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  1. 4201
    “…A predominance of plate-like minerals or radially oriented plate-like crystallites within spheroidal minerals in the proximal intratubular locations, and core-shell type crystallites within spheroidal minerals in distal interstitial locations were observed. …”
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    Architecture-Guided Fluid Flow Directs Renal Biomineralization
  2. 4202
    “…We showed that TSC2(NEG) cells have acquired a transformed phenotype as showed by their ability to grow as spheroids in semi-solid medium and that unlike endothelin receptors antagonists, rapamycin reduced anchorage-independent cell growth and prevented expansion of TSC2(NEG) spheroids.…”
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    Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration
  3. 4203
    “…Despite having a limited effect on L929 normal cells, OEO/thymol induced cytotoxicity in MDA-MB231 breast cancer monolayers (2D) and to a lesser extent in MDA-MB231 spheroids (3D). Flow cytometry, caspase-3 activity assay in treated monolayers/spheroids and also fluorescence staining and DNA fragmentation in treated monolayers demonstrated apoptotic death mode. …”
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    In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA
  4. 4204
    “…Human bone marrow stromal cell (HBMSC) and HUVEC spheroids were implanted within a bone defect site to determine the osteogenic potential of the skeletal–endothelial cell unit. …”
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    3D human bone marrow stromal and endothelial cell spheres promote bone healing in an osteogenic niche
  5. 4205
    “…Their excellent cell-permeable properties allowed for efficient staining of three-dimensional cell spheroids, and thereby phosphorescence lifetime measurements enabled the evaluation of the O(2) level and distribution in spheroids, including the detection of alterations in O(2) levels by metabolic stimulation with an effector. …”
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    In vivo O(2) imaging in hepatic tissues by phosphorescence lifetime imaging microscopy using Ir(III) complexes as intracellular probes
  6. 4206
    “…We used a 3D co-culture model of cancer cell spheroids from the KPC (LSL-Kras(G12D/+)/LSL-Trp53(R172H/+)/p48-Cre) pancreatic ductal adenocarcinoma (PDAC) model, to examine interactions with tumor-educated T cells isolated from draining lymph nodes of PDAC-bearing mice. …”
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    Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity
  7. 4207
    “…Spheroidal carbonaceous particles (SCPs) are a component of fly-ash, the particulate by-product of industrial high temperature combustion of fuel-oil and coal-series fuels. …”
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    First evidence of industrial fly-ash in an Antarctic ice core
  8. 4208
    “…We describe steps for neuroectoderm differentiation, development of neural spheroids, and their transferal to Matrigel. We then detail procedures for the development, maturation, and application of oligodendrocyte-enriched brain organoids. …”
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    Protocol for generating embedding-free brain organoids enriched with oligodendrocytes
  9. 4209
    “…A mesoscopic methylammonium lead iodide (CH(3)NH(3)PbI(3)) perovskite/TiO(2) heterojunction solar cell is developed with low-cost carbon counter electrode (CE) and full printable process. With carbon black/spheroidal graphite CE, this mesoscopic heterojunction solar cell presents high stability and power conversion efficiency of 6.64%, which is higher than that of the flaky graphite based device and comparable to the conventional Au version.…”
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    Full Printable Processed Mesoscopic CH(3)NH(3)PbI(3)/TiO(2) Heterojunction Solar Cells with Carbon Counter Electrode
  10. 4210
    “…We finally show that thaspine induces wide-spread apoptosis in colon carcinoma multicellular spheroids and that apoptosis is induced in two xenograft mouse models in vivo. …”
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    Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters
  11. 4211
    “…Finally, after a 24-hour gemcitabine treatment, the cell viability in spheroids was reduced by 92% as opposed to 51% in presence of AGA. …”
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    Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy
  12. 4212
    por Thatte, Shreya
    Publicado 2011
    “…Improved epithelialization and stromal healing was noted in corneal ulcer cases. In spheroidal degenerations, keratectomy with AMT improved vision. …”
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    Amniotic membrane transplantation: An option for ocular surface disorders
  13. 4213
    “…We have applied these methods to evaluate the sensitivity of normal and tumorigenic breast epithelial cell lines against a panel of oncology drugs when cultured as monolayers (2D) and spheroids (3D). We have identified two classes of compounds that exhibit preferential cytotoxicity against cancer cells over normal cells when cultured as 3D spheroids: microtubule-targeting agents and epidermal growth factor receptor (EGFR) inhibitors. …”
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    3-Dimensional Culture Systems for Anti-Cancer Compound Profiling and High-Throughput Screening Reveal Increases in EGFR Inhibitor-Mediated Cytotoxicity Compared to Monolayer Culture Systems
  14. 4214
    “…Focal Adhesion Kinase (FAK) and cofilin phosphorylation, and RhoA Guanosine Triphosphatase (GTPase) activity were all enhanced in these spheroids compared to control acini. Importantly, inhibition of either FAK or Rho Kinase (ROCK) was sufficient to rescue the polarity defect. …”
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    Essential Function for PDLIM2 in Cell Polarization in Three-Dimensional Cultures by Feedback Regulation of the β1-Integrin–RhoA Signaling Axis()()
  15. 4215
    “…OPN was highly expressed in side population fractions of HCC cell lines, as well as in dormant cells, spheroids and chemo-resistant cancer cells, all of which are considered as having stemness-like cellular features. …”
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    Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF-κB–HIF-1α pathway
  16. 4216
    “…We are able to illustrate the transition from spheroidal drops with a strong indentation on the rotation axis to toroidal drops that do not extend to the rotation axis. …”
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    On the Stability of Rotating Drops
  17. 4217
    “…Autophagy was studied in mesothelioma cell lines, as 2-dimensional (2D) monolayers and 3-dimensional (3D) multicellular spheroids (MCS), and in tumor from 25 chemonaive patients, both as ex vivo 3D tumor fragment spheroids (TFS) and as formalin-fixed tissue. …”
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    Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome
  18. 4218
    por LI, Ying, Lu, Liyuan, LI, Juan
    Publicado 2016
    “…After splenectomy, the cells were larger, but still spheroidal-shaped. The membrane ultrastructure was disorganized and characterized by a reduced surface particle size and lower than normal Ra values. …”
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    Topological Structures and Membrane Nanostructures of Erythrocytes after Splenectomy in Hereditary Spherocytosis Patients via Atomic Force Microscopy
  19. 4219
    “…RESULTS: Higher ezrin expression was found in cells composing the spheroids compared to their counterparts cultured on alginate scaffold and in clinical samples of malignant effusions compared to solid tumors. …”
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    Ezrin Is Associated with Disease Progression in Ovarian Carcinoma
  20. 4220
    “…Our results showed that both Brassicaceae extracts and ITCs exert antiproliferative effects in HT29 spheroids, arresting cell cycle at G(2)/M, possibly due to ITC-induced DNA damage. …”
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    Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study
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