“…Increasing the SiC content in the charge also caused a change in the solidification nature of the alloy and the mechanism of growth of spheroidal graphite precipitates, causing their surface to form a scaly shell. …”
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“…As the deformation temperature increases and the strain rate decreases, the α phase content gradually decreases in the α + β phase region. Meanwhile, spheroidization and precipitation of α phase are prone to occur in the α + β phase region. …”
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“…A special attention to the emerging technologies for the development of human 3D disease-relevant and physiological models, varying from cell self-assembly (i.e., multicellular spheroids and organoids) to the use of biomaterials and microfluidic devices has been given.…”
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“…In vitro, 3D models of spheroids or organoids can recapitulate spontaneous O(2) gradients in solid tumors. …”
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“…The designed Ni(OH)(2)@CNT contains transition metal cations and interlayer anions, featuring the unique 3D spheroidal flower structure, decent porosity, and large surface area, which is highly conducive to conversion systems and electrochemical energy storage. …”
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“…First, the irregular and dense primary EPL particles were transformed into loose, hollow, and spheroidal particles via co-spray drying with NH(4)HCO(3). …”
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“…Some limitations of 2D preclinical models of the human brain have been overcome by the use of 3D cultures such as cell spheroids, organoids and organs-on-chip. However, one of the most promising approaches for mimicking not only cell structure, but also brain architecture, is currently represented by tissue-engineered brain models. …”
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“…We implemented a novel representation of brain neuropil in silico as a space filled with randomly scattered, overlapping spheres (spheroids) of distributed size. The parameters of perisynaptic space, astroglial presence, and glutamate transport were constrained by the empirical data obtained for the ‘average’ environment of common cortical synapses. …”
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“…Our results demonstrate that 3T3 fibroblasts, HepG2 cells, MB-231 cells and tumor spheroids can be well-maintained for more than 48 h on top of the microscope stage and show physical characters (e.g., morphology and mobility) and growth rate on par with the commercial stage-top incubator and the widely adopted CO(2) incubator. …”
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“…The formation of delta ferrite and a more pronounced degree of spheroidization of the pores is activated by a higher sintering temperature. …”
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“…Compared with two-dimensional (2D) culture, the clinical and biological relevance of three-dimensional (3D) cell spheroids were greater because of their higher regeneration potential since they behave more like cells in vivo. …”
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“…METHODS: We analyzed transcriptomic profile of NSCLC lung adenocarcinoma cohort of TCGA (The Cancer Genome Atlas), stratifying tumors based on EMT (Epithelial mesenchymal Transition) score; in parallel, we investigated the activation of Ido-1 pathway and modulation of immune cytokines productions both in NSCLC cells lines, in peripheral blood mononuclear cells (PBMCs) and in ex-vivo NSCLC spheroids induced by triple inhibition with an anti-PD-L1 monoclonal antibody, the MEK inhibitor and the Ido-1 inhibitor. …”
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“…Observed increases in spheroidal carbonaceous particles (SCPs) in varved lake sediment dating to the early 1950s record rapidly expanding steel production without emission controls around 30 km upwind of the lake. …”
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“…We demonstrate attenuation of hypoxia signaling in populations of stem cells, cancer cells, endothelial cells, cancer spheroids, and intestinal organoids. Varying capsule placement, media formulation, and timing of replenishment yields tunable oxygen gradients, with concurrent spatial growth and morphogenesis in a single well. …”
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“…The promising antiproliferative activity of selected Os(II) complexes was also confirmed using 3D multicellular tumor spheroids, which have the characteristics of solid tumors and can mimic the tumor tissue microenvironment. …”
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“…As a result, the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.…”
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“…After reversion, the cells spontaneously formed spheroids and expressed keratocan and lumican markers, but not mesenchymal ones. …”
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“…Importantly, depletion of KIF16B in primary macrophages also reduces the co-invasion of cancer cells from tumor spheroids, pointing to the KIF16B-driven recycling pathway in macrophages as an important regulatory element of the tumor microenvironment.…”
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“…Subsequent inhibition of METTL3 using a novel small molecule inhibitor, STM2457, significantly impeded tumor growth in LIHC cell lines, spheroids, and xenograft tumor model. Further, transcriptome and m(6)A sequencing of xenograft bodies unveiled that inhibition of METTL3-m(6)A altered genes enriched in SMAD and MAPK signaling pathways that are critical for tumorigenesis. …”
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“…The rodlets consist of bundles of ∼70 ± 10 A proteinaceous filaments closely associated with ∼0.4–0.8 µ spheroidal, granulofibrillar (gf) bodies of a related nature. …”
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