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Mostrando 801 - 820 Resultados de 6,033 Para Buscar '"Spheroid', tiempo de consulta: 0.58s Limitar resultados
  1. 801
    “…Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their three-dimensionality. …”
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    Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing
  2. 802
    “…Three-dimensional culture systems that allow generation of monolayered epithelial cell spheroids are widely used to study epithelial function in vitro. …”
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    Application and Comparison of Supervised Learning Strategies to Classify Polarity of Epithelial Cell Spheroids in 3D Culture
  3. 803
    “…BACKGROUND: A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity. …”
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    Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis
  4. 804
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    Graphene oxide suppresses the growth and malignancy of glioblastoma stem cell-like spheroids via epigenetic mechanisms
  5. 805
    “…Herein, a therapy option is presented that makes use of a heterogeneous population of lung cells, including progenitor cells and supporting cells lines, cultured in adherent and suspension conditions, the latter of which induces spontaneous spheroid formation. Within these spheroids, progenitor marker expression is augmented. …”
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    A pre‐investigational new drug study of lung spheroid cell therapy for treating pulmonary fibrosis
  6. 806
    “…In particular, we found that spheroids, compared to 2D cultures, were generally both more sensitive and showed greater synergistic response to combinations involving a MEK inhibitor. …”
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    High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
  7. 807
    “…To do so, we performed single-cell RNA-seq of MCF7 Multicellular Tumor Spheroids as a tumor model. Analysis of single-cell transcriptomes at two-time points of the spheroid growth, allowed us to dissect their functional relationship. …”
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    Unveiling functional heterogeneity in breast cancer multicellular tumor spheroids through single-cell RNA-seq
  8. 808
    “…Because many cell lines have the ability to self-assemble, one 3D culturing method is to produce spheroids. There are several systems for culturing cells in spheroids, e.g., hanging drop, scaffolds and hydrogels, and these cultures have their applications in drug and nanoparticles testing, and disease modeling. …”
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    Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important Application
  9. 809
    “…Spontaneous activity and spheroid structure were highly consistent from well-to-well, reference compounds such as TTX, 4-AP, AP5, and NBQX, had expected effects on neural spontaneous activity, demonstrating the presence of functionally integrated neuronal circuitry. …”
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    Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids
  10. 810
    “…Use of multicellular spheroids in studies of nanoparticles (NPs) has increased in the last decade, however details of NPs interaction with spheroids are poorly known. …”
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    Ultrastructural Features of Gold Nanoparticles Interaction with HepG2 and HEK293 Cells in Monolayer and Spheroids
  11. 811
    “…We found that 40% of all isolates naturally self-assembled into multicellular spheroids within 24 h in anchorage-free culture, while 60% did not. …”
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    Self-assembling 3D spheroid cultures of human neonatal keratinocytes have enhanced regenerative properties
  12. 812
    por Yeo, Miji, Chae, SooJung, Kim, GeunHyung
    Publicado 2021
    “…A spheroid is an aggregation of single cells with structural and functional characteristics similar to those of 3D native tissues, and it has been utilized as one of the typical in vitro three-dimensional (3D) cell models. …”
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    An in vitro model using spheroids-laden nanofibrous structures for attaining high degree of myoblast alignment and differentiation
  13. 813
    “…Importantly, antigen-specific CD8(+) T cell responses were reduced in the presence of tumour explant-conditioned Mφs, but not spheroid-conditioned Mφs, suggesting explants are likely a more relevant model of the immune TME than cell line-derived spheroids. …”
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    Macrophage Plasticity and Function in the Lung Tumour Microenvironment Revealed in 3D Heterotypic Spheroid and Explant Models
  14. 814
    “…Further, the depth of penetration of 15 nm GNPs over 50 nm GNPs increased by 33% for CAL-27 spheroids and 17% for HeLa spheroids. These results highlight the necessity to optimize GNP treatment conditions in a more realistic tumor-life environment. …”
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    Three-Dimensional Tumor Spheroids as a Tool for Reliable Investigation of Combined Gold Nanoparticle and Docetaxel Treatment
  15. 815
    “…Still, further research and clinical studies with controlled and consistent results are needed to see the real therapeutic efficacy of MSC spheroids.…”
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    Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review
  16. 816
    “…The significant up-regulation of promoting EMT genes, ZEB1, TWIST1, E-cadherin and SNAIL1 in HT-29 spheroids (p-value = 0.03), SNAIL1 and Vimentin in Caco-2 spheroids (p-value < 0.05) and N-cadherin down-regulation in both spheroids were observed. …”
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    Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines
  17. 817
    “…Spontaneously formed spheroids from mouse compact bone-derived mesenchymal stromal cells (CB-MSCs) possess enhanced stemness and superior plasticity. …”
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    Cryopreserved Spontaneous Spheroids from Compact Bone-Derived Mesenchymal Stromal Cells for Bone Tissue Engineering
  18. 818
    “…Overall, we have established that cortical spheroids express ECS components and are thus a useful model for exploring endocannabinoid mediation of childhood neuropsychiatric disease.…”
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    CB(1) antagonism increases excitatory synaptogenesis in a cortical spheroid model of fetal brain development
  19. 819
    “…However, the duration of spheroid culture may influence the degree of correlation between these counterparts. …”
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    Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture
  20. 820
    “…The applied cyclic stretch protocol evoked an anabolic response and enhanced tendon-related marker expression in ACL-derived fibroblasts emigrating from 3D spheroids and seems also promising to support in future tissue formation in ACL scaffolds seeded in vitro with spheroids.…”
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    Cyclically stretched ACL fibroblasts emigrating from spheroids adapt their cytoskeleton and ligament-related expression profile
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