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  1. 4381
    “…In addition, OVCAR3 and KURAMOCHI SUSD2-KD spheroids displayed increased mesothelial clearance ability compared with cells that express endogenous levels of SUSD2. …”
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    SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance
  2. 4382
    “…Upon detachment on low-binding dishes, parental cells initially formed rounded spheroids with limited growth activity. However, over time in cultures, cells gradually formed smaller spheroids that grew slowly, and, after 3–4 months, we obtained FL sublines that regained prominent growth potential in suspension cultures. …”
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    Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures
  3. 4383
    “…In HD tumors, enhanced distribution relative to unmodified NPs was measured for MPG and PEG NPs in HeLa, and for all modified NPs in SiHa spheroids. In LO tumors, the greatest distribution was observed for MPG and MPG/PEG NPs in HeLa, and for PEG and MPG/PEG NPs in SiHa spheroids. …”
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    Distribution of PLGA-modified nanoparticles in 3D cell culture models of hypo-vascularized tumor tissue
  4. 4384
    “…Finally, we examined the migration of iDC in tumor cell spheroids, a tissue-like 3D environment. We observed that iDC infiltrated spheroids of tumor cells using both migration modes. …”
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    Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells
  5. 4385
    “…Drug treatment of PDX spheroids was performed to determine if genes activated in metastases may identify targetable mediators of viability. …”
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    Separation of breast cancer and organ microenvironment transcriptomes in metastases
  6. 4386
    “…Finally, we evaluated the expansion of HACY-induced CD24(+) cells in human hepatocyte-spheroids from fibrotic liver tissues. Results: HepLPCs exhibited the capacity to alleviate liver fibrosis after transplantation into CCL4-treated mice. …”
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    The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction
  7. 4387
    “…Here we studied pseudoislets of Langerhans, which are three-dimensional spheroids composed of β (INS1E), α (alpha TC-1), and endothelial (HUVEC) cells, and were interested in how the location and prevalence of the different cell types affected the presence of endothelial cells in the pseudoislet. …”
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    The Role of Alpha Cells in the Self-Assembly of Bioengineered Islets
  8. 4388
    “…Results: Our studies indicated that only spheroids from the U87 cell line have impaired growth after treatment with both compounds, suggesting an increased resistance from T98G spheroids, contrary to what was observed in the monolayer culture, which highlights the need to employ 3D models for future GBM studies. …”
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    Cobaltabis(dicarbollide) ([o-COSAN](−)) as Multifunctional Chemotherapeutics: A Prospective Application in Boron Neutron Capture Therapy (BNCT) for Glioblastoma
  9. 4389
    “…However, the size of tumor spheroids was smaller than the untreated controls, indicating their proliferation was suppressed after S7333 treatment. …”
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    Inhibition of colon cancer K-Ras(G13D) mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway
  10. 4390
    “…Thus, the results of the cellular spheroids viability showed that they were significantly more resistant to the cytotoxic action of MAg NPs and their gel formulation than 2D cell culture. …”
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    Gel with silver and ultrasmall iron oxide nanoparticles produced with Amanita muscaria extract: physicochemical characterization, microstructure analysis and anticancer properties
  11. 4391
    “…The inhibition effect on the SMMC-7721 tumor spheroids was studied and penetration ability was evaluated by CLSM. …”
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    tLyP-1 Peptide Functionalized Human H Chain Ferritin for Targeted Delivery of Paclitaxel
  12. 4392
    “…Cardiotoxicity in vitro was evaluated in human ether-a-go-go related gene (hERG)-potassium channel-overexpressing cells by the patch-clamp method and by assessing key parameters in 3D cardiac spheroids. Cytotoxicity was determined in H1299, HepG2 and SH-SY5Y cell lines. …”
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    A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects
  13. 4393
    “…Findings were correlated with clinical parameters and histological findings of acute axonal damage (APP-positive spheroids) and axonal loss in different lesion stages. …”
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    Neurofilament light chains in serum as biomarkers of axonal damage in early MS lesions: a histological–serological correlative study
  14. 4394
    por Smeyers, Paul, Van Hoolst, Tim
    Publicado 2010
    “…The first part of the book presents basic concepts and equations, the distinction between spheroidal and toroidal normal modes, the solution of Poisson’s differential equation for the perturbation of the gravitational potential, and Hamilton’s variational principle. …”
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    Linear Isentropic Oscillations of Stars: Theoretical Foundations
  15. 4395
    por Matteucci, Francesca
    Publicado 2012
    “…In the core of the book, the construction and solution of chemical evolution models are discussed in detail, followed by descriptions and interpretations of observations of the chemical evolution of the Milky Way, spheroidal galaxies, irregular galaxies and of cosmic chemical evolution. …”
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    Chemical evolution of galaxies
  16. 4396
    “…Its localization in the outer layer of the Blue–DTAB co-assembly explains the uniaxial growth of spheroidal DTAB micelles to wormlike micelles with increasing [Blue] : [DTAB] ratio from 0 : 1 to 1 : 3. …”
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    SANS contrast matching for the unambiguous localization of anionic dye in cationic surfactant micelles
  17. 4397
    “…Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. …”
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    The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
  18. 4398
    por Mirkovic, Djordje, Zrnic, Dusan S.
    Publicado 2023
    “…The rough hailstone scattering library is created to fill the need for results of non-spheroidal hailstone backscattering characteristics. …”
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    Library of rough hailstone backscattering coefficients at 2.8 GHz
  19. 4399
    “…This technique has been used to identify zones of chronically hypoxic cells in multicellular spheroids and animal tumours. Tritiated-misonidazole was administered to a patient with advanced melanoma 22 h prior to the surgical resection of a large metastatic s.c. lesion growing on the face. …”
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    A novel technique for measuring human tissue pO2 at the cellular level.
  20. 4400
    “…The major portion of the nucleolar volume was composed of compact, particulate material. Spheroidal fibrillar zones about 0.4 µ in diameter occurred within the particulate mass. …”
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    DISTINCTIVE CHARACTERISTICS OF NUCLEOLI OF TWO ESTABLISHED CELL LINES
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