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  1. 1921
    “…Cell transformation was tested using focus formation due to loss of contact inhibition of cell proliferation, and colony formation was examined on soft agar and spheroid formation in ultralow U‐bottomed wells. DynAPa robustly formed foci and colonies on soft agar and spheroid, whereas these abilities were considerably decreased for dynAPb and completely lost in dynAPc. …”
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    Expression and cell transformation activity of dynactin‐associated protein isoforms
  2. 1922
    “…In the present study, we showed increased expression of TRIB2 in spheroid-forming and aldehyde dehydrogenase-positive CSC populations of A2780 epithelial ovarian cancer cells. …”
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    TRIB2 Stimulates Cancer Stem-Like Properties through Activating the AKT-GSK3β-β-Catenin Signaling Axis
  3. 1923
    “…Under ex vivo three-dimensional (3D) culture conditions, the DDCS2 cells produced spheroid patterns similar to the well-established CS-1 and SW1353 chondrosarcoma cell lines. …”
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    Establishment and Characterization of a Novel Dedifferentiated Chondrosarcoma Cell Line DDCS2
  4. 1924
    “…In fibrin assays, HMOs and 3’SL increased total tube length by 24% and 25% (p < 0.05), in spheroid assays, by 32% (p < 0.05) and 21% (p = 0.056), respectively. …”
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    Human Milk Oligosaccharides in Cord Blood Are Altered in Gestational Diabetes and Stimulate Feto-Placental Angiogenesis In Vitro
  5. 1925
    “…Further tests using the 3D multicellular tumor spheroid model suggested that deficiency in ABCB1 restrained tumor spheroid growth and restore sensitivity to paclitaxel in MDR tumor spheroids. …”
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    Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells
  6. 1926
    “…The present study evaluated the effects of TTFields with different duty cycles on glioma spheroid cells and normal brain organoids. A customized TTFields system was developed to perform in vitro experiments with varying duty cycles. …”
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    Effect of duty cycles of tumor-treating fields on glioblastoma cells and normal brain organoids
  7. 1927
    por Yang, Ben, Wang, Fengling, Zheng, Gang
    Publicado 2021
    “…Wound healing, transwell invasion, mammary spheroid formation, and ALDH activity were performed to detect the effects of TMEM119. …”
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    Transmembrane protein TMEM119 facilitates the stemness of breast cancer cells by activating Wnt/β-catenin pathway
  8. 1928
    “…The encapsulated cells demonstrated good viability and grew into tumor spheroids in 12–14 days. Single cell-laden hydrogel microspheres were also obtained and grown into spheroid in 14 days. …”
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    One-Step Generation and Purification of Cell-Encapsulated Hydrogel Microsphere With an Easily Assembled Microfluidic Device
  9. 1929
    “…DNA double-strand breaks were evaluated in the spheroid experiments, and HCT116 GFP cell xenograft tumours in mice were used to investigate the effect of nitazoxanide and radiation in vivo. …”
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    Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
  10. 1930
    “…Effects of PAH on stem cell characteristics of PC-3 cells were evaluated by cell-matrix adhesion assay, colony formation assay, spheroid formation assay, as well as western blot . …”
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    Perillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines
  11. 1931
    “…Tumor cell growth features including cell proliferation, colony/spheroid formation, migration and invasion were documented. …”
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    Comparison of growth features and cancer stem cell prevalence in intrahepatic and extrahepatic cholangiocarcinoma cell lines
  12. 1932
    “…Validation was performed using three-dimensional anaplastic thyroid carcinoma cell cultures (spheroids) in order to more closely recapitulate in vivo drug response. …”
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    Utilizing Three-Dimensional Culture Methods to Improve High-Throughput Drug Screening in Anaplastic Thyroid Carcinoma
  13. 1933
    “…Surface loading of ZnCl(2) on spheroid TiO(2) nanoparticles is evident in the case of the ZnCl(2) loaded TiO(2) sample. …”
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    ZnCl(2) loaded TiO(2) nanomaterial: an efficient green catalyst to one-pot solvent-free synthesis of propargylamines
  14. 1934
    “…HMN-214 significantly inhibits cell cycle regulator CDK1 and the phosphorylation and activation of PLK1 in NB. In the NB 3D spheroid tumor model, HMN-214 significantly and in a dose-dependent manner inhibits spheroid tumor mass and growth. …”
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    Inhibition of Polo-like Kinase 1 by HMN-214 Blocks Cell Cycle Progression and Inhibits Neuroblastoma Growth
  15. 1935
    “…By combining parallel measurements of T cell behaviors and tumor fates with probabilistic modeling, we establish that the first recruited T cells initiate a positive feedback loop to accelerate further recruitment to the spheroid. We also provide evidence that cooperation between T cells on the spheroid during the killing phase facilitates tumor destruction. …”
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    High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing
  16. 1936
    “…Moreover, MIM-seq could slightly reduce the growth of our spheroid models, especially under serum-deprivation. …”
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    A Micro-Immunotherapy Sequential Medicine MIM-seq Displays Immunomodulatory Effects on Human Macrophages and Anti-Tumor Properties towards In Vitro 2D and 3D Models of Colon Carcinoma and in an In Vivo Subcutaneous Xenograft Colon Carcinoma Model
  17. 1937
    “…We employed immunohistochemistry and a three-dimensional (3D) spheroid ex vivo assay to determine the best treatment option for this case. …”
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    Temozolomide and Capecitabine Treatment for an Aggressive Somatotroph Pituitary Tumor: A Case Report and Literature Review
  18. 1938
    “…We identified the embryonic protein CRIPTO in stem cell-enriched spheroid cultures of adenocarcinoma (AC) and squamous cell carcinoma (SCC) derived from NSCLC surgical specimens. …”
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    CRIPTO Is a Marker of Chemotherapy-Induced Stem Cell Expansion in Non-Small Cell Lung Cancer
  19. 1939
    “…Then, we generate a 3D vascularized tumor model by combining a tumor heterotypic spheroid, consisting of fibroblasts and Malignant Pleural Mesothelioma (MPM) cells, with the surrounding vascular ring. …”
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    Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing
  20. 1940
    “…FKA treatment significantly decreased both the size and numbers of the tumor spheroids over different generations of spheroid passages. …”
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    Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer
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