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  1. 3301
    “…By cytological examination, CTCs were identified in 18/41 CRC cases (43.9%). In cell cultures, spheroid-like structures or tumor-cell clusters were found in 18/33 tested cases (54.5%). …”
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    Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates
  2. 3302
    “…The results showed that MSX1 was significantly upregulated with E(2)- and P(4)-alone treatment, or their combined treatment, and IFNτ further enhanced its expression. The spheroid attachment and PGE2/PGF2α ratio were downregulated by the suppression of MSX1. …”
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    MSX1 Regulates Goat Endometrial Function by Altering the Plasma Membrane Transformation of Endometrial Epithelium Cells during Early Pregnancy
  3. 3303
    “…PURPOSE: The current study aimed to evaluate the synergistic efficacy of lenvatinib and FOLFOX (infusional fluorouracil (FU), folinic acid, and oxaliplatin) in hepatocellular carcinoma (HCC) using patient-derived xenograft (PDX) and PDX-derived organotypic spheroid (XDOTS) models in vivo and in vitro. METHODS: PDX and matched XDOTS models originating from three patients with HCC were established. …”
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    Synergistic Effect of Lenvatinib and Chemotherapy in Hepatocellular Carcinoma Using Preclinical Models
  4. 3304
    “…Myofibroblasts (MFs) are present both within the tumor mass (intratumoral MFs, iMFs) and at the tumor border (peritumoral MFs, pMFs). Using a spheroid-based coculture system, we show that the initial iCCA-pMF contact is growth suppressive to the tumor cells. …”
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    Spatiotemporal regulation of cholangiocarcinoma growth and dissemination by peritumoral myofibroblasts in a Vcam1-dependent manner
  5. 3305
    “…Functional assays will then be carried out to observe differences in cell proliferation, cell migration, and spheroid formation in the genetically edited compared to unedited cell lines. …”
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    20 Discovery of Novel African American Genetic Risk Factors for Breast Cancer by Analyzing Whole Genome Sequencing Data of the Alabama Hereditary Cancer Cohort
  6. 3306
    “…However, the mechanism by which visfatin induces anoikis resistance in ovarian cancer spheroids remains unknown. Here, we aimed to assess wheather visfatin which possess anti-apoptotic properties can induce resistance of anoikis in ovarian cancer spheroids. …”
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    Visfatin induces ovarian cancer resistance to anoikis by regulating mitochondrial activity
  7. 3307
    por Shen, Yan, Ni, Siyi, Li, Si, Lv, Bin
    Publicado 2023
    “…The stemness of CRC cells was detected by spheroid formation assay, and the expression of stemness‐related prognostic genes was verified by qRT‐PCR and Western blot. …”
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    Role of stemness‐related genes TIMP1, PGF, and SNAI1 in the prognosis of colorectal cancer through single‐cell RNA‐seq
  8. 3308
    por Peterziel, Heike, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F, Herter, Sonja, Fiesel, Petra, Berker, Yannick, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C, Reuss, David, Turunen, Laura, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U, Gojo, Johannes, Hutter, Caroline, Øra, Ingrid, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert, Nathrath, Michaela, Sparber-Sauer, Monika, Sehested, Astrid, Kramm, Christof M, Dirksen, Uta, Kallioniemi, Olli, Pfister, Stefan M, van Tilburg, Cornelis M, Jones, David T W, Saarela, Jani, Pietiäinen, Vilja, Jäger, Natalie, Schlesner, Matthias, Kopp-Schneider, Annette, Oppermann, Sina, Milde, Till, Witt, Olaf, Oehme, Ina
    Publicado 2023
    “…DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. …”
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    OTHR-04. DEVELOPMENT OF A FUNCTIONAL PLATFORM FOR REAL-TIME PERSONALIZED DRUG SENSITIVITY PROFILING OF PATIENT-DERIVED 3D FRESH TUMOR TISSUE CULTURES IN THE PEDIATRIC PRECISION ONCOLOGY PROGRAM INFORM
  9. 3309
    “…Cells isolated from Xmm66 spheroids derived from metastatic UM patient material were injected into 2 days-old zebrafish larvae resulting in micro-metastases in the liver and caudal hematopoietic tissue. …”
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    Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
  10. 3310
    “…Forced expression of miR-506 or miR-150 significantly increased the susceptibility of Leptin+ cells to palbociclib treatment by inhibiting colony and tumor spheroid formation, and CD44 expression in Panc-1 and MiaPaCa-2 cells. …”
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    Palbociclib suppresses the cancer stem cell properties and cell proliferation through increased levels of miR-506 or miR-150 in Panc-1 and MiaPaCa-2 cells
  11. 3311
    “…Second, by integrating a pure PEG hydrogel into the PCL mesh, significant swelling is induced, which leads to the formation of a non-adherent biological scaffold with a large curvature that is useful for spheroid formation. In conclusion, we demonstrate the development of a handling platform for hydrogel cell culture scaffolds for easy integration with conventional measurement techniques and miniaturized organs-on-chip systems.…”
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    Technology platform for facile handling of 3D hydrogel cell culture scaffolds
  12. 3312
    “…Our results also demonstrated that this novel biomimetic nanomedicine-based cancer starvation therapy synergistically improved the therapeutic efficiency against breast cancer cells by blocking energy metabolic pathways, which resulted in a significant reduction of cancer cell proliferation, 3D tumor spheroid growth as well as in vivo tumor growth.…”
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    Biomimetic nanovesicle co-delivery system impairs energy metabolism for cancer treatment
  13. 3313
    “…Our morphological image analysis showed that BPA exposure at 0.01, 0.1 and 1 µM decreased the average spheroid size by day 21 (D21) of the neural induction, while no effect on cell viability was detected. …”
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    Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model
  14. 3314
    “…Surgical intervention successfully removed the spheroid mass, leading to the alleviation of symptoms. …”
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    A polo ball in the right atrium, importance of echocardiographic characteristics of intracardiac myxomas: a case report
  15. 3315
    “…Indeed, Fingolimod had little or no effect on 3D spheroid cytotoxicity and was devoid of effect on in vivo tumor progression in Temozolomide-sensitive models. …”
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    Evaluation of Temozolomide and Fingolimod Treatments in Glioblastoma Preclinical Models
  16. 3316
    “…The goal of our current work is to map the progesterone-driven gene expression in CSC cells through transcriptomic profiling of T47D cells grown in spheroid-culture conditions that express exclusively PR-A or PR-B. …”
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    THU570 Isoform Specific Gene Regulation By Progesterone Receptors Drives Expansion Of Breast Cancer Stem Cell Expansion In 3D Cell Culture Models
  17. 3317
    “…The Fe coating on paclitaxel-loaded nanocapsules permitted efficient magnetic enhancement of the cancer spheroid assembly, with 40% reduction of the cross-section area after 24 h, as well as a higher paclitaxel effect. …”
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    Modular Drug-Loaded Nanocapsules with Metal Dome Layers as a Platform for Obtaining Synergistic Therapeutic Biological Activities
  18. 3318
    “…But, under nutrient deprivation or conventional chemotherapy, SAOS2 growth can be favored in spheroids. Importantly, when the simplest heterogeneity state is evaluated, a two-cell line coculture, perturbations that affect the faster growing cell line have only a modest effect on final spheroid size. …”
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    Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
  19. 3319
    por Fricke, Hugo
    Publicado 1925
    “…The following formula holds for the specific capacity of a suspension of spheroids, each of which is composed of a well conducting interior surrounded by a thin membrane of a comparatively high resistance: See PDF for Equation C, specific capacity of suspension; C(o), static capacity of one sq. cm. of membrane; r, r (1) specific resistances respectively of suspension and of suspending liquid; 2 q major axis of spheroid, α constant tabulated in Table I. 3. …”
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    THE ELECTRIC CAPACITY OF SUSPENSIONS WITH SPECIAL REFERENCE TO BLOOD
  20. 3320
    “…Cells were drug exposed as monolayer or multicellular spheroid cultures. Cells residing at differing oxygenation status were isolated from Hoechst 33342-treated spheroids using flow cytometry. …”
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    Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells
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