“…The device provides a live ‘window’ into the microenvironment and could be used to study cancer cells for which it is difficult to generate tumour spheroids. Another major application of the device is the study of effects of the microenvironment on cellular drug responses. …”
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“…Several cancer cell stemness markers, such as ABCG2, OCT-4, CD133, ALDH1, CD9, MRP1 and connexin were upregulated in mortalin-overexpressing cells that showed higher ability to form spheroids. These cells also showed higher migration, and were less responsive to a variety of cancer chemotherapeutic drugs. …”
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“…Determination of the structure of such aggregates by X-ray crystallography revealed a spheroidal particle formed by 24 protein monomers. Oligomerization is triggered by refolding of the N-terminus. …”
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“…Cultured pericytes were capable of smooth muscle lineage progression including inducible expression of smooth muscle myosin heavy chain, calponin, and α-smooth muscle actin, and adopted a spindle shape. Pericytes formed spheroids when cultured on Matrigel substrates and peripherally localized with branching endothelial cells in vitro. …”
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“…In addition, nanolization also enhanced the penetration ability and inhibitory effect of the Pt complex toward MCF7 breast cancer-cell tumor spheroids. The enhancement of anticancer efficacy was positively correlated with increased cellular uptake and cellular drug retention. …”
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“…In the current study, RDX was re-crystallized and spheroidized to form the high-quality RDX that was further characterized by purity, apparent density, size distribution, specific surface area, impact sensitivity, and shock sensitivity. …”
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“…Here, we report the in vitro generation of enterospheres (hEnS) from hPSC-derived gastrointestinal epithelial precursors. hEnS are cystic spheroids with a simple uniform structure composed entirely of intestinal epithelium. hEnS express markers of mature brush border cells and share a transcriptome profile similar to that of more mature intestinal organoids. …”
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“…Solution crystallization of a polycarbonate surface is carried out to generate a hydrophobic surface with hierarchical texture composed of micro/nanosize spheroids and fibrils. Functionalized nanosize silica particles are deposited on the textured surface to reduce contact angle hysteresis. …”
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“…A decreased clonogenic survival was observed when hypoxic H460 3D spheroids were incubated with our lead compound. These novel compounds are therefore promising agents for CA IX-specific therapy.…”
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“…Here, we generate precardiac spheroids with pluripotent stem cells (PSCs) harboring GFP/RFP reporters under the control of FHF/SHF markers, respectively. …”
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“…These activated Vδ2 T cells kill CRC cells and tumor spheroids, and are able to migrate toward CRC cells in a microfluidic system. …”
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“…Accordingly, anti-cancer drug screenings and toxicology studies based on multicellular 3D biological models, the so-called “-oids” (e.g. spheroids, tumoroids, organoids), are blooming in the literature. …”
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“…While nontoxic in the dark, these compounds are phototoxic in various 2D monolayer cells, 3D multicellular tumor spheroids and are able to eradicate a multiresistant tumor inside a mouse model upon clinically relevant 1-Photon and 2-Photon excitation.…”
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“…We also report the assembly of tissue-like 3D spheroids containing the nanoreactors and demonstrate that they can perform the reactions in a repeated manner.…”
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“…Controlling the strength and coupling of the auxiliary potential ultimately determining the hybridized mode, we successfully demonstrate the global 2D homogenization of axial B(1)(+) for a simplified cylindrical phantom and for a more realistic phantom of spheroidal geometry. The mode-shaping potentials with a magnetic permeability or material loss are also tested to offer additional degrees of freedom in the selection of materials as well as in the manipulation of the B(1)(+) distribution, opening up the possibility of B(1)(+) homogenization for 3D MRI scanning.…”
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“…We show that DX1 is toxic to spheroids derived from primary PTEN-deficient glioblastoma (GBM), and crosses the BBB to suppress the growth of orthotopic GBM and breast cancer brain metastases. …”
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“…The in vivo acute oral toxicity data showed that the LD(50) values are greater than 2000 mg/kg for both the SiO(2) and TiO(2) nanoparticles; however, the SiO(2) and TiO(2) nanoparticles induced cytotoxicity in two-dimensional CCD-18Co cells and three-dimensional CCD-18Co spheroids and human colon organoids, with IC(50) values of 0.6, 0.8 and 0.3 mM for SiO(2) and 2.5, 1.1 and 12.5 mM for TiO(2) nanoparticles, respectively. …”
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“…However, current protocols yield either complex but highly heterogeneous aggregates (‘organoids’) or 3D structures with less physiological relevance (‘spheroids’). Here, we present a scalable, HTS-compatible workflow for the automated generation, maintenance, and optical analysis of human midbrain organoids in standard 96-well-plates. …”
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“…Here, we exploit the aqueous two-phase separation of dextran-in-PEG emulsion micro-droplets for the capture, spatial organization and immobilization of algal cells or algal/bacterial cell communities to produce discrete multicellular spheroids capable of both aerobic (oxygen producing) and hypoxic (hydrogen producing) photosynthesis in daylight under air. …”
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“…NLC obtained were nano-sized, monodisperse, negatively charged, and spheroidal-shaped, showing a suitable drug payload and thermal stability. …”
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