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  1. 4321
    “…We pair this detector with the lightsheet illumination technique, and apply it to 3D FLIM imaging of dye gradients in human cancer cell spheroids, and C. elegans. [Image: see text]…”
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    Lightsheet fluorescence lifetime imaging microscopy with wide‐field time‐correlated single photon counting
  2. 4322
    “…With a comprehensive neuronal differentiation protocol comprised of mechanical and biochemical inductive cues, we investigated the capacity of spontaneously forming stem cell spheroids (SCS) from cultured WJ stromal cells in regard to their neuronal differentiation potential and compared them to undifferentiated spheroids or adherent MSCs. …”
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    In Vitro Simulated Neuronal Environmental Conditions Qualify Umbilical Cord Derived Highly Potent Stem Cells for Neuronal Differentiation
  3. 4323
    “…The pons of alpha-galactosidase A-deficient mice in particular exhibited a striking neuropathological phenotype, including the presence of large, swollen axonal spheroids indicating axonal degeneration, in addition to large interstitial aggregates positive for phosphorylated alpha-synuclein that co-localized with the axonal spheroids. …”
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    Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice
  4. 4324
    “…To accelerate translation research, increasing interest has been focused on using in vivo-like models such as three-dimensional spheroids. The development of higher throughput assays to quantify phenotypic changes in spheroids is an active research area. …”
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    Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid Treatment
  5. 4325
    “…We used clonogenic assays, mice xenograft models and patient-derived 3D spheroids to validate the results. The induction of DNA damage was studied by immunofluorescence. …”
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    Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer
  6. 4326
    “…METHODS: T-cell penetration was demonstrated in tumor spheroids using confocal microscope, and in xenografted tumors by histology and in vivo real-time fluorescence imaging. …”
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    Bifunctional iRGD-anti-CD3 enhances antitumor potency of T cells by facilitating tumor infiltration and T-cell activation
  7. 4327
    “…During short-term 2D culture, WNT4 expression and secretion declined in neoplastic pTECs but not in 3D spheroids or medium supplemented with recombinant WNT4 cultures. …”
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    WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro
  8. 4328
    “…In this review, we highlight the potential applications of tumor spheroids and organoids in the field of urology. Further, we illustrate the generation and characteristics of standardized organoids as well as membrane-based 3D in vitro models in bladder cancer research. …”
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    3D Tumor Models in Urology
  9. 4329
    “…Five high-grade (3 grade III and 2 grade IV) astrocytoma tumour cell populations were treated with a preparation of Human Leukocyte Interferon either in monolayer cell culture or as multicellular spheroids in vitro or as xenografts growing in immune-deprived mice in vivo. …”
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    The failure of human leukocyte interferon to influence the growth of human glioma cell populations: in vitro and in vivo studies.
  10. 4330
    “…Our experiments show that the most regular structures are formed using cylinders and cuboids and not by spheroids. This simple design rule will help the self-assembly community to realize three-dimensional crystals from objects in the micrometer range, which opens up the way toward previously unknown metamaterials.…”
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    Three-dimensional self-assembly using dipolar interaction
  11. 4331
    “…Our quantization conditions also enable us to find exact expressions of eigenvalues of spin-weighted spheroidal harmonics. We test the validity of our conjecture by comparing against known numerical results for Kerr black holes as well as for Schwarzschild black holes. …”
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    Black Hole Quasinormal Modes and Seiberg–Witten Theory
  12. 4332
    por Li, Tong, Okada, Nobuchika, Shafi, Qaisar
    Publicado 2018
    “…The boost factor has a tension with the Fermi-LAT data for gamma-ray from dwarf spheroidal galaxies and the limit from CMB anisotropies, which can be ameliorated with enhanced local DM density by a factor of about two.…”
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    Type II seesaw mechanism with scalar dark matter in light of AMS-02, DAMPE, and Fermi-LAT data
  13. 4333
    “…The pre-treatment of spheroids with ScF, followed by cell irradiation with X-ray and treatment with SpD (three-component treatment) at low non-toxic concentrations, led to significant inhibition of the spheroids’ viability and invasion and appeared to be the most effective therapeutic scheme for SK-MEL-2 cells. …”
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    Combined Radiomodifying Effect of Fucoidan from the Brown Alga Saccharina cichorioides and Pacificusoside D from the Starfish Solaster pacificus in the Model of 3D Melanoma Cells
  14. 4334
    “…GFRa2+-cells form non-endocrine spheroids in culture. These spheroids can be differentiated to hormone-producing cells or neurons outlining the neuroectoderm potential of these progenitors. …”
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    A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary
  15. 4335
    “…Cell-cell adhesion was analyzed by the ability of cells to form spheroids. We also investigated BMP-2 expression in tissue samples from a series of EOC patients. …”
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    BMP-2 signaling in ovarian cancer and its association with poor prognosis
  16. 4336
    “…This new genus contains 16- or 32-celled spheroidal colonies similar to those of the volvocine genera Yamagishiella and Eudorina. …”
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    New “missing link” genus of the colonial volvocine green algae gives insights into the evolution of oogamy
  17. 4337
    “…In vitro internalization and anticancer efficacy were evaluated in the MDA-MB-231 cells using multicellular tumor spheroids, CyQUANT and MTT assays. These NCs were orally delivered in a breast cancer xenograft mice model, and their internalization, cytotoxicity, biodistribution, and anticancer efficacy were evaluated. …”
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    Oral administration of iron-saturated bovine lactoferrin–loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism
  18. 4338
    “…Results: We demonstrated that 4-DACL displayed high activity against different malignant melanoma cells and melanoma spheroids and only low toxicity to melanocytes and other primary cells. …”
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    Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB
  19. 4339
    “…Tumors produced from these cell lines showed no expression of the N-cadherin protein. Spheroids which are made up of putative cancer initiating cells produced from these cell lines showed only background expression of N-cadherin mRNA, increased expression of aldehyde dehydrogenase 1 mRNA and produced tumors which did not express N-cadherin. …”
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    Loss of N-Cadherin Expression in Tumor Transplants Produced From As(+3)- and Cd(+2)-Transformed Human Urothelial (UROtsa) Cell Lines
  20. 4340
    “…MDR1A KO CD19+ B cells, but not WT CD19+ B cells, suppressed growth of colonic tumor-derived spheroids from AOM/DSS-WT mice in an ex-vivo co-culture system, implying that B-cell regulated immune responses contributed to delayed tumor development in MDR1A deficiency. …”
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    MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis
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