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  1. 4841
    “…After initial growth into spheroids, they remained arrested at a small size comparable to prevascular iris implants, for periods as long as 6 wk. …”
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    TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION
  2. 4842
    “…Within a few hours, MSC migrated into spheroids consisting of pancreatic cancer cells, fibroblasts and endothelial cells as measured by time-lapse microscopy. …”
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    VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
  3. 4843
    “…Moreover, ovarian serous adenocarcinomas were disaggregated and subjected to growth conditions to select for self-renewing, non-adherent spheroids previously shown to be derived from tissue stem cells. …”
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    Ovarian cancer: emerging concept on cancer stem cells
  4. 4844
    “…Previously, we have shown that CG induces the formation of E-cadherin-mediated multicellular spheroids of human breast cancer MCF-7 cells; however, the molecular mechanisms involved in this process are unknown. …”
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    Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation
  5. 4845
    “…Importantly, EGS-induced FLK-1(+) hemangioblasts, when codelivered with mesenchymal stem cells as spheroids, were protected from apoptosis and generated functional endothelial cells and SMCs in ischemic mouse hindlimbs, resulting in improved blood perfusion and limb salvage. …”
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    Enhanced Hemangioblast Generation and Improved Vascular Repair and Regeneration from Embryonic Stem Cells by Defined Transcription Factors
  6. 4846
    por Velasco-Tapia, Fernando
    Publicado 2014
    “…In this locality, the volcanic activity (3.7 to 0.5 Ma) was dominantly dacitic, but the presence of spheroidal andesitic enclaves and/or diverse disequilibrium features in majority of lavas confirms the operation of magma mixing/mingling. …”
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    Multivariate Analysis, Mass Balance Techniques, and Statistical Tests as Tools in Igneous Petrology: Application to the Sierra de las Cruces Volcanic Range (Mexican Volcanic Belt)
  7. 4847
    “…Progress has been made in bone tissue engineering using the RWV, and multicellular tumor spheroids (MCTS), formed in both r- and s-µg, have been reported and were analyzed in depth. …”
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    The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells
  8. 4848
    “…These cells, designated as MEi (mesenchymal stem cell-like mucoepidermoid tumor) cells, could be differentiated towards mesenchymal lineages both with and without induction, and formed spheroids in vitro. The MEi cells shared several multipotent characteristics with BM-MSCs. …”
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    Characterization of Stem-Like Cells in Mucoepidermoid Tracheal Paediatric Tumor
  9. 4849
    por Ai, Zhichao, Jing, Wei, Fang, Li
    Publicado 2016
    “…Our findings demonstrated that Cytl1 is an ovarian hormone-dependent protein expressed in the endometrium that enhances the proliferation of HEC-1-A and RL95-2 cells, stimulates endometrial secretion of LIF and HB-EGF, and enhances the adhesion of HEC-1-A and RL95-2 cells to JAR spheroids. This study suggests that Cytl1 plays an active role in the regulation of embryo implantation.…”
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    Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation
  10. 4850
    “…Of great interest is the use of so-called microtissues or spheroids, which have evolved from their traditional role as in vitro models to their novel role as therapeutic agents. …”
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    Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment
  11. 4851
    “…The approaches for maintaining hepatocytes in vitro are aimed at recapitulating aspects of the native liver microenvironment through the use of co-cultures, surface coatings and 3D spheroids. This study highlights the effects of spatial confinement-a less studied component of the in vivo microenvironment. …”
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    Cell biology is different in small volumes: endogenous signals shape phenotype of primary hepatocytes cultured in microfluidic channels
  12. 4852
    “…Large aggregates of polyubiquitinated proinsulin accumulated in the cytoplasmic vicinity of a unique large spheroidal ERGIC, designated the LUb-ERGIC. Well-known components of ER-associated degradation (ERAD) also accumulated at the LUb-ERGIC, creating a suitable site for ERAD-mediated protein quality control. …”
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    Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells
  13. 4853
    “…It was found that the CA IX-TPL-Lips significantly improved the cellular uptake efficiency in both CA IX-positive human non-small cell lung cancer cells (A549) and A549 tumor spheroids, resulting in the efficient cell killing compared with free TPL and non-targeted TPL-Lips. …”
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    Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
  14. 4854
    “…However, the microstructure of the PTF composite, similar to that of the PTF alloy, consists of near-spheroidal primary particles and intergranular secondarily solidified structures except SiC(p), which are distributed in the secondarily solidified structures. …”
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    A Comparative Study on Permanent Mold Cast and Powder Thixoforming 6061 Aluminum Alloy and Sic(p)/6061Al Composite: Microstructures and Mechanical Properties
  15. 4855
    “…The microtissues with re-associated cells in spheroids are potentially useful as a cell model for pharmacological studies.…”
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    In Vitro Growth of Human Keratinocytes and Oral Cancer Cells into Microtissues: An Aerosol-Based Microencapsulation Technique
  16. 4856
    “…We designed a tooling and methodology to metabolically profile and compare 2D cultures with cancer cell spheroids, and microtissue slices from tumors, and normal organs. …”
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    Metabolic Profiling of healthy and cancerous tissues in 2D and 3D
  17. 4857
    por Taira, Risa, Yumura, Shigehiko
    Publicado 2017
    “…These results shed light on a poorly characterized mechanism of cytokinesis in multicellular spheroids or tissues. We propose to redefine and classify multiple modes of cytokinesis.…”
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    A novel mode of cytokinesis without cell-substratum adhesion
  18. 4858
    “…As a proof‐of‐concept, we mapped twelve epitopes in 3D‐cultured spheroids and investigated the network effects of twelve mitotic cancer drugs. …”
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    Unraveling mitotic protein networks by 3D multiplexed epitope drug screening
  19. 4859
    “…When PDAC cells were cultured on a micro/nanoplate overnight, the cells self-organised into non-spheroidal microtumours that were anchored to the micro/nanoplate through cell-in-cell invasion. …”
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    Visualising the dynamics of live pancreatic microtumours self-organised through cell-in-cell invasion
  20. 4860
    “…Here, we aimed to further decipher the influence of macrophages on breast tumor cells and determined global gene expression changes in three-dimensional tumor spheroids upon infiltration of macrophages. While various tumor-associated mRNAs were upregulated, expression of the cytochrome P450 family member CYP1A1 was markedly attenuated. …”
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    Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation
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