“…Primary acinar cells can survive in vitro as organoid-like 3D spheroids, which can transdifferentiate into cells with a clear ductal morphology in response to different cell- and non-cell-autonomous stimuli. …”
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“…Probe CS-1 can selectively label cancer cells and 3D cancer spheroids and be readily observed using the green fluorescence channel (λ(em) = 532 nm). …”
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“…The results showed that when the oxidation temperature was 800 °C, the spheroidization of Fe–10Cr steel occurred, and the oxidation kinetics conformed to the linear law. …”
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“…In SH-SY5Y cell monolayers and spheroids the exposure to NT-3 enhanced the apoptotic cascade triggered by VPA. …”
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“…The MBGNPs exhibited spheroidal morphology and disordered mesoporous structure. …”
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“…The anticancer activity of prepared nanomicelles and pure PTX were evaluated by 2D cytotoxicity assay against breast cancer cell line MDA-MB-231 and in the real tumour environments i.e. 3D tumor spheroids of MDA-MB-231 cells. The highest cytotoxicity effect of PTX was observed with F68-CAA-PTX nanomicelles followed by F68-SA-PTX and free PTX. …”
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“…Scaffolds with small pores (73 ± 25 μm) promoted larger PHH spheroids and consequently higher PHH functions than large pores (235 ± 84 μm) for at least 1 month in culture. …”
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“…Finally, grain coarsening destroyed the spheroidal particle shape after heating to 800 °C. In striking contrast, SiO(2)-encapsulation significantly inhibited grain growth and the t → m transition progressed considerably only after heating to 1000 °C, whereupon the particle shape, with a smooth silica shell, remained stable. …”
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“…A diversity of three-dimensional cancer models, such as spheroids, organoids (organotypic cultures), explants, mouse xenografts, are addressed. …”
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“…The results show that the magnitude of residual stress and the distribution of defects under different process parameters had a strong influence on the microstructure and properties of the scaffold, and the residual stress of the Body-Centered Cube (BCC) structure formed at an energy density of 41.7 J/mm(3) was significantly reduced, with less surface spheroidization and fewer cracks on the melt pool surface. …”
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“…Concave microwells have mostly been used in organ-on-a-chip models, including the formation and culture of 3D cell aggregates (spheroids, organoids, and embryoids). Researchers have also used microwells to study the influence of substrate topology on cellular behaviors. …”
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“…We have expanded this approach to trace the labeled atom fate of [(13)C(6)]-glucose in 3D A549 spheroids in response to the anticancer agent selenite and that of [(13)C(5),(15)N(2)]-glutamine in 2D BEAS-2B cells in response to arsenite transformation. …”
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“…Therefore, we used the targeted inhibitor NCT-501 and found that it could inhibit the proliferation and stem cell spheroidization of NPC cells, and induce necroptosis. …”
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“…Androgen receptors are related to RCC and were predominantly increased in RCC30 cells, which were the only cells that formed nivolumab-dependent spheroids. Finally, all cell lines exhibited a complex response to nivolumab treatment. …”
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“…The vascular barrier, transcellular migration, and tumor spheroids experiments showed that PTX-SM-TAR NPs exhibit great transvascular transport and tumor penetration ability. …”
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“…In this study, the effects of PMC surface modification with the DR5-B ligand on cell uptake both in 2D (monolayer culture) and 3D (tumor spheroids) were studied by confocal microscopy, flow cytometry and fluorimetry. …”
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“…HLC maturation can be significantly improved using advanced techniques, such as protein micropatterning to precisely control cell-cell interactions, controlled sized spheroids, organoids with multiple cell types and layers, 3-dimensional bioprinting to spatially control cell populations, microfluidic devices for automated nutrient exchange and to induce liver zonation via soluble factor gradients, and synthetic biology to genetically modify the HLCs to accelerate and enhance maturation. …”
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“…Everyday experience confirms the tendency of adhesive films to detach from spheroidal regions of rigid substrates—what is a petty frustration when placing a sticky band aid onto a knee is a more serious matter in the coating and painting industries. …”
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“…Patients who underwent DALK for advanced keratoconus, keratoconus with Bowman's membrane scar, healed hydrops, macular corneal opacity, macular corneal dystrophy, granular corneal dystrophy, spheroidal degeneration, pellucid marginal degeneration, post-LASIK ectasia, descemetocele, postcollagen cross-linking aborted melt and dense scar, and postradial keratotomy were included in the study. …”
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“…Such models include melanoma organoids, spheroids, and reconstructed human melanoma‐in‐skin cultures. …”
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