    CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma
  11. 2911
    “…Migration and invasion of TYS cells into collagen gels from the spheroids was stimulated by CM from both fibroblast cell lines, compared to the negative control. …”
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    Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt?
  12. 2912
    “…The role of ZIC2 in LAC CSC were analyzed by evaluation of CSC-related markers expression and spheroid formation in vitro. Cisplatin and paclitaxel resistance capacities were evaluated by CCK8 assay, colony formation assay, and flow cytometry analysis. …”
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    ZIC2 promotes cancer stem cell traits via up-regulating OCT4 expression in lung adenocarcinoma cells
  13. 2913
    “…Additionally, this is an optimized protocol for the establishment of a 3D system for this cell line, which is normally seen as challenging to spontaneously form spheroids. The addition of patient-derived immune cells to the cancer cells' spheroid allows the study of the crosstalk between both cell types, as well as the assessment of individual therapeutic approaches to intensify the antitumor immune response. …”
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    Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Patient-Derived Immune Cells for Application in the Development of Immunotherapies
  14. 2914
    “…In the present study, we show that ACTL6A drives SCC cell proliferation, spheroid formation, invasion and migration, and that these activities are markedly reduced by ACTL6A knockdown. …”
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    ACTL6A suppresses p21(Cip1) expression to enhance the epidermal squamous cell carcinoma phenotype
  15. 2915
    “…METHODS: The role of GREM1 in breast cancer progression was assessed by measuring cell viability, colony formation, 3D tumour spheroid formation/invasion and xenograft tumour formation. …”
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    Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer
  16. 2916
    “…The present study assessed the effects of BMP-2 on stem cell spheroid morphology, viability and osteogenic differentiation. …”
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    Bone morphogenetic protein 2-enhanced osteogenic differentiation of stem cell spheres by regulation of Runx2 expression
  17. 2917
    “…RESULTS: We produced stable, small, spheroid PVP-coated BiNPs with a crystalline organization. …”
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    Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans
  18. 2918
    “…In addition, N-acetylcysteine reduced ROS production and improved ΔΨm loss and cell death that were caused by apigenin. In a 3D spheroid culture model, ROS-dependent necroptosis was found to be a mechanism involved in the anti-cancer activity of apigenin against malignant mesothelioma cells. …”
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    Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells
  19. 2919
    “…Several spheroids developed 0.1- to 1-mm-long capillary-like tubules connecting other spheroids, thus forming a complex network that underwent remodeling over several months. …”
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    Characterization of ascites-derived aldehyde dehydrogenase–positive ovarian cancer stem cells isolated from Leghorn chickens
  20. 2920
    “…The AAV3B-DE5 variant described herein was undetectable in the original viral library but gained a selective advantage upon in vitro passaging in human hepatocarcinoma spheroid cultures. AAV3B-DE5 contains 24 capsid amino acid substitutions compared with AAV3B, distributed among all five variable regions, with strong selective pressure on VR-IV, VR-V, and VR-VII. …”
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    Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity
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