“…The effectiveness of the spheroids to be recovered and grown under 2D culture conditions was evaluated. …”
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“…Human induced pluripotent stem cell (hiPSC)-derived brain spheroids can recapitulate the complex cytoarchitecture of the brain, as well as the genetic/epigenetic footprint of human brain development. …”
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“…A monovalent EGFR-targeted nanobody and biparatopic version modified with different dextran average molecular weights (1000, 5000, and 10,000) were probed for their ability to penetrate tumor spheroids. For monovalent Cy5-labeled dextraknobs, the utilization of smaller sized dextran (MW 5000 vs. 10,000) was found to be beneficial for more homogeneous penetration into A431 tumor spheroids over time. …”
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“…Retention of the stain in spheroids is sufficiently stable to allow cell sorting several hours post-injection. …”
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“…The O2 consumption in spheroids appears to decrease with increasing spheroid size under most of the growth conditions investigated. …”
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“…The myocardial cells in addition contain some SR cisternae deep within the cells which also possess opaque cores composed of spheroids. Although the significance of the junctional SR spheroidal bodies is unknown, it is thought that they could act as a matrix on which enzymes such as calcium-specific ATPase may be located.…”
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“…The increased complement resistance of tumour cells growing in three-dimensional spheroids is partly because of an insufficient penetration of antibodies and complement into the TMSs. …”
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“…Spheroid response to irradiation was evaluated as time to reach 10x treatment volume and proportion of spheroids sterilised. …”
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“…Spheroids derived from the human colon adenocarcinoma cell line, WiDr, were exposed to 10 micrograms ml-1 Photofrin II and irradiated with light (700 nm, 50 mW cm-2). …”
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“…An in vivo model has been established to study the role of macrophages in the initiation of angiogenesis by human breast tumour spheroids in vivo. The extent of the angiogenic response induced by T47D spheroids implanted into the dorsal skinfold chamber in nude mice was measured in vivo and compared to that induced by spheroids infiltrated with human macrophages prior to implantation. …”
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“…By growing multicellular spheroids in agarose gels of defined mechanical properties, we have recently shown that solid stress inhibits the growth of spheroids and that this growth-inhibiting stress ranges from 45 to 120 mmHg. …”
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“…Several different models have been suggested for the basic growth rate of in vitro tumor spheroids, and several different mechanisms are possible by which tumor necrosis factor might halt growth. …”
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“…We study BBB formation in a 3-dimensional multicellular spheroid system of human primary brain endothelial cells (hpBECs), primary pericytes (hpPs) and primary astrocytes (hpAs). …”
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“…Individual cells and multicellular aggregates, or spheroids, seed these metastases, both commonly found in ascites. …”
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“…When incubated with calcein-AM, a substrate of the efflux transporter P-glycoprotein (Pgp), spheroids from a variety of cell types accumulated calcein over time. …”
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“…BACKGROUND: Hereditary diffuse leukodystrophy with spheroids is a rare type of leukoencephalopathy. Mutations in the colony stimulating factor 1 receptor have recently been identified to be the cause of this microgliopathy. …”
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“…Here we provide a simple micro-plate method (based on uniform, self-assembling 3D tumor spheroids) which has great potential for such studies. …”
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“…Compared to cells in monolayers, 3D spheroids secreted also bFGF and showed MMP2 activity. …”
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“…Multicellular spheroids were embedded in collagen and introduced to the microchamber. …”
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