“…[Image: see text] We investigated diffusion of spheroidal molecules near a planar surface, accounting for spatially dependent translational and rotational mobilities of molecules resulting from their hydrodynamic interactions with the plane. …”
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“…The chip encapsulated cells in alginate and allowed cancer cells to grow for over seven days to form cancer spheroids. However, reagents or media used to screen drugs in a high-density spheroid array had to be replaced very carefully, and this was a tedious task. …”
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“…Here, we have developed functional islet spheroids using a microfluidic chip that mimics interstitial flow conditions with reduced shear cell damage. …”
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“…However, spheroid cell culture system has limitations such as hypoxia and necrosis in the spheroid core. …”
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“…Although cryopreservation methods for oocytes and embryos have been developed for use in reproductive medicine, there are no established methods yet for preserving cell aggregates (spheroids) in regenerative medicine. We have developed a bio-three-dimensional (3D) printer that can fabricate scaffold-free 3D constructs by loading spheroids onto a needle array. …”
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“…We describe a method for quantifying the contractile forces that tumor spheroids collectively exert on highly nonlinear three-dimensional collagen networks. …”
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“…Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and response to treatment of different cancer cell lines. …”
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“…The majority of currently available data have been obtained from 2D in vitro cultures, however, 3D cell culture systems (spheroids) are more likely to behave similarly to in vivo conditions. …”
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“…Spheroids positive for P-NF and NP-NF were detected. …”
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“…Here, we provide a comprehensive overview of 3D tumor systems and highlight the strategies for spheroid construction and evaluation tools of targeted therapies, focusing on their applicability in cancer research. …”
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“…Human serum high-density lipoproteins (HDLs) are a population of small, dense protein-lipid aggregates that are crucial for intravascular lipid trafficking and are protective against cardiovascular disease. The spheroidal HDL subfraction can be separated by size and density into five major subpopulations with distinct molecular compositions and unique biological functionalities: HDL(3c), HDL(3b), HDL(3a), HDL(2a) and HDL(2b). …”
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“…Tissue spheroids consist of a three-dimensional model of cells which is capable of imitating the complicated composition of healthy and unhealthy human tissue. …”
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“…The SMC spheroids were viable for up to 14 days and differentiated rather than proliferating. …”
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“…Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to their advantage in designing a three-dimensional (3D) solid tumor model. …”
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“…In this paper, the volume integral equation method (VIEM) is introduced for the numerical analysis of an infinite isotropic solid containing a variety of single isotropic/anisotropic spheroidal inclusions. In order to introduce the VIEM as a versatile numerical method for the three-dimensional elastostatic inclusion problem, VIEM results are first presented for a range of single isotropic/orthotropic spherical, prolate and oblate spheroidal inclusions in an infinite isotropic matrix under uniform remote tensile loading. …”
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“…Herein, we used image analysis to establish a link between human melanoma C8161 spheroid morphology and drug responsiveness. Spheroids were pre-selected based on sphericity, area, and diameter, reducing variation in experimental groups before treatment. …”
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“…Here we aim to give an overview of the different applications of NSCLC spheroids and discuss the potential contribution of the spheroid model to the development of anticancer strategies.…”
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“…This approach is based on the use of 3D tissue aggregates named spheroids and consisting of endothelial cells lining the inner surface of blood vessels, one or more other types of cells forming the vessel wall, and the extracellular matrix. …”
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