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  1. 4301
    “…Biological tests showed that the viability of MDA-MB-231 and MCF-7 cancer cells is decreased following C. cancellatus treatment in a time- and dose-dependent way in both monolayer and 3D cell cultures. The MCF-7 cell spheroids had greater resistance to the cytotoxic activity of the extract in 3D cell culture than the MDA-MB-231 cell spheroids. …”
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    Untargeted Metabolomics Analysis of Crocus cancellatus subsp. damascenus (Herb.) B. Mathew Stigmas and Their Anticarcinogenic Effect on Breast Cancer Cells
  2. 4302
    “…Stable ERRα overexpression in H295R cells promoted a better mitochondrial fitness and prompted toward a more aggressive phenotype characterized by higher Vimentin expression, enhanced cell migration and spheroids formation. By contrast, a decrease in ERRα protein levels, by molecular (short hairpin RNA) and pharmacological (inverse agonist XCT790) approaches modified the energetic status toward a low energy profile and reduced Vimentin expression and ability to form spheroids. …”
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    Estrogen Related Receptor Alpha (ERRα) a Bridge between Metabolism and Adrenocortical Cancer Progression
  3. 4303
    “…In contrast, ATRA induced the formation of substantially downsized and softer 3D spheroids in the absence and presence of TGF-β2. The different effects induced by ATRA toward 2D and 3D HTM cells were also supported by the qPCR analysis of several proteins as above. …”
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    All-trans Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM Cells
  4. 4304
    “…[Image: see text] Spheroidal cancer microtissues are highly advantageous for a wide range of biomedical applications, including high-throughput drug screening, multiplexed target validation, mechanistic investigation of tumor–extracellular matrix (ECM) interactions, among others. …”
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    Droplet Microfluidics-Based Fabrication of Monodisperse Poly(ethylene glycol)-Fibrinogen Breast Cancer Microspheres for Automated Drug Screening Applications
  5. 4305
    “…The viability of B16 (3D) spheroids after treatment with SBA-NBDH and SBA-NBD-PD was evaluated using MTS assay. …”
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    Novel Antitumor Agents Based on Fluorescent Benzofurazan Derivatives and Mesoporous Silica
  6. 4306
    “…Dorsal skinfold chambers (DSFC) were installed on wild-type mice, and PancOVA H2B-Cerulean tumor cells were implanted into the chambers. PancOVA spheroids were formed using the Corning(®) Matrigel(®)-based 3D cell culture technique. …”
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    IL18 Receptor Signaling Inhibits Intratumoral CD8(+) T-Cell Migration in a Murine Pancreatic Cancer Model
  7. 4307
    “…Mathematical analyses of spheroids growth and morphology confirm the similarity with GBM patients. …”
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    A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma †
  8. 4308
    “…In addition, the concentrations of the three TGF-β isoforms also caused diverse effects on the physical properties of 3D HTM spheroids and the mRNA expression of ECMs and their modulators, in many of which, the effects of TGF-β-3 were markedly different from TGF-β-1 and TGF-β-2. …”
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    TGF-β-3 Induces Different Effects from TGF-β-1 and -2 on Cellular Metabolism and the Spatial Properties of the Human Trabecular Meshwork Cells
  9. 4309
    por Dyson, J. E., Daniel, J., Surrey, C. R.
    Publicado 1992
    “…Concentrations of 0.010 mM and above cause fragmentation of, and increased cell shedding from, multicell spheroids, suggesting an effect on the cell surface. …”
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    The effect of sodium butyrate on the growth characteristics of human cervix tumour cells.
  10. 4310
    “…METHODS: This was a prospective phase II trial with a clinical intervention comprising biopsy for culturing spheroids and their subsequent administration (level of evidence: I). …”
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    Safety of three different product doses in autologous chondrocyte implantation: results of a prospective, randomised, controlled trial
  11. 4311
    “…Hereditary diffuse leukoencephalopathy with spheroids (HDLS) [also known as adult onset leukoencephalopathy with spheroids and pigmented glia (ALSP)] is a neurodegenerative disorder primarily affecting cerebral white matter, most often caused by mutations of CSF1R. …”
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    Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
  12. 4312
    “…Depletion of LPIAT1 in cultured hepatic cells and in spheroids caused triglyceride accumulation and collagen deposition. …”
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    LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover
  13. 4313
    “…BACKGROUND: CSF1R-related encephalopathy refers to adult-onset leukodystrophy with neuroaxonal spheroids and pigmented glia (ALSP) due to CSF1R mutations, which is a rare autosomal dominant white matter disease including two pathological entities, hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD). …”
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    Three novel mutations in Chinese patients with CSF1R-related leukoencephalopathy
  14. 4314
    “…Under 3D confinement, lymphoma B cells were able to form cohesive spheroids resulting from overexpression of ECM components. …”
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    A novel 3D culture model recapitulates primary FL B-cell features and promotes their survival
  15. 4315
    “…The dynamics of the GBM spheroids was examined using high-content imaging for 60 h, and four metrics including invasion distance, invasion area, single-cell invasion velocity, and directionality were employed to quantify the invasion capacity. …”
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    Novel Brain-Stiffness-Mimicking Matrix Gel Enables Comprehensive Invasion Analysis of 3D Cultured GBM Cells
  16. 4316
    “…General indenter shapes are considered, and the load–indentation curves that result for a range of spheroidal tips are obtained for both flat and curved membranes. …”
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    Axisymmetric indentation of curved elastic membranes by a convex rigid indenter
  17. 4317
    “…According to a Prognoscan database, upregulation of Bruton's tyrosine kinase (Btk) is associated with low overall survival in ovarian cancer patients. We found that spheroids-forming ovarian cancer cell, which highly expressed cancer stem-like cell (CSC) markers and Btk, were cisplatin resistant. …”
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    Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer
  18. 4318
    “…The configurations combine the advantages stemming from the elongation and reduced metal volume of hollow spheroids and the wide tunability and good antenna efficiency due to hybridization of composite modes on the core–shell dimers. …”
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    Enhancing Diamond Color Center Fluorescence via Optimized Configurations of Plasmonic Core–Shell Nanoresonator Dimers
  19. 4319
    por Fang, Ye, Eglen, Richard M.
    Publicado 2017
    “…In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. …”
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    Three-Dimensional Cell Cultures in Drug Discovery and Development
  20. 4320
    por Hartmann, R. R., Portnoi, M. E.
    Publicado 2017
    “…For the symmetric case, the eigenfunctions of the supercritical states are expressed as spheroidal wave functions, and approximate analytical expressions are obtained for the corresponding eigenvalues. …”
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    Two-dimensional Dirac particles in a Pöschl-Teller waveguide
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