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  1. 3941
    “…In spheroids, the phosphorescence signal was detected at a depth of up to 60 μm using PLIM and showed a gradient in the intracellular O(2) level towards their center.…”
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    The Dual Luminescence Lifetime pH/Oxygen Sensor: Evaluation of Applicability for Intravital Analysis of 2D- and 3D-Cultivated Human Endometrial Mesenchymal Stromal Cells
  2. 3942
    “…Using a matrigel artificial basement membrane invasion assay, we demonstrated that sub-cyto-toxic doses of TQ (40μM) decreased C26 cell invasion by 50% and suppressed growth in three-dimensional spheroids. Apoptotic signs seen morphologically were increased significantly in TQ-treated spheroids. …”
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    Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
  3. 3943
    por Yonemura, Shigenobu
    Publicado 2014
    “…In R2/7 α-Cate cells, spheroids showed similar apical-basal polarity as that seen in MDCK II cells, but had multiple lumens. …”
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    Differential Sensitivity of Epithelial Cells to Extracellular Matrix in Polarity Establishment
  4. 3944
    “…In particular, we observed elevated levels of glycerophosphocholine (GPC) in CAL(R) relative to CAL(S) monolayers, spheroids and tumours, independent of the growth rate or environment. …”
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    Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous carcinoma cells and xenograft tumours
  5. 3945
    “…The attachment rate of BeWo cell spheroids to Ishikawa cells treated with rIL-10 was expressed as a percentage of the total number of spheroids. …”
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    Decreased Endometrial IL-10 Impairs Endometrial Receptivity by Downregulating HOXA10 Expression in Women with Adenomyosis
  6. 3946
    “…The nanoparticles were found to enhance cytotoxicity effects compared to those of free DR5-B in both 2D (monolayer culture) and 3D (tumor spheroids) in vitro models. The cytotoxicity of the nanoparticles was investigated in human cell lines, namely breast adenocarcinoma MCF-7 and colorectal carcinomas HCT116 and HT29. …”
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    Amphiphilic Poly(N-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells
  7. 3947
    “…RESULTS: The spheroids were cultivated for 20 days, fixed and analyzed using confocal microscopy. …”
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    Three-dimensional cell culture for the study of nasal polyps
  8. 3948
    “…Spheroids showed initial (autophagosomes) but not late (lysosomes) components of autophagy (incomplete autophagy). …”
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    Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson’s disease: removing axonal debris
  9. 3949
    “…Further experiments evaluated the growth of the enriched spheroids. BJ not only reduced the expression of stem cell markers but also eliminated tumor spheroids by apoptotic death. …”
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    The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis
  10. 3950
    “…Ir1‐HSA mainly accumulated in the nucleus of living cancer cells and showed remarkable photocytotoxicity against a range of cancer cell lines and tumor spheroids (light IC(50); 0.8–5 μm, photo‐cytotoxicity index PI=40–60), while remaining non‐toxic to normal cells and normal cell spheroids, even after photo‐irradiation. …”
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    Nucleus‐Targeted Organoiridium–Albumin Conjugate for Photodynamic Cancer Therapy
  11. 3951
    “…For instance, the asteroids (162173) Ryugu and (101955) Bennu have an oblate spheroidal shape with a pronounced equator, but contain different surface hydration levels. …”
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    Collisional formation of top-shaped asteroids and implications for the origins of Ryugu and Bennu
  12. 3952
    “…We establish a framework for cell culture, formation of tumor spheroids, fluorescence labeling, and imaging of fixed or live cells at various magnifications directly in the chip together with data analysis and interpretation. …”
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    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
  13. 3953
    “…MICs-enriched spheroids release high levels of adenosine and express the immunosuppressive cytokine IL-10, undetectable in an adherent cell counterpart. …”
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    CXCR4 Inhibition Counteracts Immunosuppressive Properties of Metastatic NSCLC Stem Cells
  14. 3954
    “…Objective: Here, we addressed the role of a new signaling axis involved in the regulation of in vitro spheroids formation and assessed the chemopreventive ability of diet-derived epigallocatechin gallate (EGCG) to impact the processes that govern the acquisition of spheroids CSC stemness traits. …”
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    A Signaling Crosstalk Links SNAIL to the 37/67 kDa Laminin-1 Receptor Ribosomal Protein SA and Regulates the Acquisition of a Cancer Stem Cell Molecular Signature in U87 Glioblastoma Neurospheres
  15. 3955
    “…Control proteomes from DIPG spheroids were compared with DIPG cells isolated from mosaic and assembloid co-cultures. …”
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    BIOL-09. PROTEOMIC ANALYSES REVEAL THAT CO-CULTURE OF DIFFUSE INTRINSIC PONTINE GLIOME (DIPG) WITH CORTICAL ORGANOIDS ALTERS CELL ADHESION, DNA SYNTHESIS AND REPLICATION, AND DENDRITIC GROWTH SIGNALLING
  16. 3956
    “…Despite a close morphology, colospheres displayed higher invasivity than did spheroids. Spheroids and colospheres migrated into Matrigel but matrix metalloproteinase (MMP)-2 and MMP-9 activity was detected only in colospheres. …”
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    Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness
  17. 3957
    “…Spheroids could be differentiated to gastric organoids after withdrawal of Wnt3A and R-spondin1 from the medium. …”
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    A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro
  18. 3958
    “…Next, we show that cells in the developing human cortex express the nociceptin opioid (NOP) receptor and that buprenorphine can signal through this receptor in cortical spheroids. Using subpallial spheroids to grow inhibitory interneurons, we show that buprenorphine can alter interneuron development and migration into the cortex. …”
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    Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex
  19. 3959
    “…The cells were cultured in a floater tissue culture plate to allow spheroids formation, and then the spheroids were collected and transferred to a scaffold spheroids dish. …”
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    3-Dimensional coculture of breast cancer cell lines with adipose tissue–Derived stem cells reveals the efficiency of oncolytic Newcastle disease virus infection via labeling technology
  20. 3960
    por Koh, Isabel, Hagiwara, Masaya
    Publicado 2023
    “…We also describe the processes for cryo and paraffin sectioning of spheroids in CUBE to retain gradient orientation information. …”
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    Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation
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