“…Multicellular tumour spheroids (MTS) from 4 mouse tumours (Line 1 lung carcinoma; a fibrosarcoma, FSA; a mammary carcinoma, MCa-11; and SV40-transformed fibroblasts, SV-A31) WEre injected into the abdominal cavity of normal, immunized or tumour-bearing syngeneic mice, recovered after 4-48 h, and their growth measured in vitro for 7-16 days. …”
Enlace del recurso
Enlace del recurso

“…The nucleoli first assume the form of spheroids which then become extended into ring or necklace shapes that are DNase-sensitive; in mature oocytes the nucleoli revert to a spheroidal form. …”
Enlace del recurso
Enlace del recurso

“…METHODS: Using non transformed non dissociated bronchial epithelium obtained by bronchial brushings from COPD and non-COPD smokers, we developed a 3-dimensional culture model, bronchial epithelial spheroids (BES). BES were analyzed by videomicroscopy, light microscopy, immunofluorescence, and transmission electron microscopy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Patterns of fluorescence in Chinese hamster V79 spheroids also indicated that internal hypoxic cells were less able to metabolise the drug; toxicity was observed in cells only when cell fluorescence exceeded about 500 times background. …”
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Most alterations in gene expression were directly related to mechanisms of the cytotoxics actions in OC spheroids. However, the induction of genes linked to mechanisms of DNA replication and repair in cisplatin- and topotecan-treated OC spheroids could be associated with immediate adaptive response to treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the present study, multicellular prostate tumour spheroids were treated with non-lethal direct current (DC) electrical fields, and uptake and toxicity of doxorubicin were investigated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…EMT6 spheroids 275–350 μ m in diameter were incubated in 0.1–15 mM aminolevulinic acid (ALA) or 0.001–2 mM ALA-hexylester (h-ALA) to test the ability of both pro-drugs to diffuse into the spheroids and induce PpIX production. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we present a combined in vivo tumor spheroid and shell-less CAM three-dimensional model for use in quantitative and qualitative analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multicellular tumor spheroids are an important in vitro model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the internal workings and organization of tumors at a critical phase of their development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODOLOGY/PRINCIPAL FINDINGS: We generated spheroids composed of fibroblasts alone, or composite spheroids, composed of fibroblasts and tumor cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrate accurate determination of the size and shape of spherical and spheroidal scatterers through inverse analysis of two-dimensional solid-angle and depth resolved backscattered light intensities. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Current models suggest that spheroids form by aggregation of single tumor cells shed from the primary tumor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the current study, rat adipose-derived adult stem cells (ASCs) grown on chitosan membranes were observed to form cell spheroids after 3 days. The cell seeding density and surface modification of chitosan with Arg-Gly-Asp–containing peptide had an influence on the sizes of ASC spheroids. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Three-dimensional (3D) multicellular spheroids of mesenchymal stem cells (MSCs) are generally regarded to have beneficial properties over MSCs in monolayer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This in vitro model was developed by the induction of reversal of multicellular spheroids that were generated by anchorage-independent growth. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Notably, two types of satellite spheroids also formed in deep hemispherical microchannels through self-aggregation and acted as an anchoring point to enhance formation of nerve-like networks with neighboring spheroids. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Zinc sulfophthalocyanine (ZnPcS(mix)) has been shown to be effective in A549 monolayers, multicellular tumor spheroids (MCTSs) (250 µm) and not on MCTSs with a size of 500 µm. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Multi-lumen spheroids of CSPP1 siRNA transfectants showed disrupted apical cell junction localization of the cytoskeleton organizing RhoGEF ECT2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso