“…At the same time, ADSC-spheroids retain similar morphology and microarchitecture in different culture conditions. …”
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“…Dermis models were characterized in terms of spheroid diameter, PICP release, collagen III and CD44 expression. …”
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“…The aim of the study was to compare the relevance of ovarian adenocarcinoma spheroids with that of a monolayer culture for assessing photodynamic effect of the tetrakis(4-benzyloxyphenyl)tetracyanoporphyrazine photosensitizer. …”
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“…Spheroidal corneal degeneration is predominantly seen in advanced age and hereditary predisposition to this disorder is very rare. …”
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“…Tumour spheroid experiments are routinely used to study cancer progression and treatment. …”
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“…SIMPLE SUMMARY: During metastasis, ovarian cancer spheroids move from the original tumor and travel through the abdominal cavity to other sites. …”
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“…Cancer cell spheroids are used for drug screening as these three-dimensional (3D) assemblies recapitulate tumors more realistic than the widely employed 2D in vitro cultures. …”
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“…RESULTS: We found that a small side population (SP) in OCM1 showed stem cell-like properties such as heterogeneity, remote dissemination and nuclear dye exclusion after spheroid formation in vitro. ZEB1 regulated UM stem cell generation indirectly by promoting cell proliferation to form large size tumors in vivo and spheroid in vitro, and directly by binding to stemness genes such as TERT and ABCB1. …”
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“…In our paper we propose new conditions between resonantly excited electric dipole and magnetic quadrupole in ceramic high index spheroidal particles for demonstrating transverse Kerker effect. …”
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“…Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. …”
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“…Finally, we demonstrated that curcumin reduces the size of DU145 and PC-3 3D cell spheroids and has the potential to induce apoptosis. …”
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“…Polyhedrons, spheroids and bolas (PSBs) are present in lithic series from the Lower Palaeolithic onwards and are found in several regions of the world. …”
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“…Here we show that the gradient field induced by the spheroid—accelerates cells’ invasion of the extracellular matrix. …”
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“…Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan’s classical study of the 1970 s through to contemporary agent-based models. …”
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“…Various methods have been developed to produce multicellular tumor spheroids (MCTSs), including scaffold-free and scaffold-based structures, which usually depend on the demands of the cells used and the related biological question. …”
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“…(ii) Both cell lines showed a decrease in the lifetime of o-Ps after spheroid generation on day 8 compared to day 4 in culture, and the mean o-Ps lifetime was longer for spheroids formed from WM115 cells than for those formed from WM266-4 cells, regardless of spheroid age. …”
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“…BACKGROUND/AIM: Serum and growth factor deprivation, a common cellular stressor in solid tumors, arises upon irradiation, chemotherapy, and antiangiogenesis. Spheroid body culture aims to enrich cancer stem cells by using low attachment conditions and some growth factors, such as basic fibroblast growth factor and epidermal growth factor to support the spheroid formation in serum-free spheroid culture. …”
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“…However, no previously published works on spheroids have specifically focused on keloids yet. …”
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“…However, efficient production of gut spheroids remains challenging due to a lack of control and mechanistic understanding of gut spheroid morphogenesis. …”
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