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  1. 1
    “…This Brief introduces SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), the different synthesis approaches, their applications in the field of diagnostics and treatment and finally as theranostic agents in cancer.…”
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    Spions as nano-theranostics agents
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    “…Easy preparation of SPIONs with the controllable, well-defined properties is a key factor of their practical application. …”
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    Online Artículo Texto
    Easy Synthesis and Characterization of Holmium-Doped SPIONs
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    “…The results showed a successful synthesis of 190 nm sized particles and their stable coating, resulting in SPION(HAp). Potential cytotoxic effects of SPION(HAp) on EL4, THP-1, and Jurkat cells were tested, showing only a minor effect on cell viability at the highest tested concentration (400 µg Fe/mL). …”
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    Hydroxyapatite-Coated SPIONs and Their Influence on Cytokine Release
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    “…The optimal total polymer concentration in the prior-drying SPION dispersion, which enables the formation of an easily dispersible electrospun product with high SPION-loading (65% (w/w)) and fibrillar morphology, was shown to be 4.2% (w/v).…”
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    Influence of Polymer Concentration on Drying of SPION Dispersions by Electrospinning
  5. 5
    “…The importance of protein-SPION interaction and various safety considerations relating to SPION exposure are also addressed.…”
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    Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
  6. 6
    “…BACKGROUND: In the present investigation, we studied the kinetics and biodistribution of a contrast agent consisting of poly(vinyl alcohol) (PVA) microbubbles containing superparamagnetic iron oxide (SPION) trapped between the PVA layers (SPION microbubbles). …”
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    Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat
  7. 7
    “…X-ray diffraction (XRD) analysis was performed to further confirm the success of the combination of modified SPIONs and PHBV. Thermogravimetric analysis (TGA) indicated that PHBV microspheres were incorporated with SPIONs(Lauric) as compared with SPIONs(Oleic). …”
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    Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
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    “…Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. …”
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    SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?
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    “…Results: We showed, for the first time, uptake of uncoated SPIONs (uSPIONs) by hiPSC-ECs. In comparison with mature ECs of identical genetic background hiPSC-ECs showed lower uSPION uptake. …”
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    The Effect of Uncoated SPIONs on hiPSC-Differentiated Endothelial Cells
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    “…In this study, graphene oxide (GO) is decorated by superparamagnetic iron oxide nanoparticles (SPION) (GO/SPION) as well as polyethylene glycol functionalized SPION (GO/SPION@PEG), and chitosan functionalized SPION (GO/SPION@CS). …”
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    Functionalized SPION immobilized on graphene-oxide: Anticancer and antiviral study
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    Publicado 2009
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    Spion van al-Qaida werkte aan deeltjesversneller bij CERN
  12. 12
    “…MATERIALS AND METHODS: In this study, we used SPIONs coated with 3-aminopropyltriethoxysilane (APTES) and functionalized with a peptide originating from GP340 (SPION-APTES-Pep). …”
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    Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs
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    “…For this reason, HumAfFt was successfully used in this study as a coating material for 10 nm SPIONs, in order to produce a new magnetic nanocarrier able to discriminate cancer cells from normal cells and maintain the potential theragnostic properties of SPIONs. …”
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    Ferritin-Coated SPIONs as New Cancer Cell Targeted Magnetic Nanocarrier
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    “…For bench to bedside translation of super-paramagnetic iron oxide nanoparticles (SPIONs), safety issues have to be comprehensively clarified. …”
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    Flow cytometry for intracellular SPION quantification: specificity and sensitivity in comparison with spectroscopic methods
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    “…However, the surface hydrophilicity of superparamagnetic iron oxide nanoparticles (SPIONs) usually leads to poor or even failed encapsulation of SPIONs in hydrophobic polymer microspheres using the emulsion method. …”
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    Facile preparation of multifunctional superparamagnetic PHBV microspheres containing SPIONs for biomedical applications
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    “…The MB uptake by macrophages is promoted by SPION labelling, in particular external such, which may be important for macrophage targeting.…”
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    Cellular Uptake of Plain and SPION-Modified Microbubbles for Potential Use in Molecular Imaging
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    SPION Conjugated Curcumin Nano-Imaging Probe: Synthesis and Bio-Physical Evaluation
  18. 18
    “…Superparamagnetic iron oxide nanoparticles (SPIONs) have been investigated for wide variety of applications. …”
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    Bioevaluation of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with dihexadecyl phosphate (DHP)
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    “…At the cellular level, SPION uptake, along with SPION-mediated toxicity, represents the most important prerequisite for successful application. …”
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    Cellular SPION Uptake and Toxicity in Various Head and Neck Cancer Cell Lines
  20. 20
    “…SPIONs and latex coated SPIONs (PL-Sp) were used in batch adsorption study for effective removal of Methylene blue (MB) dye, where (PL-Sp) removed MB dye effectively. …”
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    Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery
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