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Mostrando 601 - 620 Resultados de 6,033 Para Buscar '"Spheroid', tiempo de consulta: 0.16s Limitar resultados
  1. 601
    “…A higher number of cells per spheroid correlated with a higher basal metabolic activity in tissue-derived spheroids (p < 0.01), while the opposite was observed for cell line spheroids (p < 0.01). …”
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    Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids
  2. 602
    “…The biological results demonstrate that the ultralow shear dynamic suspension provided by the device is beneficial for culturing cancer cell spheroids. In comparison to the static suspension control, dynamic cell suspension preserves morphological features, promotes intercellular connection, increases spheroid size (2.4-fold increase) and number of cycling cells (1.58-fold increase), and reduces double strand DNA damage (1.5-fold reduction). …”
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    A Versatile Bioreactor for Dynamic Suspension Cell Culture. Application to the Culture of Cancer Cell Spheroids
  3. 603
    por Xu, Yong, Shi, Taoping, Xu, Axiang, Zhang, Lei
    Publicado 2016
    “…In this study, we aimed to investigate the therapeutic effects of 3D spheroids of human adipose‐derived MSCs for acute kidney injury (AKI). …”
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    3D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney
  4. 604
    “…To enable better assessment of cancer immunotherapy agents in vitro, we developed a three-dimensional (3D) heterotypic spheroid model composed of tumor cells, fibroblasts, and immune cells. …”
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    A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents
  5. 605
    “…We applied a spheroid culture system as the selective/inductive step for progenitor cell culture, as described in many biological systems. …”
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    Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties
  6. 606
    “…In this review, current progress in the knowledge of signaling pathways affecting EMT/MET and stemness regulation will be outlined by comparing data obtained from cellular spheroids systems, as ex vivo niches of stem cells derived from normal and tumoral tissues. …”
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    EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids
  7. 607
    “…The MDA-MB-231 embedded spheroid tumor model exhibited the most robust response to chemotherapeutic treatment, and possessed the greatest cancer stem cell (CSC) content. …”
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    Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment
  8. 608
    “…Additionally, described is the use of 3D spheroids in carrying out functional metabolic assays to probe cellular bioenergetics pathways using an extracellular flux analyzer paired with a spheroid microplate. …”
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    Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts
  9. 609
    “…With this, a higher encapsulation efficiency of both drugs and an enhanced cumulative release were achieved. Spheroid study further demonstrated that the controlled release of the drugs from the methyl-β-cyclodextrin -loaded hollow microparticles exhibited enhanced tumor regressions of MCF-7 tumor spheroids. …”
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    Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids
  10. 610
    “…The multicellular tumor spheroid (MCTS) model closely mimics a small avascular tumor with the presence of proliferative cells surrounding quiescent cells and a necrotic core. …”
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    Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
  11. 611
    “…PURPOSE: To determine the prevalence of spheroidal degeneration of cornea (SDC) and its association with other eye diseases in the tribes of South-West Rajasthan. …”
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    Prevalence of spheroidal degeneration of cornea and its association with other eye diseases in tribes of Western Rajasthan
  12. 612
    “…Conversely, the bottom-up approach aims to precondition cells to form modular tissues units (building-blocks) represented by spheroids. In spheroid culture, adult stem cells are responsible for their extracellular matrix synthesis, re-creating structures at the tissue level. …”
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    Adult Stem Cells Spheroids to Optimize Cell Colonization in Scaffolds for Cartilage and Bone Tissue Engineering
  13. 613
    “…Our data support the monophyletic spread of tumor spheroids in malignant ascites.…”
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    Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites
  14. 614
    “…Metastatic ascites contain multicellular spheroids, which promote chemo-resistance and recurrence. …”
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    Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer
  15. 615
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    A multiple-funnels cell culture insert for the scale-up production of uniform cell spheroids
  16. 616
    “…The technology enabled the formation of repeatable drug concentration gradients across an array of spheroids without external fluid actuation, delivering simultaneously a range of drug concentrations to multiple sized spheroids, as well as replicates for each concentration. …”
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    Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient
  17. 617
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    Endogenously Triggerable Ultrasmall-in-Nano Architectures: Targeting Assessment on 3D Pancreatic Carcinoma Spheroids
  18. 618
    “…It was shown, by flow cytometry and confocal microscopy, that the fluorescein-labeled S(20)-SSO was freely diffusing and penetrating the innermost cells of MCTS, whereas the vector-complexed SSO penetrated only the cells of the spheroid’s outer layer.…”
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    Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids
  19. 619
    “…Herein, we report the development of a hydrogel microwell array to generate uniform-sized multicellular tumor spheroids. Our developed multicellular tumor spheroids are structurally well-defined, robust and can be easily transferred into the widely used 2D culture substrates while maintaining our designed multicellular 3D-sphere structures. …”
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    Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
  20. 620
    “…Overexpression of two selected genes, WIPI1 and SLITKR4, induced cellular senescence in in ULM spheroids. Additionally, administration of ABT263 (a BH3 mimetic) effectively reduced the senescent cells induced in ULM spheroids. …”
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    Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
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