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  1. 3421
    “…IC(50) values demonstrated higher resistance of 3D spheroids to docetaxel (DTX), doxorubicin (DOX) and erlotinib compared to 2D monolayers of NSCLC-PDX, wild type triple negative breast cancer (MDA-MB-231 WT) and lung adenocarcinoma (HCC-827) cells. …”
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    Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening
  2. 3422
    “…Cells in three‐dimensional culture were suspended and they grew into dense multicellular spheroid (MCS) structures, aggregating with each other. …”
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    Biological features, gene expression profile, and mechanisms of drug resistance of two‐ and three‐dimensional hepatocellular carcinoma cell cultures
  3. 3423
    “…SIMPLE SUMMARY: SOX2, OCT4, and NANOG are enriched in ovarian cancer spheroids and correlate with tumor-initiating cell markers, CD117 and ALDH/CD133. …”
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    Characterization of SOX2, OCT4 and NANOG in Ovarian Cancer Tumor-Initiating Cells
  4. 3424
    “…Affected lambs showed progressive ataxia and stiff gait and subsequent histopathological analysis revealed the widespread presence of axonal spheroid indicating neuronal degeneration. Thus, the observed clinical phenotype could be explained by a novel form of NAD. …”
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    Compound heterozygous PLA2G6 loss-of-function variants in Swaledale sheep with neuroaxonal dystrophy
  5. 3425
    “…KEY MESSAGES: In vivo maintenance of episomal KSHV can be mimicked in 3D spheroid cultures; 3D maintenance of KSHV is associated with an increased de novo infection frequency. …”
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    3D culture conditions support Kaposi’s sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells
  6. 3426
    por Kouroupis, Dimitrios, Correa, Diego
    Publicado 2021
    “…In that context, MSC 3D spheroids have shown enhanced “medicinal signaling” activities and increased homing and survival capacities upon transplantation in vivo. …”
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    Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications
  7. 3427
    “…The lead compound 5h was also tested in a tumor spheroid assay using the HL60 cell line and exhibited greater photocytotoxicity in this more resistant model (EC(50) = 60 nM and PI > 1200 with 625 nm light) despite a lower dark cytotoxicity. …”
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    Bis[pyrrolyl Ru(ii)] triads: a new class of photosensitizers for metal–organic photodynamic therapy
  8. 3428
    por Liu, Yuhong, Xu, Gang, Li, Lin
    Publicado 2021
    “…In addition, GATA3-AS1 knockdown suppressed the stemness of PANC-1 and AsPC-1 cells by decreasing the spheroid formation ability. A tumor xenograft in vivo assay demonstrated that GATA3-AS1 knockdown inhibited tumorigenicity of AsPC-1 cells. …”
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    LncRNA GATA3-AS1-miR-30b-5p-Tex10 axis modulates tumorigenesis in pancreatic cancer
  9. 3429
    “…The downregulation of KDM2B retarded cell proliferation, induced DNA damage, reduced spheroid formation, and decreased CRC stem cell markers: CD44, CD133, and ALDH-1. …”
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    The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway
  10. 3430
    “…Inhibition of ATR also suppressed clonogenicity and spheroid growth of ovarian cancer cells. CONCLUSION: Our results support the ATR and p-ATR pathway as a prognostic biomarker, and targeting the ATR machinery is an emerging therapeutic approach in the treatment of ovarian cancer.…”
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    ATR and p-ATR are emerging prognostic biomarkers and DNA damage response targets in ovarian cancer
  11. 3431
    “…Additionally, the effects of pharmacological inhibition of trametinib and XMD8-92 on nuclear localization of ERK1/2 and ERK5, cell migration, proliferation, and spheroid formation were evaluated. Novel compounds that target the MEK1/2 and MEK5 pathways were used in combination with the AKT inhibitor ipatasertib to understand cell-specific responses to kinase inhibition. …”
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    Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer
  12. 3432
    “…AChE inhibitors identified from the primary screening were further tested in monolayer or spheroid formed by SH-SY5Y and neural stem cell models. …”
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    Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition
  13. 3433
    “…Results from colony formation, immigration and invasion assays support the anticancer efficacy of Tiliroside and its low-toxic property while treating liver normal cell THLE-3. 3D spheroid formation and CD133 expression level also displays its anti-stemness effect. …”
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    Tiliroside as a CAXII inhibitor suppresses liver cancer development and modulates E2Fs/Caspase-3 axis
  14. 3434
    “…We show that ARRB1 is crucial for spheroid formation and tumorigenic potential. Furthermore, we measured mitochondrial respiration, glucose uptake, glycolytic rate, mitochondrial/glycolytic ATP production and fuel oxidation in previously established ARRB1 knock out (KO) cells and corresponding controls. …”
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    ARRB1 Regulates Metabolic Reprogramming to Promote Glycolysis in Stem Cell-Like Bladder Cancer Cells
  15. 3435
    “…Moreover, in a neutrophil-tumor spheroid co-culture system, neutrophils migrated with increased directionality towards spheroids generated from TNBC cells compared to ER+ cells. …”
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    Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands
  16. 3436
    “…In addition, SOX9 silencing in the HCT116 cell line was performed using specific small interfering RNAs, while downregulation efficiency was verified by reverse transcription-quantitative PCR and immunofluorescence. Spheroid-formation assay was carried out using ultra-low attachment plates. …”
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    SOX9 is associated with advanced T-stages of clinical stage II colon cancer in young Mexican patients
  17. 3437
    “…Fluorescent reporter-based analysis of autophagy flux, spheroid and side population (SP) culture, and qPCR were done. …”
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    PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells
  18. 3438
    “…Anti-proliferative and apoptotic functions of SPNs were evaluated in spheroids and non-spheroids with MTT, DNA fragmentation, PI and PI/AnnexinV assays. …”
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    PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets
  19. 3439
    “…We also provide evidence of a direct correlation between LAMC1 expression levels and H-1PV oncolytic activity in 59 cancer cell lines and in 3D organotypic spheroid cultures with different sensitivities to H-1PV infection. …”
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    Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
  20. 3440
    “…The same trend was seen in luminal muscle-invasive bladder cancer model (TSU-Pr1/B1/B2) and the non-muscle-invasive basal 5637 bladder cancer cell line. Three-dimensional spheroid cultures of the bladder cancer cell lines were less sensitive to the PAM treatment compared to their two-dimensional counterparts; however, incrementally better responses were again seen in more mesenchymally-shifted cell lines. …”
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    Epithelial-to-Mesenchymal Transition Enhances Cancer Cell Sensitivity to Cytotoxic Effects of Cold Atmospheric Plasmas in Breast and Bladder Cancer Systems
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