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  1. 5121
    “…[Image: see text] Black carbon (BC), spheroidal carbonaceous particles (SCP), and polycyclic aromatic hydrocarbons (PAH) are carbonaceous pollutants affecting the climate, environment, and human health. …”
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    Recent Increased Loading of Carbonaceous Pollution from Biomass Burning in the Baltic Sea
  2. 5122
    “…DR5-B-iRGD penetrated into U-87 tumor spheroids faster than DR5-B and demonstrated an enhanced antitumor effect in human glioblastoma cell lines T98G and U-87, as well as in primary patient-derived glioblastoma neurospheres in vitro. …”
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    DR5-Selective TRAIL Variant DR5-B Functionalized with Tumor-Penetrating iRGD Peptide for Enhanced Antitumor Activity against Glioblastoma
  3. 5123
    “…Austempered ductile iron (ADI), ductile iron (DI), and gray cast iron (GCI), known as spheroidal cast irons, are viable alternative materials compared to traditional steel casting, as well as aluminum casting. …”
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    A Review on Heat Treatment of Cast Iron: Phase Evolution and Mechanical Characterization
  4. 5124
    “…At the protein level, RasGRP1 overexpression significantly inhibits the tumour-promoting effect of IL-6 in hepatocellular carcinoma progenitor cell-like spheroids. Examination of the EGFR signalling pathway shows that RasGRP1 inhibits inflammation-associated cancer cell growth by disrupting the EGFR-SOS1-Ras-AKT signalling pathway. …”
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    RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth
  5. 5125
    “…C9 displayed potent anti-YFV activity in primary human macrophages, 3D hepatocyte spheroids, and in mice. In an A129 murine model, shortly after infection, C9 significantly reduced YFV replication and protected against YFV-induced liver inflammation and pathology with no adverse effects. …”
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    Discovery of a 2′-Fluoro,2′-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice
  6. 5126
    “…Here, we present a stamping magnetoelectric microscale biorobot (SMMB) consisting of neuron-like cell spheroids loaded with magnetoelectric nanoparticles. …”
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    Multi-target cell therapy using a magnetoelectric microscale biorobot for targeted delivery and selective differentiation of SH-SY5Y cells via magnetically driven cell stamping
  7. 5127
    “…We found that pharmacological and genetic inhibition of 11βHSD1 resulted in reprogramming of hepatic stellate cell (HSC) activation via inhibition of p-SMAD3, α-SMA, Snail, and Col1A1 in a fibrotic environment and in multicellular hepatic spheroids (MCHSs). We also determined that 11βHSD1 contributes to the maintenance of NF-κB signaling through modulation of TNF, TLR7, ITGB3, and TWIST, as well as regulating PPARα signaling and extracellular matrix accumulation in activated HSCs during advanced fibrogenesis in MCHSs. …”
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    Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH
  8. 5128
    “…On‐chip coculture experiments of organotypic primary human liver spheroids and intact primary human islets demonstrate insulin secretion and hepatic insulin response dynamics at physiological timescales upon glucose challenge. …”
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    Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia
  9. 5129
    “…The aim of this project was to assess human risk to the exposure of two main regulated mycotoxins (ochratoxin A and fumonisin B1) using different innovative cellular models (2D and 3D spheroids). In this framework, these mycotoxins were tested individually and as a combination on intestinal and hepatic cell lines alone or in co‐cultures. …”
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    Innovative in vitro approaches to toxicological investigations of mycotoxins effects
  10. 5130
    “…Finally, the molecular properties of these tumors are harnessed to assess the therapeutic potential of trastuzumab, a human epidermal growth factor receptor 2 (HER2) inhibitor with growing interest in EC, using patient‐derived organotypic multicellular tumor spheroids and in vivo experiments.…”
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    Generation and Integrated Analysis of Advanced Patient‐Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer
  11. 5131
    “…Moreover, hyperglycaemia caused more pronounced changes in 3D cultures than in 2D cultures, including bigger and a greater number of spheroids, upregulation of NOX4 and the apoptotic proteins NF-κB and CASP3, and downregulation of fibronectin and transglutaminase-2. …”
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    Effects of High Glucose on Human Endothelial Cells Exposed to Simulated Microgravity
  12. 5132
    “…However, more physiological 3D in vitro culture models, such as spheroids and organoids derived from induced pluripotent stem cells (iPSCs), could serve as promising alternatives. …”
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    Induced Pluripotent Stem Cell-Derived Organoids: Their Implication in COVID-19 Modeling
  13. 5133
    “…The dual drug-loaded cyclodextrin nanoplexes diffused deeper into the spheroids and accelerated apoptosis when compared with 5-FU solutions. …”
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    Synergistic Antitumor Potency of a Self-Assembling Cyclodextrin Nanoplex for the Co-Delivery of 5-Fluorouracil and Interleukin-2 in the Treatment of Colorectal Cancer
  14. 5134
    “…Finally, combination treatments trigger apoptosis of cancer cell spheroids. Together, co-targeting of P-TEFb and suppressors of intrinsic apoptosis could become a viable strategy to eliminate cancer cells.…”
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    P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway
  15. 5135
    “…Limonene-based microemulsion was of 133.7 ± 0.513 nm diametric size with unimodal size distribution and spheroidal shape. The nanogel showed ideal characteristics with good mucoadhesive properties and in vitro controlled release with 1.43-fold enhancement in ex vivo nasal permeability compared with the control gel. …”
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    Propranolol-Loaded Limonene-Based Microemulsion Thermo-Responsive Mucoadhesive Nasal Nanogel: Design, In Vitro Assessment, Ex Vivo Permeation, and Brain Biodistribution
  16. 5136
    “…On the PLGA fabric, hADSC re-assembled to form spheroidal-like structures, preserving cell viability and favoring a nonlinear actin organization. …”
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    Microstructured Polymeric Fabrics Modulating the Paracrine Activity of Adipose-Derived Stem Cells
  17. 5137
    “…Although technical limitations have hampered the use of microsampling in these fields, innovative techniques such as 3-D dried blood spheroids, volumetric absorptive microsampling (VAMS), dried plasma spots (DPS), and various microfluidic devices (MDS) can now offer reliable alternatives to traditional samples. …”
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    Biological Fluid Microsampling for Therapeutic Drug Monitoring: A Narrative Review
  18. 5138
    “…The density of low-angle boundaries increases three times: from 0.38 µm(−1) to 1.21 µm(−1) after RS. The process of spheroidization of the lamellar (a + b) component is incomplete. …”
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    Microstructure of the Advanced Titanium Alloy VT8M-1 Subjected to Rotary Swaging
  19. 5139
    “…The crystallite sizes of ZnO spheroidal and hexagonal particles were found to be ranging from 5 to 20 nm while ZnO nanorods were seen to be 5–20 nm wide and 20–40 nm long. …”
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    Sensing Characteristics of Flame-Spray-Made Pt/ZnO Thick Films as H(2) Gas Sensor
  20. 5140
    “…The primary particles evolved into compact spheroidal forms with fractally rough surfaces, while the secondary particles were relatively open mass fractal structures. …”
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    Resolving Early Stages of Homogeneous Iron(III) Oxyhydroxide Formation from Iron(III) Nitrate Solutions at pH 3 Using Time-Resolved SAXS
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