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  1. 1661
    “…Cell migration assay was determined using the scratch wound healing test. Spheroid formation was evaluated and the expression level of stem cell markers was investigated by western blot analysis. …”
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  2. 1662
    “…We hypothesized that the inclusion of peptide-based scaffold (PuraMatrix) in the spheroid matrix, to represent in vivo tumor microenvironment alterations along with metastatic site conditions, would enhance spheroid cell growth and migration and alter nanovector transport. …”
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  3. 1663
  4. 1664
    “…By enriching LCSCs from spheroid cultures and performing transcriptomic analysis, we determined that alanine–glyoxylate aminotransferase (AGXT), which participates in the metabolism of serine and glycine, was significantly upregulated in spheroid cultures, and its function in LCSCs remains unknown. …”
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  5. 1665
    “…Pulsed light stimulation of an immobilized spheroid was used to simulate the light fluctuation experienced by a rotating spheroid during phototaxis. …”
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  6. 1666
    “…We determined whether salivary gland-resident stem cells (SGSCs) are primed by a 3D spheroid culture prior to treating irradiation-induced salivary hypofunction using in-vitro coculture and in-vivo transplant models. …”
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  7. 1667
    “…Native or immortalized immune cells were added directly or 24 h post spheroid formation, and their infiltration was observed. …”
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  8. 1668
    “…Except for treosulfan, all nonplatinum treatments tested showed a lesser effect on tumor spheroids compared to that of platinum-based therapies. …”
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  9. 1669
  10. 1670
    por Folkman, Judah, Hochberg, Mark
    Publicado 1973
    “…Multi-cell spheroids were grown in soft agar. When each spheroid was cultured in a large volume of medium, frequently renewed, all spheroids eventually reached a dormant phase at a diameter of approximately 3–4 mm and a population of approximately 10(6) cells. …”
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  11. 1671
    por Budel, Leithe, Djabali, Karima
    Publicado 2017
    “…Multipotency was investigated by differentiation into adipocytes, smooth muscle cells and fibroblasts. The pH-SKP spheroid yield at day 5 was four- and threefold higher than those obtained using trypsin- and no-stress methods, respectively. …”
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  12. 1672
    por Dong, Ruochen, Chen, Ping, Chen, Qi
    Publicado 2018
    “…The pancreatic CSC population, identified using cell surface markers or a tumor spheroid formation assay, was significantly reduced, with an IC(50) value of ~100 µg/ml treatment for 48 h and ~27 µg/ml for long-term tumor spheroid formation. …”
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  13. 1673
  14. 1674
    “…DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. …”
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  15. 1675
  16. 1676
    “…DNER expression was increased upon stem cell-enriching cancer spheroid culture. Knockdown of DNER expression inhibited cell proliferation and invasion, induced apoptosis, enhanced chemosensitivity, and decreased spheroid formation of SNU-638 gastric cancer cells. …”
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  17. 1677
  18. 1678
    “…Siramesine caused tumor cell death and reduced secondary spheroid formation of patient-derived spheroid cultures. …”
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  19. 1679
  20. 1680
    “…In models in which liver spheroids and MRC-5 spheroids were co-cultured, we observed complex strand morphogenesis, whereby thin, linear, 3D liver cell strands attach to the MRC-5 spheroid, anchor and thicken to form permanent and thick anchoring contacts between the two spheroids. …”
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