“…Single-cell RNA sequencing data from ATRT-06 spheroids treated with 4SC-202 have a reduced population of cells overexpressing stem cell-related genes, including SOX2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Self-assembled in culture, these structures varied in size, were either compact or hollow, irregular, or spheroidal, and exhibited replicative capacity and an epithelial nature. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Cultivation of ASCs in the chitosan/cartilage ECM composite 3D scaffolds induced the formation of cell spheroids with profound glycosaminoglycan production after 14 and 28 days culture. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In vitro imaging studies confirmed their enzyme-activatable therapy response tracking abilities both in cancer cells and tumor spheroids. Furthermore, SPN treated mice exhibited better tumor growth inhibition as compared to the control groups and therapy response could be imaged at both early (24-48h) and later time points. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, the obtained optimal FSNP-C with OTES-modification can provide hydrophobic repulsive forces to effectively inhibit the π–π stacking interaction of cyanine dyes and simultaneously reduce the formation of strong oxidizing species (•OH and H(2)O(2)) in reaction with H(2)O, resulting in the best photostability (fluorescent intensity remained at 90.1% of the initial value after 300 s of laser scanning) and a high PDT efficiency on two- and three-dimensional (spheroids) HeLa cell culture models. Moreover, through molecular engineering (including increasing covalent anchoring sites and steric hindrance groups of cyanine dyes), FSNP-C exhibits the highest fluorescent intensity both in water solution (12.3-fold improvement compared to free dye) and living cells due to the limitation of molecular motion. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The cause of death among high-grade serous ovarian cancer (HGSOC) patients involves passive dissemination of cancer cells within the peritoneal cavity and subsequent implantation of cancer spheroids into adjacent organs. Sushi Domain Containing 2 (SUSD2) encodes a type I transmembrane protein containing several functional domains inherent to adhesion molecules. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The layered (α-Al + Mg(2)Si) eutectic structure plus a small amount of Al(8)(Fe,Mn)(2)Si phase in the as-cast condition became an in-situ Mg(2)Si particulate-reinforced aluminum composite with spherical Mg(2)Si particles uniformly distributed in the α-Al matrix after heat treatment. Due to the spheroidization of intermetallic phases including both Mg(2)Si and Al(8)(Fe,Mn)(2)Si, the ductility and hardening capacity increased while the yield stress (YS) and ultimate tensile strength (UTS) decreased. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These include multicellular spheroids, organoids, and organs-on-chips, each of which has its own advantages and limitations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…High cytotoxicity of the [(223)Ra]BaFe–CEPA–trastuzumab bioconjugate was confirmed by radiotoxicity studies on SKOV-3 cell monolayers and 3D-spheroids. In addition, the magnetic properties of the radiobioconjugate should allow for its use in guide drug delivery driven by magnetic field gradient.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We observed a tendency to deepen contact minima with an increase in ionic strength value in the case of spherical and spheroidal molecules. Additionally, two-dimensional distribution functions describing water density and average number of hydrogen bonds between water molecules were calculated in both water models for adamantane and hexane. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this work, the abundance of contact proteins was compared in SKOV-3 and SKOV-3.ip human ovarian adenocarcinoma cell lines, cultivated in monolayers, tumor spheroids and collagen hydrogels. Three-dimensional models were characterized by extremely low expression of basic molecules of adherens junctions E-cadherin and demonstrated a simultaneous decrease in desmosomal protein desmoglein-2, gap junction protein connexin-43 and tight junction proteins occludin and ZO-1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It did not reduce the growth of multicellular lung and renal cancer spheroids but reduced the cell viability by the ATP Bioluminescence assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…One construct consisted of 960 spheroids obtained from 3.5 × 10(4) autologous AT-MSCs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using TAK-164, an anti-GCC ADC undergoing clinical evaluation, we show that the lipophilic DNA-alkylating payload, DGN549, penetrates beyond the cell targeted layer in GCC-positive tumor spheroids and primary human tumor xenograft models. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To derive the weight from two-dimensional imagery, we calculated elliptical spheroids from lengths of diameters and heights. The performance of this processes was evaluated by comparison with manually harvested ground-truth samples and cross-checked for misclassification from randomly selected test objects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this review, we discuss the most common 3D culture systems—spheroids, organoids, and microfluidic chips—and detail how these systems have advanced our understanding of cancer immunology.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…SEM examination shows the spheroidal particle morphology of powders, which is typical for this method. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We studied the influence of the matrix-modulating enzymes hyaluronidase and collagenase on the uptake of magnetic nanoparticles by pancreatic cancer cells and 3D spheroids thereof, and the overall impact on magnetic heating and cell death. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…NFLP was also shown to phenocopy the PYCR1 knockdown in MCF10A H-RAS(V12) breast cancer cells by inhibiting de novo proline biosynthesis and impairing spheroidal growth. In summary, we generated the first validated chemical probe of PYCR1 and demonstrated proof-of-concept for screening proline analogs to discover inhibitors of the proline cycle.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The three-dimensional structure of the simulated cough shows that the assumption of a spheroidal puff front fails to capture the observed ellipsoidal shape. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso