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  1. 4021
    “…This report describes a patient who developed a spheroidal calculus with a central part composed of potassium urate, surrounded by a continuous layer of calcium oxalate monohydrate with crystals of calcium oxalate dihydrate on the surface. …”
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    Rare non-papillary lithiasis of calcium oxalate monohydrate generated on a central core of potassium urate
  2. 4022
    “…Most importantly, in vitro 3D co-culture spheroidal sprouting assay was used to investigate the regulating role of vascular endothelial growth factor (VEGF)-angiopoietin (Ang)-Tie2 signaling on angiogenic sprouting in 3D co-cultured spheroids of HUVECs and T-DPSCs. …”
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    DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling
  3. 4023
    “…Analysis of RTX-treated spheroids demonstrated apoptosis and necrosis essentially in the outer cell-layers. …”
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    Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma
  4. 4024
    “…The bacteriobots showed higher migration velocity toward tumor cell lysates or spheroids than toward normal cells. In addition, when only the bacteriobots were injected to the CT-26 tumor mouse model, Cy5.5 signal was detected from the tumor site of the mouse model. …”
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    New paradigm for tumor theranostic methodology using bacteria-based microrobot
  5. 4025
    “…Long-term growth in serial xenografts and spheroids was driven by multiple genomic subclones with profoundly differing growth dynamics and hence different quantitative contributions over time. …”
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    Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
  6. 4026
    “…Collagen-nanocellulose hydrogels supported the growth of tumour spheroids and multicellular 3D cultures, with increased metabolic activity and matrix stiffness. …”
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    3D Collagen-Nanocellulose Matrices Model the Tumour Microenvironment of Pancreatic Cancer
  7. 4027
    “…The present studies were conducted to evaluate key serum proteins and other components that mediate anchorage-independent growth (3-D growth) of LNCaP prostate cancer cells as spheroids. The cells were cultured on ultra-low attachment plates in the absence and presence of fetuin-A and with or without extracellular vesicles. …”
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    Fetuin-A Promotes 3-Dimensional Growth in LNCaP Prostate Cancer Cells by Sequestering Extracellular Vesicles to Their Surfaces to Act as Signaling Platforms
  8. 4028
    “…The three-dimensional morphology changes of fine eutectic Si-particles in both cast alloys, specifically fragmentation and spheroidizing, can be connected to changes in mechanical properties.…”
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    Observation of Morphology Changes of Fine Eutectic Si Phase in Al-10%Si Cast Alloy during Heat Treatment by Synchrotron Radiation Nanotomography
  9. 4029
    por Sperlich, Julia, Teusch, Nicole
    Publicado 2018
    “…Furthermore, pseudopterosin inhibited the invasion of MDA-MB-231 3D tumor spheroids embedded in an extracellular-like matrix. …”
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    Pseudopterosin Inhibits Proliferation and 3D Invasion in Triple-Negative Breast Cancer by Agonizing Glucocorticoid Receptor Alpha
  10. 4030
    “…Here we compare two derivative cancer models, microtumors and spheroids, to the gold standard model of patient-derived orthotopic xenografts (PDX) in glioblastoma multiforme (GBM). …”
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    A Novel Assay for Profiling GBM Cancer Model Heterogeneity and Drug Screening
  11. 4031
    “…Changes in mitochondrial activity were also associated with the spheroids taking up fLG. To better understand these phenomena, we review here the Warburg effect as well as key studies regarding glucose uptake. …”
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    L-Glucose: Another Path to Cancer Cells
  12. 4032
    “…The assay allows analysis of cell adhesion, polarity and lumen formation of epithelial spheroids. Pkhd1 silencing critically affects the initial phase of the morphogenesis assay, leading to a reduction of correctly polarized spheroids by two thirds. …”
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    Fibrocystin Is Essential to Cellular Control of Adhesion and Epithelial Morphogenesis
  13. 4033
    por Wilson, Emily S., Litwa, Karen
    Publicado 2021
    “…Hyaluronan localizes to the synaptic cleft of developing excitatory synapses in both human cortical spheroids and the neonatal mouse brain and is diminished in the adult mouse brain. …”
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    Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
  14. 4034
    “…The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated uptake is reported. This is important because most orthodox systems, including polycationic cell-penetrating peptides, fail to deliver efficiently into deep tissue. …”
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    Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue
  15. 4035
    “…Due to the synergistic effect of its interconnected micro-nano structures, the resultant system could not only precisely control the size of cell spheroids but also realize adequate nutrient supply of cell spheroids. …”
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    Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction
  16. 4036
    “…CONCLUSIONS/IMPORTANCE: The present case revealed the spontaneous avulsion of the pterygium head leading to the corneal epithelial defects and ocular pain, while the pterygium head of the fellow eye showed subepithelial hyper-reflective foci suspicious of spheroidal degeneration on AS-OCT. In this case, the cause of spontaneous avulsion of the pterygium head might be potentially weak adhesion to the cornea due to spheroidal degeneration. …”
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    A case of spontaneous avulsion of primary pterygium analyzed with anterior segment optical coherence tomography
  17. 4037
    por Takae, Kyohei, Kawasaki, Takeshi
    Publicado 2022
    “…By utilizing the coupling between the spheroidal orientations and the elastic fields, these topological phases are switched by temperature, external electromagnetic fields, and anisotropic stresses, where a re-entrant phase transition between the helical and the half-skyrmion phases is discovered. …”
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    Emergent elastic fields induced by topological phase transitions: Impact of molecular chirality and steric anisotropy
  18. 4038
    “…RESULTS: When highly and weakly migratory cells are co-seeded in mixed spheroids, the weakly migratory cells migrated farther than weakly migratory only spheroids. …”
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    Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism
  19. 4039
    “…A novel dataset of twelve spheroids was introduced to the public. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-022-04827-3.…”
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    Marker-controlled watershed with deep edge emphasis and optimized H-minima transform for automatic segmentation of densely cultivated 3D cell nuclei
  20. 4040
    “…The transformable LPNs exhibited enhanced capacity of penetration in contrast to the un-transformable preparations in three-dimensional (3D) tumor spheroids. Furthermore, synergetic penetrating enhancement was achieved by LST-loaded transformable LPNs in 4T1 and fibroblast cell mixed 3D tumor spheroids. …”
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    Multifunctional ROS-Responsive and TME-Modulated Lipid-Polymer Hybrid Nanoparticles for Enhanced Tumor Penetration
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