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  1. 1901
    “…TC71, CHLA9, PANC1, YOU and HEYA8 cell lines were grown as tumor spheroids in polyHEMA coated plates. Temporal profiling of transcriptomic alterations over 72 hrs was used to develop a comprehensive PM model. …”
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    Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition
  2. 1902
    “…Secondly, in order to recapitulate the in vivo tumor architecture, we tested various doses of these compounds, alone and in combination, in the 3D multicellular spheroid culture. The effect of combination of dichloracetate and salinomycin on multicellular spheroid size was stronger than the sum of both monotherapies, particularly in HCT116 cells. …”
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    Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines
  3. 1903
    “…In the 3D multicellular spheroid, loss of p53 consistently reduced collective cellular migration into surrounding collagen matrix. …”
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    The tumor suppressor p53 can promote collective cellular migration
  4. 1904
    “…This study also uncovers the previously unknown role of the inhibition of CTNNB1 signaling as a novel candidate to decrease the tumorigenesis of glioma spheroids and subsequent spheroid growth. The accurate and precise biostatistics results were obtained at quantify level. …”
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    Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
  5. 1905
    “…This study introduces, efficiency chondrogenic differentiation of fetal cartilage-derived progenitor cells (FCPCs) to adult cells can be achieved using a three-dimensional (3D) spheroid culture method based on silica nanopatterning techniques. …”
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    Development of three-dimensional articular cartilage construct using silica nano-patterned substrate
  6. 1906
    “…The synthesized Cu(II) complexes, as well as the corresponding uncoordinated ligands, were evaluated for their cytotoxic activity in monolayer and 3D spheroid cancer cell cultures with different Pt(II)-sensitivity. …”
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    Syntheses and Biological Studies of Cu(II) Complexes Bearing Bis(pyrazol-1-yl)- and Bis(triazol-1-yl)-acetato Heteroscorpionate Ligands
  7. 1907
    “…Method: We describe a highly integrated approach to establish an in vitro model of chemoresistance and stemness in ovarian cancer, using the 3D hanging drop spheroid platform. The model was established by serially passaging non-adherent spheroids. …”
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    Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance
  8. 1908
    “…The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of menthol-modified casein nanoparticles (M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. …”
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    Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy
  9. 1909
    “…CONCLUSIONS: Our study demonstrates the unfavourable prognostic role of MAN1A1 in ovarian cancer, probably caused by an altered ability of spheroid formation, and the strong influence of this glycosylation enzyme on the prognostic impact of ALCAM.…”
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    Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation
  10. 1910
    “…We isolated two populations of 3D tumor spheroids displaying CSC-like features from breast carcinoma (MCF-7) and lung carcinoma (A549) cell lines. …”
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    Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs
  11. 1911
    “…Quantitative and reliable measurement of cellular invasion is important to understand a range of biological processes such as cancer metastasis and angiogenesis. Spheroid invasion assays are an attractive in vitro platform because they effectively mimic the tumor cell invasion of solid tissues. …”
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    Novel invasion indices quantify the feed-forward facilitation of tumor invasion by macrophages
  12. 1912
    “…To the best of our knowledge, 3D tissue constructs have been biofabricated for the first time in space under microgravity from tissue spheroids consisting of human chondrocytes. Bioassembly and sequential tissue spheroid fusion presented a good agreement with developed predictive mathematical models and computer simulations. …”
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    Magnetic levitational bioassembly of 3D tissue construct in space
  13. 1913
    “…CD44v6/v9(+/+) cells were sorted from EBVaGC cell line (SNU719) cells and EBV‐infected TMK1 cells and these cell populations showed high spheroid‐forming ability and tumor formation in SCID mice compared with the respective CD44v6/v9(−/−) cells. …”
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    Cancer stem cells in Epstein‐Barr virus‐associated gastric carcinoma
  14. 1914
    “…OVCAR-8 cells with LOC642852 KO were significantly less motile and less invasive compared to controls, with no differences in spheroid formation, proliferation, or matrix metalloproteinase (MMP) activity. …”
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    The Biological and Clinical Role of the Long Non-Coding RNA LOC642852 in Ovarian Carcinoma
  15. 1915
    “…Moreover, CD83 functions through the activation of MAP3K7-MEK1/2-ERK1/2 cascades to further regulate downstream FOXO1/p21/CDK2/CCNB1 and STAT3/DKK1 signaling pathways, thus activating proliferation and spheroid formation of ovarian cancer cells, respectively. …”
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    CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate
  16. 1916
    “…Invasion, migration and cell proliferation were determined using spheroid invasion, Boyden chambers and scratch assay, and XTT metabolic assays for cell growth. …”
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    Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth
  17. 1917
    “…The mathematical model incorporates some often-understated features and mechanisms of traditional spheroid systems such as cell-specific oxygen uptake, media volume, spheroid size, and well dimensions that can lead to a spatially heterogeneous distribution of oxygen. …”
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    Mathematical modelling of oxygen gradients in stem cell-derived liver tissue
  18. 1918
    “…Our results demonstrated that RBF can inhibit the proliferation, migration, and tube formation of HUVECs in a dose-dependent manner. Spheroid sprouts were thinner and shorter after RBF treatment in vitro 3D spheroid sprouting assay. …”
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    Resibufogenin Suppresses Triple-Negative Breast Cancer Angiogenesis by Blocking VEGFR2-Mediated Signaling Pathway
  19. 1919
    “…Herein, we present a platform to study the tumour-immune interaction using a co-culture between cancer spheroids and activated immune cells. An algorithm was developed for analysis of confocal images of the co-culture to evaluate the following quantitatively; immune cell infiltration, spheroid roundness and spheroid growth. …”
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    An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model
  20. 1920
    “…Proliferation, migration, invasiveness, adhesion, spheroid formation, and survival tests were performed. …”
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    Analysis of the Role of FRMD5 in the Biology of Papillary Thyroid Carcinoma
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