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  1. 4181
    “…Comparison of lung cancer cell spheroids that formed in the presence of sera from bonded and bond-disrupted deer mice showed that in monogamous Peromyscus polionotus and Peromyscus californicus, but not in polygamous Peromyscus maniculatus, the disruption of pair bonds altered the size and morphology of spheroids in a manner that is consistent with the acquisition of increased oncogenic potential. …”
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    Persistent effects of pair bonding in lung cancer cell growth in monogamous Peromyscus californicus
  2. 4182
    por Salerno, Dominick, Sofou, Stavroula
    Publicado 2021
    “…We studied TNBC cells with variable chemosensitivities, in the absence (on monolayers) and presence (in 3D multicellular spheroids) of transport barriers; we compared the combined killing effect of free doxorubicin and free cisplatin to the killing effect (1) of conventional liposomal forms of the two chemotherapeutics, and (2) of tumor-responsive lipid nanoparticles (NP), specifically engineered to result in more uniform spatiotemporal microdistributions of the agents within solid tumors. …”
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    Growth Inhibition of Triple-Negative Breast Cancer: The Role of Spatiotemporal Delivery of Neoadjuvant Doxorubicin and Cisplatin
  3. 4183
    “…TGF-β2 and hypoxia significantly and synergistically increased the barrier function of the 2D HRPE monolayers, as evidenced by TEER measurements, the downsizing and stiffening of the 3D HRPE spheroids and the mRNA expression of most of the ECM proteins. …”
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    Hypoxia Differently Affects TGF-β2-Induced Epithelial Mesenchymal Transitions in the 2D and 3D Culture of the Human Retinal Pigment Epithelium Cells
  4. 4184
    “…Neither an obvious mass change nor a visible energy change was observed within the tested temperature range, indicating high phase stability of the LC powder and its suitability for TBC applications. Spheroidization on the prepared LC powders was also investigated, revealing that powder size and morphology had a significant impact on the spheroidization efficiency.…”
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    Synthesis and Characterization of Fluorite-Type La(2)Ce(2)O(7) Plasma Sprayable Powder for TBCs Application
  5. 4185
    “…Results: MIRDcell V3 effectively reproduces experimental responses of multicellular spheroids to uniform and nonuniform distributions of therapeutic radiopharmaceuticals. …”
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    MIRD Pamphlet No. 27: MIRDcell V3, a Revised Software Tool for Multicellular Dosimetry and Bioeffect Modeling
  6. 4186
    “…Notably, Schwann cells grew into larger spheroids in RGD-free PIC than in PIC-RGD, while HL-7702 showed the opposite behavior. …”
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    Synthetic Extracellular Matrices for 3D Culture of Schwann Cells, Hepatocytes, and HUVECs
  7. 4187
    “…The application of CMC cryogels to 3D co-culture HEK-293T spheroids with P. fluorescence revealed a higher resistance of human cells to bacterial toxins than in the 2D co-culture.…”
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    Chitosan versus Carboxymethyl Chitosan Cryogels: Bacterial Colonization, Human Embryonic Kidney 293T Cell Culturing and Co-Culturing
  8. 4188
    “…Amongst others, fluorescence microscopy and spectroscopy, as well as cell death studies were applied for liposomal, 2D and 3D in vitro models including tumor spheroids without or within skin models and in vivo mouse xenografts. …”
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    In Model, In Vitro and In Vivo Killing Efficacy of Antitumor Peptide RDP22 on MUG-Mel2, a Patient Derived Cell Line of an Aggressive Melanoma Metastasis
  9. 4189
    “…This study explored these cells in both 2D flat layers and 3D structures called spheroids. In spheroids, the regulation process of internal acidity appears to work differently than in 2D. …”
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    Characterization of the Intracellular Acidity Regulation of Brain Tumor Cells and Consequences for Therapeutic Optimization of Temozolomide
  10. 4190
    “…Using a specific siRNA IMP1, we analyzed cell death and cell cycle progression in PDAC cell lines and 3D spheroids. The role of IMP1 was also evaluated in vivo in a Panc-1-derived tumor xenograft murine model. …”
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    Insulin-like Growth Factor II mRNA-Binding Protein 1 Regulates Pancreatic Cancer Cell Growth through the Surveillance of CDC25A mRNA
  11. 4191
    “…Upon culturing equivalent hepatocytes in the MPS, spheroids, and sandwich cultures, differences between culture formats were detected in CYP3A4 activity and albumin production. …”
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    Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation
  12. 4192
    “…The aim of this study was to determine if acute (24 h) and prolonged (120 h) exposures to five ENMs (TiO(2), ZnO, Ag, BaSO(4) and CeO(2)) would have a significantly different toxicological outcome (cytotoxicity, (pro-)inflammatory and genotoxic response) upon 3D human HepG2 liver spheroids. In addition, this study evaluated whether a more realistic, prolonged fractionated and repeated ENM dosing regime induces a significantly different toxicity outcome in liver spheroids as compared to a single, bolus prolonged exposure. …”
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    Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver
  13. 4193
    por Acciari, V.A., Ansoldi, S., Antonelli, L.A., Arbet Engels, A., Baack, D., Babić, A., Banerjee, B., Barres de Almeida, U., Barrio, J.A., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colak, S.M., Colin, U., Colombo, E., Contreras, J.L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M.V., Font, L., Fruck, C., Fukami, S., García López, R.J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, D., Green, J.G., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Mićanović, S., Miceli, D., Miener, T., Minev, M., Miranda, J.M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J.M., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P.G., Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F.G., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., Vagelli, V., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C.F., Vitale, V., Vovk, I., Will, M., Zarić, D.
    Publicado 2020
    “…We present the first results from very-high-energy observations of the dwarf spheroidal satellite candidate Triangulum II with the MAGIC telescopes from 62.4 hours of good-quality data taken between August 2016 and August 2017. …”
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    A search for dark matter in Triangulum II with the MAGIC telescopes
  14. 4194
    “…MCL spheroids, integrated by tumor B cells, monocytes and autologous T-cells self-organize in disc-shaped structures, where B and T-cells maintain viability and proliferate, and monocytes differentiate into M2-like macrophages. …”
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    A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses
  15. 4195
    “…The controlled assembly of spheroids allows to translate organoid morphogenesis to a macroscopic scale, generating vascularized centimeter‐scale beige adipose micro‐tissues. …”
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    Scalable Generation of Pre‐Vascularized and Functional Human Beige Adipose Organoids
  16. 4196
    “…Paclitaxel also proved to be remarkably effective in preventing invasion in a co-culture system in which tumour spheroids were confronted with fetal rat brain cell aggregates. …”
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    Proliferation, migration and invasion of human glioma cells exposed to paclitaxel (Taxol) in vitro.
  17. 4197
    “…Three-dimensional cartilage-like constructs, called single spheroids, and microtissues consisting of several spheroids fused together, named as fusions, were formed. …”
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    Three-Dimensional Scaffold-Free Fusion Culture: the Way to Enhanced Chondrogenesis of in vitro Propagated Human Articular Chondrocytes
  18. 4198
    “…When cultured in Rotary Cell Culture System (RCCS), Sertoli cells, formed multicellular three dimensional spheroids (3D). Biological properties were first analyzed in terms of viability, cell cycle, expression of cytoskeletal components and growth factors in comparison to Sertoli cells cultured in spheroids at unit gravity (G). …”
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    Effect Of Microgravity On Aromatase Expression In Sertoli Cells
  19. 4199
    “…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to create mixed cell spheroids. Cardiac patches were created from spheroids (CM:FB:EC = 70:15:15, 70:0:30, 45:40:15) using a 3D bioprinter. …”
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    Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
  20. 4200
    “…This difference in CAIX expression in hypoxia was consistent with a varying activity of FIH-1 between the cell lines. 3D expression analysis demonstrated that both CAIX and NHE1 were up-regulated in the hypoxic areas of multicellular tumor spheroids. However, the induction of CAIX expression in hypoxia was again cell line dependent. 3D invasion assays conducted with spheroids showed that CAIX inhibition significantly reduced the invasion of cells. …”
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    Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells
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