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  1. 1141
    “…When subjected to PIT, the spheroids showed a dose-dependent response with smaller spheroids (0.01 and 0.018 mm(3)) showing a complete response with no recurrence when treated with 100 J/cm(2). …”
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  2. 1142
    “…In 3D tumor cell models, IONP(DOX) were able to penetrate the cell spheroids towards the hypoxic areas. However, IONP(DOX) and 150 kV X-rays led to a dose-modifying factor DMF(SF=0.1) = 1.09 ± 0.1 (200 µg/mL IONP(DOX)) in HeLa spheroids, but to a radioprotective effect in FaDu spheroids. …”
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  3. 1143
  4. 1144
    “…Dynamic and static cell culture examinations were applied to monitor the growth of 3D cells. α-MG-loaded GA liposomes were used as the drug to test cell viability in 3D cancer spheroids. Two cell culture conditions (i.e., static and dynamic) were also used in drug testing to simulate the effect of flow on drug cytotoxicity. …”
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  5. 1145
  6. 1146
  7. 1147
    “…Furthermore, the results demonstrated that the 2D in vitro model overestimated the relative efficiency of the anticancer agents (i.e., nanozymes and the DOX drug) compared to the 3D spheroid models. These findings are notable as they evidenced that the 3D spheroid model resembles more precisely the TME of “real” brain cancer tumors in patients than 2D cell cultures. …”
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  8. 1148
    “…The 3D H9c2 spheroids were successfully obtained, the sizes of the spheroids decreased, and they became stiffer during 3–4 days. …”
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  9. 1149
  10. 1150
    “…To elucidate possible unknown biological indicators, these fibroblasts were subjected to a cellular metabolic analysis by a Seahorse bioanalyzer, in conjugation with 3D spheroid cultures of the cells and co-cultures with a pancreas ductal carcinoma cell line, MIA PaCa-2. …”
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  11. 1151
    “…The study involved human breast cancer (MCF-7) and colon cancer (HT-29) spheroids. The MCF-7 and HT-29 spheroids were treated with paclitaxel (Taxol; PTX) and the active metabolite of irinotecan SN-38, respectively. …”
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  12. 1152
  13. 1153
    “…The results show that EPT remarkably accelerated the spheroidizing of second phase (S phase) in the as-cast 2024 Al alloy. …”
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  14. 1154
    por Twentyman, P. R.
    Publicado 1982
    “…Experiments have been carried out to determine whether the growth delay induced in small EMT6 spheroids (approximately 250 micrometers in diameter) by a range of cytotoxic drugs can be increased by pre-incubation of the spheroids under hypoxic conditions with misonidazole (MISO). …”
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  15. 1155
    por Olive, P. L.
    Publicado 1995
    “…The possibility of using tirapazamine (SR 4233) to identify hypoxic cells in multicell spheroids and murine tumours was examined by measuring tirapazamine-induced DNA damage to individual cells from multicell spheroids and SCCVII murine tumours. …”
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  16. 1156
    “…METHODS: Chromosome 3 gene expression profiles (n = 1147 probe sets, representing 735 genes) were extracted from U133A expression microarray analyses of the EOC cell lines OV-90, TOV-21G and TOV-112D that were grown as monolayers, spheroids or nude mouse xenografts and monolayers derived from these tumors. …”
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  17. 1157
    “…A new nanocomposite architecture is reported which combines prolate spheroidal hematite nanoparticles with drug-carrying layered double hydroxide [LDH] disks in a single structure. …”
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  18. 1158
    por Kim, Heungnam, Phung, Yen, Ho, Mitchell
    Publicado 2012
    “…Here, we generated a matrix-free tumor spheroid model using the NCI-H226 mesothelioma cell line and compared the gene expression profiles of spheroids and monolayers using microarray analysis. …”
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  19. 1159
    “…The invasiveness of normal NNSC, GBM/CD133+ cell lines and GBM spheroids was evaluated in 3D collagen, as well as of U87-MG and normal astrocytes (NHA) grown in monolayers in 2D Matrigel. …”
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  20. 1160
    “…Cluster of differentiation (CD) 133(+) and spheroid formation have been reported to be one of the main features of ovarian CSCs. …”
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