“…Moreover, the spatial organization of ER-PM contacts is conserved in epithelial spheroids, suggesting that ER-PM contacts may serve conserved roles in epithelial cell architecture. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, HA@MOF@GSK-J1 demonstrated higher induction of apoptosis, reduced cell motility, and diminished cell spheroids by attenuating HER2 activity through the effectual activation of H3K27 methylation in its promoter area. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These two CAPs caused the shrinkage of WERI-Rb1 tumor spheroids (p ≤ 0.01), induced intrinsic apoptosis in WERI-Rb1 cells via activation of caspase 9 and caspase 3, cleaved the PARP protein, and triggered off the phosphorylation of p53 and γH2A.X. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this paper, we studied the role of the crystal structure in spheroidal CdSe nanocrystals on the band-edge exciton fine structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, the cytotoxicity of the Akt inhibitor perifosine and the Bcl‐2/Bcl‐xL inhibitor ABT‐737 was tested in colon cancer HT‐29 and HCT‐116 cells cultured in monolayer or in the form of spheroids. The efficacy of single drugs and their combination was analysed in different tumour‐specific environments including acidosis and hypoxia using a series of viability assays. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the current study, we isolated EVs from trophoblast analogue JAr spheroids and supplemented the EVs with receptive endometrium analogue RL95-2 cells to simulate pre-implantation embryo–maternal dialogue. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The latter was represented via trial-by-trial stochastic generation of astroglial and neuronal elements in the brain neuropil (overlapping spheroids of varied sizes), rather than using the ‘average’ morphology, thus reflecting the probabilistic nature of neuropil architectonics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Depending on the tasks and capabilities, a scientific laboratory can choose from several types of models: primary cell cultures, immortalized cell lines, spheroids or heterospheroids, tissue engineering models, bioprinted models, organoids, tumor explants, and histocultures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The eye of Aplysia californica was studied by electrophysiological and histological methods. It has a central spheroidal lens which is surrounded by a retina composed of several thousand receptor cells which are replete with clear vesicles, pigmented support cells, neurons which contain secretory granules, and glial cells. …”
Enlace del recurso
Enlace del recurso

“…The double-microelectrode voltage clamp technique was applied to small spheroidal aggregates of heart cells from 7-d chick embryos. …”
Enlace del recurso
Enlace del recurso

“…Approximately a third of the tumors examined were found to contain spheroidal bodies of uniform size and distinctive morphology that are believed to be virus particles. …”
Enlace del recurso
Enlace del recurso

“…The determination of mass per unit area, and calculation of total dry mass per cell were simplified by changing the shape of the cells to spheres which were then flattened to discs of constant thickness when smeared on glass slides for measurement of fixed cells by interferometry, and to oblate spheroids when smeared on parlodion-coated slides for measurement of fixed cells by x-ray absorption. …”
Enlace del recurso
Enlace del recurso

“…In addition, the multicellular spheroids of MTC-SK were destroyed and the cell morphology was changed by ST-2. …”
Enlace del recurso
Enlace del recurso

“…Remarkably, phylogenetic analysis suggests that the shift from simple to complex, differentiated multicellularity was not a unique progression in the evolution of life, but in fact a quite frequent event. The spheroidal green alga Volvox and its close relatives, the volvocine algae, span the full range of organizational complexity, from unicellular and colonial genera to multicellular genera with a full germ–soma division of labor and male–female dichotomy; thus, these algae are ideal model organisms for addressing fundamental issues related to the transition to multicellularity and for discovering universal rules that characterize this transition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The lethality caused by the combination mifepristone/LY294004 in 2-dimensional cell cultures was recapitulated in organized, 3-dimensional spheroids. This study demonstrates that mifepristone and LY294002 when used individually cause cell growth arrest; yet, when combined, they cause lethality.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These cells form tumour spheroids which invade the surrounding matrix, away from the hypoxic conditions in the core of the construct, measured using real time O(2) probes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Most recently, single polyploid tumour cells were shown capable of forming spheroids, releasing EMT-like descendents and inducing tumours in vivo. …”
Enlace del recurso
Enlace del recurso

“…We derived a series of, to our knowledge, new analytic expressions for the characteristic features of the impedance spectra of suspensions of homogeneous and single-shell spherical, spheroidal, and ellipsoidal objects, e.g., biological cells of the general ellipsoidal shape. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An alternative format is a microarray consisting of three-dimensional cell constructs ranging from cell spheroids to cells encapsulated in hydrogel. These systems provide an in vivo-like microenvironment and are preferably used for the investigation of cellular physiology, cytotoxicity, and drug screening. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The high yield strength of 670 MPa, tensile-stress of 740 MPa, and good ductility (elongation of 26%) were obtained by adopting spheroidization annealing, cold rolling, recrystallization annealing, and cold drawing. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso