“…In spite of the differences in backscattering cross sections, the triple‐frequency signatures of heavily rimed particles resemble those of the homogeneous spheroids, thus explaining earlier observational results that were compatible with such spheroids.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Third, examples were presented wherein spheroids were produced using AT-MSCs for cartilage regeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Tissue clearing protocols, developed mostly for larger specimens usually involve multiple steps of viscous liquid submersion, and are not easily adaptable for much smaller spheroids and organoids. In this work, we have developed a novel tissue clearing solution tailored for small spheroids and organoids. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Cell spheroids and aggregates generated from three-dimensional (3D) cell culture methods are similar to in vivo tumors in terms of tissue morphology, biology, and gene expression, unlike cells grown in 2D cell cultures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the human metastatic melanoma HT-168 xenograft model the combined application of DBD and CDDP was also very effective, inducing a reduction in the number and volume of metastatic nodules. For V79 spheroids, DBD was mainly cytotoxic against the internal, quiescent cells, whereas cisplatin primarily killed cells in the proliferating, external regions of the spheroids. …”
Enlace del recurso
Enlace del recurso

“…Similar to in situ tumours, spheroids exhibit an approximately sigmoidal growth curve, often approximated and fitted by logistic and Gompertzian sigmoid functions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, gelatin microgels were formed from microfluidics droplets, stabilised by aldehydes and frozen into a spheroidal shape. Microgel morphology and response to external stimuli were characterised. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…HESC, as an unlimited source, can be successively propagated in spheroids. Here, we demonstrate that hESC spheroids can directly differentiate into MSC spheroids (EMSC(Sp)) within 20 days in one vessel without passaging and the system is scalable to any desired size. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To conclude, 3D culture of ucMSC in defined serum‐free KO‐medium formed viable spheroids which enabled the isolation of Exo(ucMSC) with the potential of accelerating wound healing.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, we used aqueous solutions of an emerging cryoprotectant, an artificial zwitterion supplemented with a conventional cryoprotectant, dimethyl sulfoxide (DMSO), for cell spheroids. The zwitterion/DMSO aqueous solutions produced a better cryoprotective effect on cell spheroids, which are the smallest units of tissues, compared to that of a commercial cryoprotectant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, cinobufagin induced apoptosis, increased the width of wounds, reduced invasive osteosarcoma spheroids/parent cell numbers and reduced EMT phenotype and OPN levels in U2OS/MG-63 spheroids as well as U2OS/MG-63 parent cells lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The NPs underwent spheroidization and phase transformation during the annealing process. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MSCs within untreated spheroids retain their mesenchymal spindle shape with abundant smooth muscle α-actin filaments and fibronectin-rich matrix. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Co-injection of NAB2-overexpressing CAFs with FaDu spheroids into mice enhanced the growth of tumors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Toward this, we recently demonstrated that the laterally confined growth of fibroblasts on micropatterned substrates induces stem-cell-like spheroids. In this study, we embedded these partially reprogrammed spheroids in collagen-I matrices of varying densities, mimicking different three-dimensional (3D) tissue constraints. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, cAMP upregulation in a culture of ADSCs in spheroids resulted in significantly increased osteocalcin production and mineralization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Also, an HUVEC monolayer was cocultured with cancer spheroids, and the endothelial permeability was monitored to evaluate the metastasis of the cancer spheroids. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Prostate epithelial cells from both normal and cancer tissues, grown in three-dimensional (3D) culture as spheroids, represent promising in vitro models for the study of normal and cancer-relevant patterns of epithelial differentiation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: The anchorage-independent spheroids from ovarian adenocarcinoma cell line 3AO were formed in a serum-free medium. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: γδ T cells rapidly responded to melanoma cells and infiltrated melanoma spheroids better than αβ T cells in PBMCs. Cancer‐associated fibroblasts (CAFs) in bicellular spheroids, stroma cells in multicellular melanoma spheroids and inhibitory immune cells in organoids significantly inhibited immune cell infiltrates including γδ T cells and lessened their cytotoxicity to tumour cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso