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  1. 4441
    “…Human activity was recorded there from cal AD 1958 (±6). Anthropogenic spheroidal aluminosilicates clearly identify the beginning of industrial development and are proposed as a new indicator of the Anthropocene. …”
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    Anthropogenic- and natural sources of dust in peatland during the Anthropocene
  2. 4442
    “…Pantothenate kinase- associated neurodegeneration (PKAN) syndrome is a rare autosomal recessive disorder characterized by progressive extrapyramidal dysfunction and iron accumulation in the brain and axonal spheroids in the central nervous system. It has been shown that the disorder is caused by mutations in PANK2 gene which codes for a mitochondrial enzyme participating in coenzyme A biosynthesis. …”
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    A Novel Nonsense Mutation in PANK2 Gene in Two Patients with Pantothenate Kinase-Associated Neurodegeneration
  3. 4443
    “…Working with a simplified numerical model of tumour spheroids, we investigated the impact of mechanical heterogeneity on the onset of tumour invasion into surrounding tissues. …”
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    Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination
  4. 4444
    por Radu, Dobrescu, Victor, Purcărea
    Publicado 2009
    “…The modeling solution is able to reproduce the classic three-layer structure familiar from multicellular spheroids: cell proliferation, quiescent and necrosis. …”
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    Network based models for biological applications
  5. 4445
    por Chujo, Takeshi, Hirose, Tetsuro
    Publicado 2017
    “…Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. …”
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    Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function
  6. 4446
    por Qiao, Han, Tang, Tingting
    Publicado 2018
    “…In this review, multicellular tumour spheroids and bioreactors, tissue engineering constructs and scaffolds, microfluidic systems and 3D bioprinting technology are discussed to explore the progression of the 3D engineering approaches used to model the three microenvironments of bone metastasis. …”
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    Engineering 3D approaches to model the dynamic microenvironments of cancer bone metastasis
  7. 4447
    “…Using microimplantation of breast cancer spheroids into the murine mammary fat pad and live-cell monitoring, we show microenvironmental conditions and cytoskeletal adaptation during collective to single-cell transition in vivo. …”
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    Intravital microscopy of collective invasion plasticity in breast cancer
  8. 4448
    “…Last, an untargeted metabolic comparison revealed that breast cancer spheroids grown in Plasmax approximate the metabolic profile of mammary tumors better. …”
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    Improving the metabolic fidelity of cancer models with a physiological cell culture medium
  9. 4449
    “…The shell is made of white cast iron, alloyed with Ni and Cr, and the core is manufactured of grey cast iron spheroidal graphite in a pearlitic matrix. It is thus advisable to inoculate the shell with 0.6 kg/T SiCaMn, as this promotes discontinuity in the carbide network and leads to an increase in the impact toughness of the bond interface. …”
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    Enhancement of the Quality of the Shell-Core Bond Interface in Duplex Work Rolls Manufactured by Centrifugal Casting Used in Hot Strip Mills
  10. 4450
    “…We demonstrate the ability of the system to fate-map hypoxic cells in 2D, and in 3D spheroids and organoids. We identify distinct gene expression patterns in cells that experienced intratumoral hypoxia in vivo compared to cells exposed to hypoxia in vitro. …”
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    Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
  11. 4451
    por Otipka, Petr, Vlček, Jaroslav
    Publicado 2019
    “…Derived depolarization factors for discs and bi-cone particles are compared with the early known shapes (spheroids, cylinders) and applied to nanostructures composed of the Fe or Au nanodots in polyacrylate.…”
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    Shape Dependent EMA Model of Nanostructured Anisotropic Materials
  12. 4452
    “…These mouse-passaged (mp) PHH cultures overcome the marked donor-to-donor variability of cryopreserved PHH and remain functional for months as demonstrated by metabolic assays and infection with hepatitis B virus and Plasmodium falciparum. mpPHH can be efficiently genetically modified in culture, mobilized, and then recultured as spheroids or retransplanted to create highly humanized mice that carry a genetically altered hepatocyte graft. …”
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    Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes
  13. 4453
    “…It was found that lamellar Al(11)RE(3) precipitates spheroidized with the introduction of Ti(2)AlC into the AE44 matrix. …”
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    Processing and Mechanical Properties of Ti(2)AlC MAX Phase Reinforced AE44 Magnesium Composite
  14. 4454
    “…Melanoma cells lacking functional Elkin1 exhibit defective mechanoelectrical transduction, decreased motility and increased dissociation from organotypic spheroids. By analysing cell adhesion properties, we demonstrate that Elkin1 deletion is associated with increased cell-substrate adhesion and decreased homotypic cell-cell adhesion strength. …”
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    TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration
  15. 4455
    “…We recently established co-culture models of hetero-spheroids including primary human PSCs and PDAC cells showing their importance as a platform to test the effects of cancer- and stroma-targeted drugs. …”
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    Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models
  16. 4456
    “…Additionally, these thio-based PSs lack dark cytotoxicity but exhibit significant phototoxicity against monolayer cancer cells and 3D multicellular tumor spheroids with IC(50) in the micromolar range. To achieve tumor-specific delivery, we have conjugated these thio-based PSs to an antibody and demonstrated their tumor-specific therapeutic activity.…”
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    Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy
  17. 4457
    “…Finally, we discuss the possibility to design sophisticated 3D tissue-like DNA-gels incorporating cell spheroids or single cells for the assembly of a novel kind of cellular matrix as a preclinical investigation for the implementation of tools for in vivo delivery of bioactive molecules.…”
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    DNA-GEL, Novel Nanomaterial for Biomedical Applications and Delivery of Bioactive Molecules
  18. 4458
    por Pezda, Jacek, Jezierski, Jan
    Publicado 2020
    “…As a result, HBS10/1000/30 hardness in the range of 105–130 was obtained, which means an increase from 35% to 60% in comparison to the as-cast, depending on the position of the measurement and spheroidization of precipitations of eutectic silicon.…”
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    Non-Standard T6 Heat Treatment of the Casting of the Combustion Engine Cylinder Head
  19. 4459
    “…In this review, we focused on the most widely used 3D human glioblastoma models, including spheroids, tumorospheres, organotypic slices, explants, tumoroids and glioblastoma-derived from cerebral organoids. …”
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    Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation
  20. 4460
    “…Floating spheroidal aggregates of mouse embryonic stem cells can develop into polarized/elongated organoids, namely gastruloids. …”
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    Gastruloid Development Competence Discriminates Different States of Pluripotency
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