“…We also present similar constraint coming from the recent XMM-Newton observation of Ursa Minor -- dark, X-ray quiet dwarf spheroidal. Although this observation has relatively poor statistics, the constraints are comparable to those, recently obtained using observations of Large Magellanic Cloud or M31. …”
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“…The austenitization of 100CrMnSi6-4 bearing steel in two initial states was compared—after accelerated spheroidization annealing and conventional soft annealing. …”
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“…The instability mechanism actually at play results from the hydrodynamic fluid-body coupling made possible by the unconstrained motion of the bubble which behaves essentially, in the relevant size range, as a rigid, nearly spheroidal body on the surface of which water slips freely.…”
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“…Herein we show an accessible technique based on Faraday waves that assist the rapid assembly of osteoinductive β-Tricalcium phosphate (β-TCP) particles as well as human osteoblast pre-assembled in spheroids. The hydrodynamic forces originating at ‘seabed’ of the assembly chamber can be used to tightly aggregate inorganic and biological entities at packing densities that resemble those of native tissues. …”
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“…Here, we report on the use of 3D bioprinting to incorporate these structures in engineered skin tissues. Spheroids, induced by printing dermal papilla cells (DPCs) and human umbilical vein cells (HUVECs), were precisely printed within a pregelled dermal layer containing fibroblasts. …”
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“…Peripherin, a neuronal intermediate filament protein associated with axonal spheroids in amyotrophic lateral sclerosis (ALS), induces the selective degeneration of motor neurons when overexpressed in transgenic mice. …”
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“…The dynamic physiological response of tissues to applied drugs is the basis for a new type of phenotypic profiling for drug screening on multicellular tumor spheroids. Volumetrically resolved tissue-response fluctuation spectrograms act as fingerprints that are segmented through feature masks into high-dimensional feature vectors. …”
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“…We find that the dense GPS array truly detected both spheroidal and toroidal fundamental modes in three-direction displacement. …”
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“…In between these irregular strands of trabeculae with plump osteoblast, spheroidal ossicles with basophilic in center and eosinophilic in periphery resembling psammoma-like bodies are noticed.…”
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“…Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by severe axonal swelling (spheroids) throughout the nervous system. In dogs, NAD has been reported in several breeds and a missense mutation in PLA2G6 gene has recently been identified in the Papillon dog NAD. …”
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“…For neuroblastoma, a developmental malignancy of the neural crest, it is possible to establish patient-derived models as xenografts in mice and zebrafish, and as spheroids and organoids in vitro. These varied approaches have contributed to comprehensive packages of preclinical evidence in support of new therapeutics for neuroblastoma. …”
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“…Furthermore, it attenuated the formation of spheroids and the self-renewal capacities of ovarian cancer stem cells and exerted an antiangiogenic effect. …”
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“…In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. …”
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“…In this review, we provide an overview of the recent advances in different 3D culture systems, including spheroids, organoids, and “organ-on-a-chip” models, and their use in analysing the crucial role of Notch signalling in the maintenance of tissue homeostasis, pathology, and regeneration.…”
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“…We revisit the viability of the CMSSM, searching for regions of parameter space that yield a neutralino dark matter density compatible with Planck measurements, as well as LHC constraints including sparticle searches and the mass of the Higgs boson, recent direct limits on spin-independent and -dependent dark matter scattering from the LUX-ZEPLIN (LZ) experiment, the indirect constraints from Fermi-LAT and H.E.S.S. on dark matter annihilations to photons in dwarf spheroidal galaxies and the Galactic Centre, and the IceCube limits on muons from annihilations to neutrinos in the Sun. …”
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“…To that aim, we incorporated an in vitro system of non-adherent spheroids from primary adrenocortical mouse cells that were stimulated with ACTH. …”
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“…The overall effect involves the Al matrix softening and the spheroidization of eutectic Si caused by prolonged exposure to high temperature. …”
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“…We have therefore studied the cytotoxicity of HMA in combination with nigericin, a cell-acidifying agent, for EMT-6 cells in monolayer cell culture, in spheroids and in a murine tumour model. The combination of nigericin and HMA was toxic to cells in tissue culture at extracellular pH (pHe) < or = 6.8 (as may be found in tumours) but not at pH 7.0 or above (as in most normal tissues). …”
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“…Moreover, carnosine significantly inhibited the growth of three-dimensional spheroids and tumor xenografts compared with untreated controls. …”
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“…CONCLUSION: Basolateral exposure of spheroids to plasma of IBS-D patients resulted in a significantly increased FD4 permeation, which was partially abolished by selective inhibition of tryptase and LPS. …”
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