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  1. 4341
    por Niu, N, Mercado-Uribe, I, Liu, J
    Publicado 2017
    “…Morphologically, early spheroids derived from PGCCs were indistinguishable from human embryos at the blastomere, polyploid blastomere, compaction, morula and blastocyst-like stages by light, scanning electron or three-dimensional confocal scanning microscopy. …”
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    Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells
  2. 4342
    “…Because platelet-derived GroPro® stood out amongst the non-FBS growth supplements to allow proliferation without inducing spheroids, it seems the best (mindful that the cells still grew slower in it compared to FBS). …”
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    Human Cells Grown With or Without Substitutes for Fetal Bovine Serum
  3. 4343
    “…Our results have important implications for using e-CSCs, especially those derived from 3D-spheroids, (i) in tumor tissue bio-banking and (ii) as a new cellular platform for drug development.…”
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    “Energetic” Cancer Stem Cells (e-CSCs): A New Hyper-Metabolic and Proliferative Tumor Cell Phenotype, Driven by Mitochondrial Energy
  4. 4344
    “…To elucidate the mechanism underlying these effects of COA-Cl on cardiac myocytes, pure hiPSC-CM spheroids were evaluated in the presence/absence of Suramin (antagonist of A1R). …”
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    2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids
  5. 4345
    “…SIMPLE SUMMARY: Three-dimensional (3D) culture of tumor spheroids (TSs) within the extracellular matrix (ECM) recapitulates solid tumors in vivo. …”
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    Three-Dimensional Imaging for Multiplex Phenotypic Analysis of Pancreatic Microtumors Grown on a Minipillar Array Chip
  6. 4346
    “…We specifically encapsulated tri-cellular spheroids made from A549 cells, HUVECs, and human lung fibroblasts, for simulating solid type lung cancer. …”
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    Three-Dimensional Vascularized Lung Cancer-on-a-Chip with Lung Extracellular Matrix Hydrogels for In Vitro Screening
  7. 4347
    “…OV-90 cells cultured in large spheroids were sensitive to the inhibitors and displayed a robust synergistic antiproliferative response to the inhibitor combination. …”
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    The Anti-Proliferative Effect of PI3K/mTOR and ERK Inhibition in Monolayer and Three-Dimensional Ovarian Cancer Cell Models
  8. 4348
    “…Cells of the human breast cancer cell line MCF-7 demonstrated good uptake of anticancer-drug-loaded nanocarriers after 6 h. Similarly, MCF-7 spheroids showed good uptake of the anticancer-drug-loaded aggregates after 72 h. …”
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    Polyphosphazene-Based Nanocarriers for the Release of Camptothecin and Epirubicin
  9. 4349
    “…In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of aggressive, but not nonaggressive, tumor cells to form networks surrounding spheroids of tumor cells in three-dimensional culture; these recapitulate the patterned networks seen in patients' aggressive tumors and correlates with poor prognosis. …”
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    Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells
  10. 4350
    “…We highlight two dynamic modes: a tunable periodic state that oscillates between two defect configurations on a spherical shape and a tunable rotating state for oblate spheroids. We further demonstrate the relation between defects and high Gaussian curvature and umbilical points and point out limits for a coarse-grained description of defects as self-propelled particles.…”
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    Curvature controlled defect dynamics in topological active nematics
  11. 4351
    “…Herein, superparamagnetic single-phase magnetite nanoparticles of hexagonal and spheroidal-shape, with an average size of ca. 15 nm, are generated by laser ablation of bulk iron metal at 1064 nm in a vortex fluidic device (VFD). …”
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    Laser-Ablated Vortex Fluidic-Mediated Synthesis of Superparamagnetic Magnetite Nanoparticles in Water Under Flow
  12. 4352
    “…This species is distinguished from others in the section by the large number of sperm packets in its monoicous sexual spheroids and by the long spines on its zygote wall. …”
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    A new preferentially outcrossing monoicous species of Volvox sect. Volvox (Chlorophyta) from Thailand
  13. 4353
    “…This minireview will focus on mass spectrometry-based proteomics studies applied specifically to colorectal cancer, particularly the variety of cancer model systems used, including tumor samples, two-dimensional (2D) and three-dimensional (3D) cell cultures such as spheroids and organoids. A thorough discussion of the application of these systems will accompany the review of the literature, as each provides distinct advantages and disadvantages for colorectal cancer research. …”
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    Proteomics of Colorectal Cancer: Tumors, Organoids, and Cell Cultures—A Minireview
  14. 4354
    “…They are found to exist in globular clusters, open clusters, dwarf spheroidal galaxies of the Local Group, OB associations and as field stars. …”
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    Ecology of blue straggler stars
  15. 4355
    “…Inspired by the formation of natural spheroids such as pebbles, we developed non-interfacial self-assembly (NISA) of microdroplets as a step toward synthetic protocells, in which the inert perfluorocarbon was utilized to reshape the hydrogel through the scouring action. …”
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    Non-interfacial self-assembly of synthetic protocells
  16. 4356
    “…The stiffness of IPF-derived spheroids was reduced by PF670462 and TGF-β-induced fibrogenic gene expression was inhibited. …”
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    Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis
  17. 4357
    “…METHODS: Twelve patient-derived GSC lines were screened at 10 µM, as multicellular spheroids, in a 384-well serum-free assay with 133 FDA-approved compounds. …”
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    Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma
  18. 4358
    “…The treatment with staurosporine caused a reduction of the size of MEN1(+/+) MEFs spheroids. Instead, MEN1(−/−) MEFs spheroids did not show any significant reduction of their size. …”
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    Exploring the MEN1 dependent modulation of caspase 8 and caspase 3 in human pancreatic and murine embryo fibroblast cells
  19. 4359
    “…In co-cultures of MPM and endothelial cells, P31 spheroids permitted endothelial sprouting (ES) with minimal spatial distortion, whereas SPC111 spheroids repealed endothelial sprouts. …”
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    Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow
  20. 4360
    “…Here, we expand upon this work and examine the combination of Ru-PIP with Olaparib for synergy in lung cancer cells, including in 3D lung cancer spheroids, to further elucidate mechanisms of synergy and additionally assess toxicity in a zebrafish embryo model. …”
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    Synergy of ruthenium metallo-intercalator, [Ru(dppz)(2)(PIP)](2+), with PARP inhibitor Olaparib in non-small cell lung cancer cells
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