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  1. 4241
    “…Using these cells, we measured cytotoxicity by several anti-tumor agents (2D), cellular metabolism including mitochondrial and glycolytic functions by a Seahorse bio-analyzer (2D), the physical properties, size and stiffness of the 3D spheroids, trypsin sensitivities (2D and 3D), and RNA sequencing analysis (2D). …”
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    G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells
  2. 4242
    “…The effect of Pep-1-Phor21 on the viability of prostate cancer cells grown in monolayers (2D) and microtissue spheroids (3D) was assessed via CellTox green cytotoxic assay. …”
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    Targeting of the Interleukin-13 Receptor (IL-13R)α2 Expressing Prostate Cancer by a Novel Hybrid Lytic Peptide
  3. 4243
    “…Both methods are used in a way that makes it unnecessary to assume that the plasmas are spheroidal, and it is shown that they are not. Good agreement between the two methods illustrates the possibility to accurately determine plasma densities and geometries within non-idealized, realistic trapping potentials.…”
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    Density and geometry of single component plasmas
  4. 4244
    “…We found that the tumor-infiltrated cells alone were unable to form tumor spheroids, even with increased amounts and time. By contrast, the tumor-infiltrated cells together with PCa cells formed large numbers of tumor spheroids compared with PCa cells alone. …”
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    Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase
  5. 4245
    “…FUT3 knockdown in RL95-2 cells significantly decreased the expression of sLeA and the spheroids adhesion to endometrial monolayer. Anti-sLeA antibody can remarkably suppress both the basal and IL-1β induced adhesion of HTR-8/SVneo spheroids to RL95-2 cells monolayer. …”
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    Targeting Aberrantly Elevated Sialyl Lewis A as a Potential Therapy for Impaired Endometrial Selection Ability in Unexplained Recurrent Miscarriage
  6. 4246
    “…Day 6 blastocysts were co-cultured with Ishikawa cell layers until Day 8, and human TSC spheroids modelling blastocyst trophectoderm were co-cultured with Ishikawa cell layers for 48 h. …”
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    Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation
  7. 4247
    “…METHODS AND RESULTS: Here we demonstrate that spheroids isolated from human and murine healthy pancreas and co-transplanted orthotopically with pancreatic ductal adenocarcinoma (PDAC) in mouse pancreas inhibited tumor growth. …”
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    Fibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth
  8. 4248
    “…Substantial numbers of axonal spheroids were also labeled with LC3 in NHD brains. …”
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    LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
  9. 4249
    por Ishikawa, Yoshie, Koshizaki, Naoto
    Publicado 2018
    “…Extrapolating the data obtained from a 20-ml suspension, the average production rate was determined as 195 mg h(−1). The high spheroidizing ratio and yield through the slit nozzle is attributable to the uniquely slow but continuous liquid film flow. …”
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    Guided Slow Continuous Suspension Film Flow for Mass Production of Submicrometer Spherical Particles by Pulsed Laser Melting in Liquid
  10. 4250
    “…Here, we demonstrate that DCLK1-overexpressing primary human hepatocytes formed spheroids in suspension cultures. Spheroids derived from DCLK1-overexpressing hepatoma cells showed high level expression of active β-catenin, α-fetoprotein, and SOX9, suggesting that DCLK1 overexpression induces clonogenicity and dedifferentiated phenotypes in hepatoma cells. …”
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    Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism
  11. 4251
    “…Similarly, niclosamide exhibits high activity against BHGc7 TOS and UHGc5 TOS but not against the other CTC spheroids. High expression of the CSC marker CD133 was restricted to three SCLC tumor lines and the BHGc10 CTC line. …”
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    Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines
  12. 4252
    “…One of these concepts is the biological meaning of the small, spheroidal vesicles released from cells, which are described in the literature as microparticles, microvesicles, or exosomes. …”
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    Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?
  13. 4253
    “…Proteomic analysis of EOC 3D-spheroids revealed decreased protein synthesis and mTOR signaling, upon MDM4 expression. …”
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    Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties
  14. 4254
    “…Caspase 3/7 activation and loss of structural integrity were also observed in CRC cell lines grown as spheroids. Drug treatment at clinically relevant concentrations significantly reduced the viability of patient-derived CRC organoids. …”
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    The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing
  15. 4255
    “…Anchorage-independent 3D-cultures of multicellular tumour spheroids (MCTS) and in vitro microtumours of cancer cells can provide upfront information on the effects of anticancer drug candidates, tantamount to that obtained from animal xenograft studies. …”
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    3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors
  16. 4256
    por Sellwood, J A
    Publicado 1980
    “…The global bar stability of the disc is not greatly affected by the interaction between the two stellar populations, and it is found that a large fraction of the total galactic mass is still required in the spheroidal component if bar formation is to be prevented. (36 refs).…”
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    Galaxy models with live halos
  17. 4257
    “…Magnetic Resonance Imaging (MRI) of the brain revealed enlargement of the third ventricle and presence of a large spheroidal neoplasm in the sellar/parasellar region suggestive of a pituitary macroadenoma. …”
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    A rare case of pituitary chromophobe carcinoma in a dog: clinical, tomographic and histopathological findings
  18. 4258
    “…It was found that as the traverse speed increased, spheroidization, refinement, and a more homogeneous distribution of these precipitates occurred.…”
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    The Effect of the Traverse Feed Rate on the Microstructure and Mechanical Properties of Laser Deposited Fe(3)Al (Zr,B) Intermetallic Alloy
  19. 4259
    “…We are also reporting the protocol for tumor-derived explant cultures to develop oral cancer cell lines and enriching these diverse hybrid states of cancer cells in 3D spheroids from established cell lines. For complete details on the use and execution of this protocol, please refer to Vipparthi et al. (2022) and Vipparthi et al. (2021).…”
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    Characterizing diversity among human oral stem-like cancer cells using flow cytometry
  20. 4260
    “…Proliferative and invasion abilities of spheroids formed by co-culturing MTV/TM-011 breast cancer cells and adipocytes-Grem2 were significantly reduced compared to those of spheroids formed by co-culturing MTV/TM-011 cells and adipocytes-mock. …”
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    The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis
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