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741“…A comprehensive dataset of multielectrode array recordings was collected from three-dimensional hen embryo brain cell cultures, termed spheroids, under long-term electrical stimulation. …”
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742por Leng, Zhengwei, Tao, Kaixiong, Xia, Qinghua, Tan, Jun, Yue, Zhongyi, Chen, Jinhuang, Xi, Hailin, Li, Jie, Zheng, Hai“…The spheroid cells with reduced KLF4 expression also had decreased expression of CSCs markers and mesenchymal markers. …”
Publicado 2013
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743“…Of note, while both treatment combinations killed the same cancer cell lines in 2D culture, skin equivalent-embedded melanoma spheroids are potently killed by TRAIL+cisplatin treatment but remain almost unaffected by the TRAIL+UVB combination. …”
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744por Senavirathna, Lakmini K., Fernando, Ruchika, Maples, Danny, Zheng, Yuanshui, Polf, Jerimy C., Ranjan, Ashish“…Multicellular Tumor Spheroids (MCTS) strongly resemble tumor tissues, which makes them useful tools for radiation biology studies and screening of various chemotherapeutics. …”
Publicado 2013
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745por Han, Xiao-Yan, Wei, Bo, Fang, Jia-Feng, Zhang, Shi, Zhang, Fu-Cheng, Zhang, Hai-Bo, Lan, Tian-Yun, Lu, Hui-Qiong, Wei, Hong-Bo“…The spheroid cells also demonstrated down-regulated E-cadherin and up-regulated α-SMA and Vimentin expression, which is the typical phenotype of EMT. …”
Publicado 2013
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746por Cui, Jie, Guo, Ya-Huan, Zhang, Hong-Yi, Jiang, Li-Li, Ma, Jie-Qun, Wang, Wen-Juan, Wang, Min-Cong, Yang, Cheng-Cheng, Nan, Ke-Jun, Song, Li-Ping“…This study aimed to determine whether celecoxib combined with 5-fluorouracil or sorafenib or gefitinib is beneficial in HepG2 multicellular spheroids (MCSs), as well as elucidate the underlying mechanisms. …”
Publicado 2014
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747por Gotoh, Shimpei, Ito, Isao, Nagasaki, Tadao, Yamamoto, Yuki, Konishi, Satoshi, Korogi, Yohei, Matsumoto, Hisako, Muro, Shigeo, Hirai, Toyohiro, Funato, Michinori, Mae, Shin-Ichi, Toyoda, Taro, Sato-Otsubo, Aiko, Ogawa, Seishi, Osafune, Kenji, Mishima, Michiaki“…Methods to induce and isolate AEPCs using CPM and consequently generate alveolar epithelial spheroids would aid human pulmonary disease modeling and regenerative medicine.…”
Publicado 2014
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748por Yoshida, Takahiro, Okuyama, Hiroaki, Nakayama, Masashi, Endo, Hiroko, Nonomura, Norio, Nishimura, Kazuo, Inoue, Masahiro“…In this study, we utilized cancer tissue-originated spheroids (CTOS) prepared from bladder cancers or patient-derived xenografts, which may recapitulate human tumors better than 2-D cultures of established cell lines. …”
Publicado 2015
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749por Mischiati, Carlo, Ura, Blendi, Roncoroni, Leda, Elli, Luca, Cervellati, Carlo, Squerzanti, Monica, Conte, Dario, Doneda, Luisa, Polverino de Laureto, Patrizia, de Franceschi, Giorgia, Calza, Roberta, Barrero, Carlos A., Merali, Salim, Ferrari, Carlo, Bergamini, Carlo M., Agostinelli, Enzo“…In order to approach the problem of EMT in cholangiocarcinoma, we decided to investigate the changes in protein expression occurring in two cell lines under conditions leading to growth as adherent monolayers or to formation of multicellular tumor spheroids (MCTS), which are considered culture models that better mimic the growth characteristics of in-vivo solid tumors. …”
Publicado 2015
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750“…METHODS: Multicellular SKOV-3 tumor spheroids were developed using the hanging drop method and expression levels of glycolytic markers were examined. …”
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751“…However, tumour cell lines growing as multicellular tumour spheroids (MTS) frequently develop multicellular resistance in a drug-independent form. …”
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752por Vadivelu, Raja K., Ooi, Chin H., Yao, Rebecca-Qing, Tello Velasquez, Johana, Pastrana, Erika, Diaz-Nido, Javier, Lim, Filip, Ekberg, Jenny A. K., Nguyen, Nam-Trung, St John, James A.“…Floating liquid marbles allow the OECs to freely associate and interact to produce OEC spheroids with uniform shapes and sizes. In contrast, a sessile liquid marble on a solid surface suffers from evaporation and the cells aggregate with irregular shapes. …”
Publicado 2015
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753por Freedman, Benjamin S., Brooks, Craig R., Lam, Albert Q., Fu, Hongxia, Morizane, Ryuji, Agrawal, Vishesh, Saad, Abdelaziz F., Li, Michelle K., Hughes, Michael R., Werff, Ryan Vander, Peters, Derek T., Lu, Junjie, Baccei, Anna, Siedlecki, Andrew M., Valerius, M. Todd, Musunuru, Kiran, McNagny, Kelly M., Steinman, Theodore I., Zhou, Jing, Lerou, Paul H., Bonventre, Joseph V.“…In three-dimensional cultures, epiblast-stage hPSCs form spheroids surrounding hollow, amniotic-like cavities. …”
Publicado 2015
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754por MEENACH, SAMANTHA A., TSORAS, ALEXANDRA N., McGARRY, RONALD C., MANSOUR, HEIDI M., HILT, J. ZACH, ANDERSON, KIMBERLY W.“…The MCS were formed by seeding lung cancer cells on top of collagen where they formed spheroids due to the prevalence of cell-to-cell interactions. …”
Publicado 2016
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755por Barbone, Dario, Van Dam, Loes, Follo, Carlo, Jithesh, Puthen V., Zhang, Shu-Dong, Richards, William G., Bueno, Raphael, Fennell, Dean A., Broaddus, V. Courtney“…We asked whether the gene expression of 3D spheroids would reveal mechanisms of resistance. To address this, we measured gene expression of three mesothelioma cell lines, M28, REN and VAMT, grown as 2D monolayers and 3D spheroids. …”
Publicado 2016
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757por Langan, Laura M., Dodd, Nicholas J. F., Owen, Stewart F., Purcell, Wendy M., Jackson, Simon K., Jha, Awadhesh N.Enlace del recurso
Publicado 2016
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758por Murphy, Kaitlin C., Hoch, Allison I., Harvestine, Jenna N., Zhou, Dejie, Leach, J. Kent“…Spheroids were then entrapped in collagen hydrogels, and the osteogenic stimulus was removed. …”
Publicado 2016
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759por Shu, Yaqing, Long, Ling, Liao, Siyuan, Yang, Jiezheng, Li, Jianfang, Qiu, Wei, Yang, Yu, Bao, Jian, Wu, Aiming, Hu, Xueqiang, Lu, Zhengqi“…BACKGROUND: Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare autosomal dominant disorder characterized by cerebral white matter degeneration and caused by mutations in the colony-stimulating factor 1 receptor (CSF1R) gene. …”
Publicado 2016
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760por Otsuka, Hidenori, Sasaki, Kohei, Okimura, Saya, Nagamura, Masako, Nakasone, Yuichi“…Here, we present a novel approach to generate layered patterning of hepatocyte spheroids on micropatterned non-parenchymal feeder cells using microfabricated poly(ethylene glycol) (PEG) hydrogels. …”
Publicado 2013
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