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  1. 5161
    “…DLD-1 (human colon adenocarcinoma) spheroids were used as living target tissue samples. …”
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    Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues
  2. 5162
    “…Ex vitro stability studies by SDS-PAGE as well as in vitro with melanoma A375 revealed a stabilizing effect of D-amino acids in the presence of serum, which was also confirmed in 2D and 3D in vitro experiments on glioblastoma LN-229. 9D-RDP215 was additionally able to pass a BBB model, whereupon it induced significant levels of cell death in LN-229 spheroids. Summarized, the study encourages the introduction of D-amino acids in the design of antitumor peptides for the improvement of their stable antitumor activity.…”
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    Effect of L- to D-Amino Acid Substitution on Stability and Activity of Antitumor Peptide RDP215 against Human Melanoma and Glioblastoma
  3. 5163
    “…We demonstrated that CPPs PepFect6 and NickFect70 are highly effective in transfecting cell lines, primary cell cultures, and three-dimensional spheroids. CPP nanoparticles are capable of inducing siRNA-specific knockdown of therapeutic genes, ribonucleotide reductase subunit M2 (RRM2), and vascular endothelial growth factor (VEGF), which results in the reduction of in vitro cellular proliferation, invasion, and migration. …”
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    Cell-Penetrating Peptide and siRNA-Mediated Therapeutic Effects on Endometriosis and Cancer In Vitro Models
  4. 5164
    “…Therefore, 3D models in CRC PDT, particularly multicellular tumour spheroids (MCTS), have attracted researchers. This review summarizes several photosensitizers that are currently used in CRC PDT and gives an overview of recent advances in nanoparticle application for enhanced CRC PDT. …”
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    Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
  5. 5165
    “…Furthermore, the anticancer efficacy of these drugs was demonstrated in 3D multicellular tumor spheroids (MCTSs) of A549R cells in vitro and in tumor-bearing nude mice in vivo. …”
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    Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens
  6. 5166
    “…Compared with no addition of Pr(6)O(11), adding 1%Pr(6)O(11) resulted in refined, spheroidized and dispersed inclusions in the deposited metal, leading to an increase in the pinning forces on the grain boundary movement, promoting the formation of an ultra-fine grain structure with an average diameter of 41 μm. …”
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    In Situ Observation of Microstructural and Inclusions Evolution in High-Strength Steel Deposited Metals with Various Rare Earth Pr Contents
  7. 5167
    “…Toward this goal, we first developed a simple, rapid, low-cost, and high-throughput method for generating uniform multi-cellular tumor spheroids (MCTS) with controllable size. Next, biomimetic cryogel scaffolds fabricated from hyaluronic acid (HA) were utilized as a platform to reconstruct breast tumor microtissues with aspects of the complex tumor microenvironment in three dimensions. …”
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    Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction
  8. 5168
    “…This culture method can be easily replicated to produce other types of cell co-culture spheroids. The w/w Pickering emulsion template can facilitate the fabrication of 3D co-culture models to a great extent and be further utilized in drug testing and tissue engineering applications.…”
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    Vascularized Co-Culture Clusteroids of Primary Endothelial and Hep-G2 Cells Based on Aqueous Two-Phase Pickering Emulsions
  9. 5169
    “…Epicortical intravital epi-illumination fluorescence video microscopy of the tumor cell spheroids was used to characterize the neovascular architecture and hemodynamics. …”
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    LPPR5 Expression in Glioma Affects Growth, Vascular Architecture, and Sunitinib Resistance
  10. 5170
    por Gupta, Ruby, Sharma, Deepika
    Publicado 2021
    “…In this review, various forms of 3D cultures have been considered and the successful implication of MHCT on them has been summarized, which includes tumor spheroids, and cultures grown in scaffolds, cell culture inserts and microfluidic devices. …”
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    Therapeutic response differences between 2D and 3D tumor models of magnetic hyperthermia
  11. 5171
    “…Novel bioinks in use consist of different types of natural and synthetic polymers, decellularized extracellular matrix and spheroids with encapsulated mesenchymal stem cells, and have shown promising results for periodontal ligament, dentin, dental pulp and bone regeneration application. …”
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    Current Advances of Three-Dimensional Bioprinting Application in Dentistry: A Scoping Review
  12. 5172
    “…Mutations in the CSF1R gene are the most common cause of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a neurodegenerative disease with rapid progression and ominous prognosis. …”
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    Hematopoietic Stem Cell Transplantation in CSF1R-Related Leukoencephalopathy: Retrospective Study on Predictors of Outcomes
  13. 5173
    “…Based on experiment and analysis, the effects of 24 years of exposure on the sigma phase are spheroidization and Cr depletion, and even partial transformation to ferrite. …”
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    The study of sigma and carbide in cast austenitic stainless-steel grade HH after 24 years of high-temperature service
  14. 5174
    “…A total of three HNSCC cell lines (Sa3, HSC2 and HSC4) were used to investigate the characteristics of LAT1-positive cells, including their ability to form spheroids, and their invasion and migration. The present study also examined LAT1 by immunostaining of biopsy specimens from 174 patients diagnosed, treated and followed-up at Akita University (Akita, Japan) between January 2010 and December 2019, and overall survival, progression-free survival and multivariate analyses were performed. …”
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    LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma
  15. 5175
    “…In addition, T-cell cytotoxic activity against 3-dimensional tumor spheroids was measured. Our data demonstrated that CD4(+) T cells coexpressing the TCR and CD8α coreceptor displayed enhanced responses, including CD40 ligand expression, interferon-gamma secretion, and cytotoxic activity, along with improved dendritic cell activation. …”
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    Enhancing Efficacy of TCR-engineered CD4(+) T Cells Via Coexpression of CD8α
  16. 5176
    “…CYT-303 was highly potent and effective in mediating NK cell-redirected cytotoxicity against multiple HCC tumor cell lines and tumor spheroids. More interestingly, it can reverse the dysfunction induced in NK cells following repeated rounds of serial killing of tumors. …”
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    Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3
  17. 5177
    “…Finally, we verified that ME reduced the growth of three-dimensional (3D) pancreatic cancer spheroids. Our study demonstrates that ME suppresses pancreatic cancer proliferation through the IGFBP3-PI3K-mTOR signaling pathway. …”
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    Mychonastes sp. 246 Suppresses Human Pancreatic Cancer Cell Growth via IGFBP3-PI3K-mTOR Signaling
  18. 5178
    “…To address this need, we developed a 3D co-culture system termed iAssembloids (induced multi-lineage assembloids) that enables the rapid generation of homogenous neuron-glia spheroids. We characterize these iAssembloids with immunohistochemistry and single-cell transcriptomics and combine them with large-scale CRISPRi-based screens. …”
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    CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
  19. 5179
    “…Morphological study was carried out on a Transmission Electron Microscope (TEM), and the results indicated that the two polymers had irregular spheroidal structure with some pores distributed on their surface. …”
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    Amino acid modified OCMC-g-Suc-β-CD nanohydrogels carrying lapatinib and ginsenoside Rg1 exhibit high anticancer activity in a zebrafish model
  20. 5180
    “…To achieve significantly longer exposure times, we used a spheroidal model system of castration-resistant prostate cancer. …”
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    Extended Exposure Topotecan Significantly Improves Long-Term Drug Sensitivity by Decreasing Malignant Cell Heterogeneity and by Preventing Epithelial–Mesenchymal Transition
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