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881por Shield, Kristy, Riley, Clyde, Quinn, Michael A, Rice, Gregory E, Ackland, Margaret L, Ahmed, Nuzhat“…A significant proportion of ovarian cancer cells in peritoneal ascites exist as multicellular aggregates or spheroids. We hypothesize that these cellular aggregates or spheroids are invasive with the capacity to survive and implant on the peritoneal surface. …”
Publicado 2007
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882
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883por Laderoute, K. R., Murphy, B. J., Short, S. M., Grant, T. D., Knapp, A. M., Sutherland, R. M.“…Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. …”
Publicado 1992
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884“…The development of a serum-free, low-protein culture medium has allowed the detection of tumour-specific cytolytic cells in EMT6 immunized mice bearing EMT6 multicellular tumour spheroids. Spheroid associated (SAC) and peritoneal (PC) effector cells were specific to EMT6 as the target cell, not killing line 1, P815 or RIF-1. …”
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885“…Curves of growth delay (GD) or 'cure' after graded doses of radiation have been analysed for 16 lines of human and animal tumours grown as multicellular spheroids in vitro. Dose-survival curves were derived for those cellular units from which spheroids regrow after unsuccessful irradiation (spheroid-regenerating cellular units, SRU). …”
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886“…Compared to cells in a monolayer, spheroids were found to be highly resistant to combined heat and spermine. …”
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887por Monazzam, Azita, Josephsson, Raymond, Blomqvist, Carl, Carlsson, Jörgen, Långström, Bengt, Bergström, Mats“…The aim of this study was to introduce multicellular tumour spheroids (MTS) to study the effect of anticancer drugs and suggest an appropriate PET tracer for further studies. …”
Publicado 2007
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888“…The spheroids grew exponentially with a volume-doubling time of approximately 24 h up to a diameter of approximately 580 microns and then the growth rate tapered off, more for spheroids grown at the low than at the high oxygen tension. …”
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889“…In this study, we aimed to investigate the associations between COX-2, PGE(2) and NO in co-cultures of human colon cancer spheroids obtained from different tumor grades with normal human colonic epithelium and myofibroblast monolayers. …”
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890por Rademakers, Rosa, Baker, Matt, Nicholson, Alexandra M., Rutherford, Nicola J., Finch, NiCole, Soto-Ortolaza, Alexandra, Lash, Jennifer, Wider, Christian, Wojtas, Aleksandra, DeJesus-Hernandez, Mariely, Adamson, Jennifer, Kouri, Naomi, Sundal, Christina, Shuster, Elizabeth A., Aasly, Jan, MacKenzie, James, Roeber, Sigrun, Kretzschmar, Hans A., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Cairns, Nigel J., Ghetti, Bernardino, Spina, Salvatore, Garbern, James, Tselis, Alexandros C., Uitti, Ryan, Das, Pritam, Van Gerpen, Jay A., Meschia, James F., Levy, Shawn, Broderick, Daniel F., Graff-Radford, Neill, Ross, Owen A., Miller, Bradley B., Swerdlow, Russell H., Dickson, Dennis W., Wszolek, Zbigniew K.“…Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominantly inherited central nervous system white matter disease with variable clinical presentations including personality and behavioral changes, dementia, depression, parkinsonism, seizures, and others(1,2). …”
Publicado 2011
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891por Vinci, Maria, Gowan, Sharon, Boxall, Frances, Patterson, Lisa, Zimmermann, Miriam, Court, William, Lomas, Cara, Mendiola, Marta, Hardisson, David, Eccles, Suzanne A“…Moreover, mutual tissue invasion and angiogenesis is accommodated by coculturing tumor spheroids with murine embryoid bodies within which angiogenic differentiation occurs. …”
Publicado 2012
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892“…Toxicological analysis of these six compounds in 3D spheroid culture (either published or presented here) demonstrated similar LD(50) values. …”
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893
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894por Yamamoto, Hidekazu, Masters, John R., Dasgupta, Prokar, Chandra, Ashish, Popert, Rick, Freeman, Alex, Ahmed, Aamir“…Both monolayer- and spheroid-CFCs existed at a frequency of approximately 0.5% of total cells. …”
Publicado 2012
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895por Weegman, Bradley P., Nash, Peter, Carlson, Alexandra L., Voltzke, Kristin J., Geng, Zhaohui, Jahani, Marjan, Becker, Benjamin B., Papas, Klearchos K., Firpo, Meri T.Enlace del recurso
Publicado 2013
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896por Pettee, Krista M., Dvorak, Kaitlyn M., Nestor-Kalinoski, Andrea L., Eisenmann, Kathryn M.“…Multi-cellular spheroids are enriched in ascites of epithelial ovarian cancer (OvCa) patients. …”
Publicado 2014
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897por Trumpi, Kari, Egan, David A., Vellinga, Thomas T., Borel Rinkes, Inne H.M., Kranenburg, Onno“…Novel spheroid-type tumor cell cultures directly isolated from patients’ tumors preserve tumor characteristics better than traditionally grown cell lines. …”
Publicado 2015
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898por Lee, Bae Hoon, Kim, Myung Hee, Lee, Jae Ho, Seliktar, Dror, Cho, Nam-Joon, Tan, Lay Poh“…Taken together, our findings establish guidelines to control the formation of Huh7.5 cell spheroids in modified PEGDA based hydrogels. These spheroids may serve as models for applications such as screening of pharmacological drug candidates.…”
Publicado 2015
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899“…Various spheroid formation techniques have been widely developed for efficient and reliable 3-D cell culture research. …”
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900por Judée, Florian, Fongia, Céline, Ducommun, Bernard, Yousfi, Mohammed, Lobjois, Valérie, Merbahi, Nofel“…This work investigates the regionalized antiproliferative effects of plasma-activated medium (PAM) on colon adenocarcinoma multicellular tumor spheroid (MCTS), a model that mimics 3D organization and regionalization of a microtumor region. …”
Publicado 2016
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