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Mostrando 21 - 40 Resultados de 126 Para Buscar '"Spock"', tiempo de consulta: 0.14s Limitar resultados
  1. 21
    “…Our findings, together with the functional relevance, strongly supported that the SPOCK gene underlies variation of AAM.…”
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    Genome-Wide Association Analyses Identify SPOCK as a Key Novel Gene Underlying Age at Menarche
  2. 22
    “…Metastasis is a crucial impediment to the successful treatment for gastric cancer. SPOCK1 has been demonstrated to facilitate cancer metastasis in certain types of cancers; however, the role of SPOCK1 in the invasion and metastasis of gastric cancer remains elusive. …”
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    SPOCK1 promotes the invasion and metastasis of gastric cancer through Slug‐induced epithelial‐mesenchymal transition
  3. 23
    “…The pathway and functional enrichment analyses of the present study allowed for the identification of modules 1 and 2, and their respective genes, SPARC (osteonectin), cwcv and kazal like domain proteoglycan 1 (SPOCK1) and kruppel like factor 6 (KLF6), which were involved in the occurrence of OSF. …”
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    Network-based identification of signature genes KLF6 and SPOCK1 associated with oral submucous fibrosis
  4. 24
    por Chen, Jie, Ye, Ziqi, Liu, Lulu, Xuan, Bixia
    Publicado 2022
    “…The study of the prognostic value of SPOCK1 in ccRCC is a good complement to the study of ccRCC biomarkers. …”
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    Assessment of the prognostic value of SPOCK1 in clear cell renal cell carcinoma: a bioinformatics analysis
  5. 25
    por Spock, Benjamin, 1903-1998
    Publicado 1971
    Libro
    Decent and indecent: our personal and political behaviour
  6. 26
    “…The present study aims to explore the possible role of SPOCK2 in the pathogenesis of PDAC. MATERIALS AND METHODS: Expression of SPOCK2 was evaluated in 7 PDAC cell lines and 1 normal pancreatic cell line using quantitative RT-PCR. …”
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    SPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer
  7. 27
    “…Transcriptomic analysis of EPCR-silenced tumors unveiled an effect mediated by matricellular secreted proteoglycan SPOCK1/testican 1. Interestingly, SPOCK1 silencing suppressed in vitro 3D growth. …”
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    EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth
  8. 28
    “…The aim of the present study was to determine the effect of microRNA (miR)-155-5p on the expression of testican-1 (SPOCK1) and the invasion and migration of prostate cancer cells in vitro. …”
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    MicroRNA-155-5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1
  9. 29
    “…SPOCK1 is highly expressed in many types of cancer and has been recognized as a promoter of cancer progression. …”
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    SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling
  10. 30
    “…Expression profiles were confirmed in an independent breast cancer cohort for both BOC and SPOCK2. In addition, differential overexpression of SPOCK2 and GJD3 mRNA levels were found to be associated with the development of brain metastasis in an external online database of 204 primary breast cancers. …”
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    Differential Expression of BOC, SPOCK2, and GJD3 Is Associated with Brain Metastasis of ER-Negative Breast Cancers
  11. 31
    “…Then, SPOCK2 silence was implemented to search functions of SPOCK2 in OC cells. …”
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    SPOCK2 Promotes the Malignant Behavior of Ovarian Cancer via Regulation of the Wnt/β-Catenin Signaling Pathway
  12. 32
    “…In the present study, we explored the role of SPOCK1 in CRC. Our results demonstrated that SPOCK1 is overexpressed in CRC cell lines. …”
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    Knockdown of SPOCK1 Inhibits the Proliferation and Invasion in Colorectal Cancer Cells by Suppressing the PI3K/Akt Pathway
  13. 33
    “…The relationship between EZH2 and SPOCK2 or SPRED1 was confirmed by dual-luciferase reporter assay. …”
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    SPOCK2 and SPRED1 function downstream of EZH2 to impede the malignant progression of lung adenocarcinoma in vitro and in vivo
  14. 34
    “…PCa cells were transfected with either Snail-, Slug-, SPOCK1-overexpressing vector, or small hairpin (sh)SPOCK1 to determine the invasive abilities and expression levels of SPOCK1 and epithelial-to-mesenchymal transition (EMT) biomarkers in response to API treatment. …”
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    Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis
  15. 35
    por Liu, Gang, Ren, Fang, Song, Yongsheng
    Publicado 2019
    “…BACKGROUND: It is known that secreted protein acidic and cysteine rich (osteonectin), cwcv and kazal-like domains proteoglycan 2 (SPOCK2) plays a significant role in the development and progression of several human cancers; however, the role of SPOCK2 in prostate cancer (PCa) remains unclear. …”
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    Upregulation of SPOCK2 inhibits the invasion and migration of prostate cancer cells by regulating the MT1-MMP/MMP2 pathway
  16. 36
    “…The oncogenic role of SPARC/osteonectin, cwcv, and kazal-like domain proteoglycan 1 (SPOCK1) has been demonstrated in several cancers, however, the clinical and functional significance of SPOCK1 in PTC are largely unknown. …”
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    MON-536 SPOCK1 Promotes the Progression of Papillary Thyroid Cancer ViaPI3K/Akt Signaling Activation
  17. 37
    “…Our findings revealed miR-135b might target Spock1. Upregulation of SPOCK1 correlated with advanced stages of CRCs. …”
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    Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids
  18. 38
    “…By combining the analysis of the expression dataset from RNA-seq and scRNA-seq, SPOCK2, STX11, and ZNF331 were highlighted in CPAM. …”
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    Integrated bulk and single-cell RNA-sequencing reveals SPOCK2 as a novel biomarker gene in the development of congenital pulmonary airway malformation
  19. 39
    “…We found that TGF-β induced SPOCK1 expression in MCF10A, MCF12A, and M10 breast cells and demonstrated SPOCK1 as a novel myoepithelial marker that was immunolocalized within or beneath myoepithelia lining ductolobular units. …”
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    SPOCK1 Is a Novel Transforming Growth Factor-β–Induced Myoepithelial Marker That Enhances Invasion and Correlates with Poor Prognosis in Breast Cancer
  20. 40
    por van Boven, Job FM, Kaplan, Alan G
    Publicado 2016
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    Hollywood raising awareness of smoking-related diseases: can it proactively counteract the impact of smoking in movies?—the final mission of Star Trek’s Mr Spock
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