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961por Liu, Xinyuan, Gündel, Beate, Li, Xidan, Liu, Jianping, Wright, Anthony, Löhr, Matthias, Arvidsson, Gustav, Heuchel, Rainer“…In the present work, we developed a 3D heterospecies spheroid model to study the microenvironmental interactions between tumor cells and stellate cells which can also be employed to test therapeutic regimens. …”
Publicado 2021
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962por Kapara, Anastasia, Findlay Paterson, Karla A., Brunton, Valerie G., Graham, Duncan, Zagnoni, Michele, Faulds, Karen“…Finally, we demonstrated how nanotag uptake by MCF-7 spheroids was affected by the drug fulvestrant, the first-in-class approved selective estrogen receptor degrader (SERD). …”
Publicado 2021
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963por Eilenberger, Christoph, Rothbauer, Mario, Selinger, Florian, Gerhartl, Anna, Jordan, Christian, Harasek, Michael, Schädl, Barbara, Grillari, Johannes, Weghuber, Julian, Neuhaus, Winfried, Küpcü, Seta, Ertl, Peter“…Despite the advances of spheroid models in pharmaceutical screening applications, variations in spheroid size and consequential altered cell responses often lead to nonreproducible and unpredictable results. …”
Publicado 2021
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964“…This study expands the scope of multicolor fluorescence microscopy by serial imaging of polystyrene micro-beads as surrogates for drug carriers, cancer spheroids formed using HeLa cells, and microfluidic channels. …”
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965“…However, in vitro 3D models (spheroids) have been proven to be superior in reflecting the tumor microenvironment. …”
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966por Chen, Oleg, Michlíková, Soňa, Eckhardt, Lisa, Wondrak, Marit, De Mendoza, Adriana M., Krause, Mechthild, McLeod, Damian D., Kunz-Schughart, Leoni A.“…For the first time, HT-induced radiosensitization was systematically examined in two differently radioresponsive HNSCC spheroid models using the unique in vitro “curative” analytical endpoint of spheroid control probability. …”
Publicado 2021
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967por Dyson, Paul JEnlace del recurso
Publicado 2019
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969por Ebner-Peking, Patricia, Krisch, Linda, Wolf, Martin, Hochmann, Sarah, Hoog, Anna, Vári, Balázs, Muigg, Katharina, Poupardin, Rodolphe, Scharler, Cornelia, Schmidhuber, Sabine, Russe, Elisabeth, Stachelscheid, Harald, Schneeberger, Achim, Schallmoser, Katharina, Strunk, Dirk“…Triple cell type floating spheroids formation was promoted by human platelet-derived growth factors containing culture conditions, using nanoparticle cell labelling for monitoring the organization process. …”
Publicado 2021
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970por Shujaa Edin, Hareth Y., AL-Haj, Nagi A., Rasedee, Abdullah, Banu Alitheen, Noorjahan, Abdul Kadir, Arifah, Wun How, Chee, Sulaiman Rahman, Heshu, AL-Shwyeh, Hussah Abdullah“…The main objective of this study was to investigate the effect of rHuEPO on the response of spheroid breast cancer, MCF-7, cells to tamoxifen treatment. …”
Publicado 2021
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971por Kotze, Leigh A., Beltran, Caroline G. G., Lang, Dirk, Loxton, Andre G., Cooper, Susan, Meiring, Maynard, Koegelenberg, Coenraad F. N., Allwood, Brian W., Malherbe, Stephanus T., Hiemstra, Andriette M., Glanzmann, Brigitte, Kinnear, Craig, Walzl, Gerhard, du Plessis, Nelita“…A range of manipulations of immune cell populations in these spheroid granulomas will allow the study of host/pathogen pathways involved in the outcome of infection, as well as pharmacological interventions. …”
Publicado 2021
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972por Hikage, Fumihito, Ichioka, Hanae, Watanabe, Megumi, Umetsu, Araya, Ohguro, Hiroshi, Ida, Yosuke“…This study indicates that ROCK‐is significantly and differently modulate physical properties of the 3D HOF spheroids as well as their adipogenesis.…”
Publicado 2021
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973por Gögele, Clemens, Hoffmann, Christina, Konrad, Jens, Merkel, Rudolf, Schwarz, Silke, Tohidnezhad, Mersedeh, Hoffmann, Bernd, Schulze-Tanzil, Gundula GesineEnlace del recurso
Publicado 2021
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974por Suga, Takenori, Usui, Michihiko, Onizuka, Satoru, Sano, Kotaro, Sato, Tsuyoshi, Nakazawa, Kohji, Ariyoshi, Wataru, Nishihara, Tatsuji, Nakashima, Keisuke“…A spheroid is known as a three-dimensional culture model, which better simulates the physiological conditions of stem cells. …”
Publicado 2021
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975por Shanbhag, Siddharth, Suliman, Salwa, Mohamed-Ahmed, Samih, Kampleitner, Carina, Hassan, Mohamed Nageeb, Heimel, Patrick, Dobsak, Toni, Tangl, Stefan, Bolstad, Anne Isine, Mustafa, Kamal“…BACKGROUND: Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D printing offers the possibility to produce customized scaffolds for complex bone defects. …”
Publicado 2021
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976por Deng, Junhao, Li, Miao, Meng, Fanqi, Liu, Zhongyang, Wang, Song, Zhang, Yuan, Li, Ming, Li, Zhirui, Zhang, Licheng, Tang, Peifu“…Therefore, in this study, we aimed to maintain those beneficial properties of MSC via three-dimensional spheroid cell culture and then compared them with conventionally-cultured MSCs in the treatment of SCI both in vitro and in vivo with the aid of two-photon microscope. …”
Publicado 2021
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977por Liu, Wen-Ming, Zhou, Xu, Chen, Cai-Yang, Lv, Dong-Dong, Huang, Wei-Jian, Peng, Yuan, Wu, Hong-Ping, Chen, Yi, Tang, Dan, Guo, Li-Na, Wang, Xiu-Li, Zhang, Hong-Dan, Liu, Xiao-Hua, Yang, Li-Qun, Yu, Wei-Feng, Yan, He-Xin“…Our results display the efficacy and safety of the alginate microencapsulated spheroids in animal model with acute liver injury (ALF), which may suggest a new strategy for cell therapy.…”
Publicado 2021
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978por Tuffin, Jack, Chesor, Musleeha, Kuzmuk, Valeryia, Johnson, Tim, Satchell, Simon C., Welsh, Gavin I., Saleem, Moin A.“…Here we report a rapidly generated and highly reproducible 3D co-culture spheroid model (GlomSpheres), better demonstrating the specialised physical and molecular structure of a glomerulus. …”
Publicado 2021
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979por Ali, Rizwan, Huwaizi, Sarah, Alhallaj, Alshaimaa, Al Subait, Arwa, Barhoumi, Tlili, Al Zahrani, Hajar, Al Anazi, Abdullah, Latif Khan, Abdul, Boudjelal, Mohamed“…There is an immense demand for highly efficient and easy methods to produce 3D spheroids in any cell format. We have developed a novel and easy method to produce spheroids from the newly isolated KAIMRC1 cell line in vitro. …”
Publicado 2021
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980por Martinez, Ramon, Huang, Weiliang, Buck, Heather, Rea, Samantha, Defnet, Amy E., Kane, Maureen A., Shapiro, Paul“…The current study uses high-resolution label-free mass spectrometry to compare relative protein changes in BRAF/MEK1/2 inhibitor-resistant A375 melanoma cells grown as monolayers or spheroids. While approximately 66% of proteins identified were common in the monolayer and spheroid cultures, only 6.2 or 3.6% of proteins that significantly increased or decreased, respectively, were common between the drug-resistant monolayer and spheroid cells. …”
Publicado 2022
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