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  1. 5501
    “…Moreover, caffeine could attenuate the formation of 3D tumor spheroids in cancer stem cell (CSC)-enriched populations. …”
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    Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin αv, β3, and FAK/Akt/c-Myc Signaling Pathway
  2. 5502
    “…Furthermore, the LVTX-9-C(18) also showed strong cytotoxicity in relation to 3D B16-F10 spheroids, which indicates it might be a promising lead for developing anticancer drugs.…”
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    Fatty Acid Modification of the Anticancer Peptide LVTX-9 to Enhance Its Cytotoxicity against Malignant Melanoma Cells
  3. 5503
    “…In overexpression studies, MCF-7 cells and spheroids stably expressed HA-MOAP-1 and Myc-BCL-XL exhibited differential chemosensitivity toward α-mangostin in which the stable clones expressing HA-MOAP-1 and MYC-BCL-XL were chemosensitive and chemoresistant to the apoptosis signaling events mediated by α-mangostin, respectively, when compared to untreated cells. …”
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    Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells
  4. 5504
    “…PDLFs were either conventionally seeded or embedded into different 3D structures (spheroids, Mebiol(®) gel, 3D scaffolds) and exposed to compressive force or incubated without pressure. …”
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    An Evaluation of Different 3D Cultivation Models on Expression Profiles of Human Periodontal Ligament Fibroblasts with Compressive Strain
  5. 5505
    “…Indeed, they acquired CSC-marker expression, and self-renewal properties, showed by their increased capacity to form spheroids. The miRNome analysis revealed that long-term IL-17 treatment of LPCs led to a 90% decrease in miR-122 expression. …”
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    Interleukin-17 programs liver progenitor cell transformation into cancer stem cells through miR-122 downregulation with increased risk of primary liver cancer initiation
  6. 5506
    “…The aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal differentiation. …”
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    Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors
  7. 5507
    “…The efficacy of SDT with SW and Ala in halting cancer cell proliferation was also confirmed in 3D cancer spheroids. The present study suggests that SW-mediated SDT is a valuable approach to slow down tumour proliferation, thus opening an innovative scenario in cancer treatment.…”
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    Exploiting Shock Waves to Trigger the Anticancer Sonodynamic Activity of 5-Aminolevulinc Acid-Derived Protoporphyrin IX on In Vitro 2D and 3D Cancer Models
  8. 5508
    “…Sprouting assays demonstrated that within Coll/HA scaffolds, HUVECs spheroids formed significantly more and longer sprouts in the presence of IFN-γ conditioned iMSC secretome. …”
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    Pre-Conditioning with IFN-γ and Hypoxia Enhances the Angiogenic Potential of iPSC-Derived MSC Secretome
  9. 5509
    “…Our results showed that tumour spheroids formed in the 3D collagen model displayed good viability and decreased growth rates, which partly recapitulated the growth behavior of in vivo tumour cells. …”
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    Collagen-based three-dimensional culture microenvironment promotes epithelial to mesenchymal transition and drug resistance of human ovarian cancer in vitro
  10. 5510
    “…Under the influence of cellular and non-cellular factors, EOC spheroids use the natural flow of peritoneal fluid to reach distant organs within the peritoneal cavity. …”
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    The Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination
  11. 5511
    “…We first review the latest development in the field by detailing various types of in vitro human cancer models, including transwell-based models, tumor spheroids, microfluidic tumor-microvascular systems and scaffold-based models. …”
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    In Vitro Human Cancer Models for Biomedical Applications
  12. 5512
    “…METHODS: Medulloblastoma cell lines, patient-derived xenograft cells, 3D spheroids and an innovative cerebellar organotypic model were used to identify synergistic interactions between β-blockers and ionising radiations. …”
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    Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma
  13. 5513
    “…The ability to form spheroids under non‐adherent conditions is a well‐known property of human mesenchymal stem cells (hMSCs), in addition to stemness and multilineage differentiation features. …”
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    Phenotypic, morphological, and metabolic characterization of vascular‐spheres from human vascular mesenchymal stem cells
  14. 5514
    “…Results: TNVs were isolated and characterized as nano-size spheroids. The IVIS imaging experiment indicated that orally administrated TNVs could accumulate in the inflamed colon sites and exhibited superior anti-inflammatory activity both in vitro and in vivo. …”
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    Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis
  15. 5515
    “…In this review, we introduce the reader to experimental studies that employ patient-derived material to produce spheroids, organoids, or organs-on-a-chip as platforms that allow a more accurate representation of cancer complexity compared to bidimensional cell cultures. …”
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    Advanced Cellular Models for Preclinical Drug Testing: From 2D Cultures to Organ-on-a-Chip Technology
  16. 5516
    por Miloh, Touvia, Avital, Eldad J.
    Publicado 2022
    “…So far, most of the available electrokinetic theoretical studies involving polarizable nano/micro shapes dealt with convex configurations (e.g., spheres, spheroids, ellipsoids) and as such the newly obtained electrostatic AC solution for a dimer provides a useful extension for similar concave colloids and engineered particles.…”
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    Travelling-Wave Electrophoresis, Electro-Hydrodynamics, Electro-Rotation, and Symmetry-Breaking of a Polarizable Dimer in Non-Uniform Fields
  17. 5517
    “…It also improved the cytotoxicity of HepG2 spheroids 44-folds more than PIT-free solution. RT-PCR analysis showed that LF-coated PIT-loaded bilosomes caused an improvement (2-fold increase) in the apoptotic potential of PIT mediated by caspase-3. …”
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    Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach
  18. 5518
    “…Finally, we analyze the cellular pathways induced by PBM and outcomes observed in various 3D tissue-engineered constructs: hydrogels, scaffolds, spheroids, cell sheets, bioprinted structures, and organoids. …”
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    Photobiomodulation in 3D tissue engineering
  19. 5519
    “…More DNA damage accumulated, and spheroids lost their membrane integrity due to the combinational treatment. …”
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    Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer
  20. 5520
    “…NO-COXIBs were tested in vitro for a combination with single-dose external X-ray irradiation as well as [(177)Lu]LuCl(3) treatment in HIF2α-positive mouse pheochromocytoma (MPC-HIF2a) tumor spheroids. When applied directly before X-ray irradiation or (177)Lu treatment, NO-COXIBs showed radioprotective effects, as did celecoxib, which was used as a control. …”
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    Exploring Nitric Oxide (NO)-Releasing Celecoxib Derivatives as Modulators of Radioresponse in Pheochromocytoma Cells
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