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  1. 4961
    “…This nanoemulsion also produced a 3.3-fold reduction in the viability of MDA-MB-231 spheroids. Elacridar incorporated in the nanoemulsion was capable of inhibiting P-glycoprotein in membranes. …”
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    Phosphatidylcholine-Based Nanoemulsions for Paclitaxel and a P-Glycoprotein Inhibitor Delivery and Breast Cancer Intraductal Treatment
  2. 4962
    por Nazish, Moona, Althobaiti, Ashwaq T.
    Publicado 2022
    “…The pollen shape of all studied species was sub-spheroidal, and exine ornamentation includes microechinate-areolate (11 spp.) and microechinate (1 spp.). …”
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    Palyno-Morphological Characteristics as a Systematic Approach in the Identification of Halophytic Poaceae Species from a Saline Environment
  3. 4963
    “…The development of more complex, predictive, in vitro respiratory models, including two- and three-dimensional cell cultures, spheroids, organoids and tissue cultures, along with more realistic aerosol exposure systems, offers new opportunities to investigate the cytotoxic effects of airborne particulates under controlled laboratory conditions. …”
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    Uncovering the cytotoxic effects of air pollution with multi-modal imaging of in vitro respiratory models
  4. 4964
    “…Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids. The 3D phenotype is infrequent, however, and mechanisms for its incomplete penetrance have been elusive. …”
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    Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state
  5. 4965
    “…Of note, we characterized the set in relevant human primary models by employing hepatotoxicity screening in primary human liver spheroids and viability screening in patient-derived colorectal cancer organoids and matched normal-adjacent epithelium. …”
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    Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum
  6. 4966
    “…Finally, we used the endothelialized liver lobule-like constructs for anti-cancer drug (Sorafenib) screening, and stronger drug resistance results were obtained when compared to either mono-cultured constructs or hepatocyte spheroids alone. The 3D liver cancer models presented here successfully recreate liver lobule-like morphology, and may have the potential to serve as a liver tumor-scale drug screening platform.…”
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    3D Bioprinting of an Endothelialized Liver Lobule-like Construct as a Tumor-Scale Drug Screening Platform
  7. 4967
    “…Microstructural characterization shows no appreciable modifications in the morphology and dimensions of the hard Si-rich phase of the eutectic network and secondary spheroidal Si phase. However, overaging phenomena induced by DLC coating deposition and differences in elastic-plastic properties between the multilayer coating and the PBF-LB AlSi10Mg substrate lead to a reduction in tensile strength by up to 31% and a significant decrease in ductility by up to 58%. …”
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    Influence of Electroless Nickel—DLC (Diamond-like Carbon) Multilayer Coating on the Mechanical Performance of the Heat-Treated AlSi10Mg Alloy Produced by Powder Bed Fusion-Laser Beam
  8. 4968
    “…These CTCs are distinguished by the spontaneous formation of large spheroids, termed tumorospheres, in regular tissue culture. …”
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    Changes of protein expression during tumorosphere formation of small cell lung cancer circulating tumor cells
  9. 4969
    “…Dental pulp-mesenchymal stem cells (DP-MSC) could provide a promising alternative to repair bone defects, principally due to their multipotency and capacity to fabricate three-dimensional (3D) spheroids. The present study aimed to characterize the 3D DP-MSC microsphere and the osteogenic differentiation capacity potential cultured by a magnetic levitation system. …”
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    In Vitro Bone Differentiation of 3D Microsphere from Dental Pulp-Mesenchymal Stem Cells
  10. 4970
    “…Varve couplets of organic matter capped by calcite precipitated each summer in alkaline surface waters reflect environmental change at global to local scales. Spheroidal carbonaceous particles and nitrogen isotopes record an increase in fossil fuel combustion in the early 1950s, coinciding with early fallout from nuclear and thermonuclear testing – (239+240)Pu and (14)C:(12)C, the latter more than compensating for the effects of old carbon in this dolomitic basin. …”
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    The varved succession of Crawford Lake, Milton, Ontario, Canada as a candidate Global boundary Stratotype Section and Point for the Anthropocene series
  11. 4971
    “…Herein, we review both in vitro (cell lines, spheroids, and organoids) and in vivo (xenograft and genetically engineered mouse) models. …”
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    Preclinical Models of Adrenocortical Cancer
  12. 4972
    “…C6-bearing Wistar rats and U87MG-spheroids- and patient-derived glioma stem-like cells-bearing athymic rats underwent tumor resection followed by the implantation of an exemplary LDDS. …”
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    Establishment of a Rodent Glioblastoma Partial Resection Model for Chemotherapy by Local Drug Carriers—Sharing Experience
  13. 4973
    “…Mutations in this gene cause hereditary diffuse leukoencephalopathy with spheroids (HDLS) with autosomal dominant inheritance and BANDDOS (Brain Abnormalities, Neurodegeneration, and Dysosteosclerosis) with autosomal recessive inheritance. …”
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    Homozygous mutation in CSF1R causes brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS)
  14. 4974
    “…METHODS: Here, we constructed an astrocytic scar enclosing GBM in a human assembloid and a mouse xenograft model. GBM spheroids were preformed and then co-cultured with microglia and astrocytes in 3D Matrigel. …”
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    Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid
  15. 4975
    “…Therefore, we demonstrate the action of these diet-derived compounds in suppressing the growth of 3D ovarian cancer spheroids or organoids as well as post-treatment cancer recovery through proliferation, migration, invasion, and colony formation assays when compared to the synthetic epigenetic compound Panobinostat with or without standard chemotherapy. …”
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    The Effects of Natural Epigenetic Therapies in 3D Ovarian Cancer and Patient-Derived Tumor Explants: New Avenues in Regulating the Cancer Secretome
  16. 4976
    “…Trans‐well chamber and multicellular tumor spheroids experiments demonstrate the deep penetration and high accumulation of GC6@cPt nanomotors. …”
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    Self‐Propelled Enzymatic Nanomotors from Prodrug‐Skeletal Zeolitic Imidazolate Frameworks for Boosting Multimodel Cancer Therapy Efficiency
  17. 4977
    “…In the last two decades, new in-vitro models have been developed and improved, including tridimensional-culture spheroids and organoids. However, animal studies remain mandatory in the upscaling before clinical studies. …”
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    Pancreatic cancer orthotopic graft in a murine model
  18. 4978
    “…NPC1 increase facilitates extracellular cholesterol uptake and is necessary for the invasion of ErbB2 expressing breast cancer spheroids and ovarian cancer organoids, indicating a regulatory role for NPC1 in the process. …”
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    Activation of invasion by oncogenic reprogramming of cholesterol metabolism via increased NPC1 expression and macropinocytosis
  19. 4979
    “…We here utilise time‐lapse imaging of HGSOC spheroids coupled to a machine learning approach to classify the phenotype of PTEN loss. …”
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    PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer
  20. 4980
    “…Stemness was measured by spheroids formation assay. Serum exosomes were isolated for circ_0001610 quantification. …”
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    Exosomal transfer leads to chemoresistance through oxidative phosphorylation-mediated stemness phenotype in colorectal cancer
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