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  1. 1861
    “…We used a quantitative real-time polymerase chain reaction to examine circ-Foxo3 expression in spheroids. RESULTS: Circ-Foxo3 expression was significantly downregulated in spheroid-forming tumor cells, according to our data. …”
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    Downregulation of circ-Foxo3 in breast cancer stem-like cells
  2. 1862
    “…Further, remote photothermal irradiation accelerates degradation inside cancer cells in a tumor spheroid model, with efficiency correlating with the endocytosis progression state of the nanoparticles. …”
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    Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation
  3. 1863
    “…Drug combination screen using a custom-made library of 88 compounds in association with six inhibitors of the identified glioblastoma vulnerabilities was performed to unveil pharmacological synergisms. Glioblastoma 3D spheroid, organotypic ex vivo and syngeneic orthotopic mouse models were used to validate synergistic treatments. …”
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    Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms
  4. 1864
    “…CD98hc-positive radiation-resistant cell lines exhibited enhanced spheroid formation, invasion, and plating efficiency as well as strong tumorigenicity in nude mice. …”
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    CD98hc as a marker of radiotherapy-resistant cancer stem cells in head and neck squamous cell carcinoma
  5. 1865
    “…At this stage, the tumor reaches a maximum diameter characteristic of an avascular tumor spheroid. The endothelial cells in the pre-existing vasculature respond to the pro-angiogenic factors both by chemotaxing towards higher concentrations of pro-angiogenic factors and by forming new blood vessels via angiogenesis. …”
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    3D Multi-Cell Simulation of Tumor Growth and Angiogenesis
  6. 1866
    “…METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that the transcription factor Snail, a key regulator of epithelial-mesenchymal transition, is induced in a reactive oxygen species (ROS)-dependent manner in both two-dimensional culture of cancer cells, including A549, HepG2, and MDA-MB-231, in response to GD and the inner regions of a multicellular tumor spheroid system, an in vitro model of solid tumors and of human tumors. …”
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    Implication of Snail in Metabolic Stress-Induced Necrosis
  7. 1867
    por Selz, Karen A.
    Publicado 2011
    “…These two behavioral shape-states, spheroid and ellipsoid, are generally recognized as making up the vocabulary of a healthy PMN. …”
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    A Third Measure-Metastable State in the Dynamics of Spontaneous Shape Change in Healthy Human's White Cells
  8. 1868
    “…After implantation in collagen-I gels, Minitumour spheroids form quantifiable endothelial capillary-like structures. …”
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    A Heterogeneous In Vitro Three Dimensional Model of Tumour-Stroma Interactions Regulating Sprouting Angiogenesis
  9. 1869
    “…Interestingly, erlotinib also prevents spontaneous multicellular tumour spheroid growth in U87MG cells and cooperates with sub-optimal doses of temozolomide (TMZ) to reduce multicellular tumour spheroid growth. …”
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    EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth
  10. 1870
    por Meng, F, Sun, G, Zhong, M, Yu, Y, Brewer, M A
    Publicado 2013
    “…RESULTS: Combination treatment had greater efficacy than single drugs and significantly suppressed cell viability, migration, and spheroid formation and growth. Sequential treatment of cisplatin (1 mg kg(−1)) followed by TSA (0.3 mg kg(−1)) significantly suppressed tumorigenicity of HEY xenografts through inhibition of EMT and decreased pluripotency of ovarian cancer cells. …”
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    Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2′-deoxycytidine on ovarian cancer
  11. 1871
    “…Cancer stem cell (CSC)-associated assays, including expression of self-renewal and CSC marker genes, proliferation, differentiation, spheroid formation, chemotherapy resistance, and tumorigenicity were then conducted between SP and non-SP (NSP) LSCCs. …”
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    Identification of Cancer Stem-Like Side Population Cells in Purified Primary Cultured Human Laryngeal Squamous Cell Carcinoma Epithelia
  12. 1872
    “…We observed under serum monolayer conditions, that nestin positive or nestin and SMA double positive rat stromal cells outgrew EGFR amplified tumor cells, while serum spheroid cultures preserved tumor cells with EGFR amplification. …”
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    Tumor versus Stromal Cells in Culture—Survival of the Fittest?
  13. 1873
    “…The effect of Lipo-DS on the NFκB pathway, CSCs and chemosensitivity was investigated in vitro and in vivo. The spheroid cultured BC cells manifested CSC characteristics and pan-resistance to anticancer drugs. …”
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    Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo
  14. 1874
    “…RESULTS: Ovarian CSC-LCs obtained through spheroid culture showed irregularly elongated appearance, CD24 negative, and OCT4 and SOX2 positive. …”
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    IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation
  15. 1875
    por Lee, Doohyung, Lee, Jung Weon
    Publicado 2015
    “…The TM4SF5/CD44 interaction activated c-Src/STAT3/ Twist1/ B mi1 signaling for spheroid formation, while disturbing the interaction, expression, or activity of any component in this signaling pathway inhibited spheroid formation. …”
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    Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44
  16. 1876
    “…The anticancer drugs reduced spheroid migration velocity and suppressed spheroid fusion. …”
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    Time-lapse imaging assay using the BioStation CT: A sensitive drug-screening method for three-dimensional cell culture
  17. 1877
    “…CD80 expression in tumor-spheroid infiltrating mPGES-1(−/−) macrophages translated into antigen-specific cytotoxic T cell activation. …”
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    MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
  18. 1878
    “…Inhibiting mDia suppressed directional migration and spheroid invasion while preserving intrinsic random migration. mDia agonism abrogated both random intrinsic and directional migration and halted U87 spheroid invasion in ex vivo brain slices. …”
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    Small-molecule agonists of mammalian Diaphanous–related (mDia) formins reveal an effective glioblastoma anti-invasion strategy
  19. 1879
    “…Fluvial, lacustrine and aeolian ‘red beds’ contain widespread centimetre-scale reduction spheroids in which a pale reduced spheroid in otherwise red rocks contains a metalliferous core. …”
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    Metalliferous Biosignatures for Deep Subsurface Microbial Activity
  20. 1880
    “…The degree of tumor eccentricity was estimated by using the difference between the spheroid tumor volume and ellipsoid tumor volume (spheroid-ellipsoid discrepancy, SED). …”
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    The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in Breast Cancers
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