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61por Li, Zhenchong, Ma, Zuyi, Zhou, Qi, Wang, Shujie, Yan, Qian, Zhuang, Hongkai, Zhou, Zixuan, Liu, Chunsheng, Wu, Zhongshi, Zhao, Jinglin, Huang, Shanzhou, Zhang, Chuanzhao, Hou, Baohua“…RESULTS: Four candidate genes (LCN2, SLC6A14, SPOCK1, and VCAN) were selected to establish a four-gene signature for PC. …”
Publicado 2022
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62por Chung, Woonbok, Kwabi-Addo, Bernard, Ittmann, Michael, Jelinek, Jaroslav, Shen, Lanlan, Yu, Yinhua, Issa, Jean-Pierre J.“…The combination of NSE1 or SPOCK2 hypermethylation showed a sensitivity of 80% and specificity of 95% in differentiating cancer from normal. …”
Publicado 2008
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63por Chen, Huan, Gu, Xiao-hong, Zhou, Yuxi, Ge, Zeng, Wang, Bin, Siok, Wai Ting, Wang, Guoqing, Huen, Michael, Jiang, Yuyang, Tan, Li-Hai, Sun, Yimin“…The SPOCK1 gene is located on chromosome 5q31.2 and encodes a highly conserved glycoprotein testican-1 which was associated with tumor progression and prognosis as well as neurogenesis. …”
Publicado 2017
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64por Nolan, Daniel K, Sutton, Beth, Haynes, Carol, Johnson, Jessica, Sebek, Jacqueline, Dowdy, Elaine, Crosslin, David, Crossman, David, Sketch, Michael H, Granger, Christopher B, Seo, David, Goldschmidt-Clermont, Pascal, Kraus, William E, Gregory, Simon G, Hauser, Elizabeth R, Shah, Svati H“…RESULTS: We identified four genes with SNPs that showed the strongest and most consistent associations with LDL-C and CAD: EBF1, PPP2R2B, SPOCK1, and PRELID2. The most significant results for association of SNPs with LDL-C were: EBF1, rs6865969, p = 0.01; PPP2R2B, rs2125443, p = 0.005; SPOCK1, rs17600115, p = 0.003; and PRELID2, rs10074645, p = 0.0002). …”
Publicado 2012
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65por Cranmer, Miles, Tamayo, Daniel, Rein, Hanno, Battaglia, Peter, Hadden, Samuel, Armitage, Philip J., Ho, Shirley, Spergel, David N.“…Our inference model is publicly available in the SPOCK (https://github.com/dtamayo/spock) package, with training code open sourced (https://github.com/MilesCranmer/bnn_chaos_model).…”
Publicado 2021
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66por Marimuthu, Arivusudar, Jacob, Harrys K.C., Jakharia, Aniruddha, Subbannayya, Yashwanth, Keerthikumar, Shivakumar, Kashyap, Manoj Kumar, Goel, Renu, Balakrishnan, Lavanya, Dwivedi, Sutopa, Pathare, Swapnali, Dikshit, Jyoti Bajpai, Maharudraiah, Jagadeesha, Singh, Sujay, Sameer Kumar, Ghantasala S, Vijayakumar, M., Veerendra Kumar, Kariyanakatte Veeraiah, Premalatha, Chennagiri Shrinivasamurthy, Tata, Pramila, Hariharan, Ramesh, Roa, Juan Carlos, Prasad, T.S.K, Chaerkady, Raghothama, Kumar, Rekha Vijay, Pandey, Akhilesh“…Pathway analysis led to the identification of several networks in which SPOCK1 was among the topmost networks of interacting genes. …”
Publicado 2011
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67“…Among these intersection genes, CA9, EBI3, SPOCK2, WDFY4, CD1D, and CCL22 were significantly correlated with overall survival in PDAC patients. …”
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68por Ji, Xuanrui, Pei, Quanwei, Zhang, Junpei, Lin, Pengqi, Li, Bin, Yin, Hongpeng, Sun, Jingmei, Su, Dezhan, Qu, Xiufen, Yin, Dechun“…We identified the core co-expressed genes (SPOCK2, CTSZ, HLA-DMB, ALDOA, SFRP1, ERBB3) and the pathways that function in them (Complement and coagulation cascades, HIF-1 signaling pathway, JAK-STAT signaling pathway), and finally localized their key cellular subgroups (T_cells subgroup, Microglia subgroup, Macrophage subgroup, Astrocyte subgroup, and Oligodendrocytes subgroup). …”
Publicado 2023
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69por Chai, Tianci, Tian, Mengyue, Yang, Xiaojie, Qiu, Zhihuang, Lin, Xinjian, Chen, Liangwan“…MR analysis showed that circulating ECM1, SPOCK3 and IL1b levels were associated with AAD. …”
Publicado 2022
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70por Li, Feng, Song, Qing-Zhen, Zhang, Yi-Fan, Wang, Xing-Ru, Cao, Li-Min, Li, Nan, Zhao, Ling-Xia, Zhang, Sheng-Xiao, Zhuang, Xiao-Fei“…Results: A six-gene EMT signature (PMEPA1, LOXL2, PLOD2, MMP14, SPOCK1 and DCN) was successfully constructed and validated. …”
Publicado 2022
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71“…Of which, six optimal genes were included to construct Risk Score, comprising FOXJ1, EPO, FGF5, SPOCK1, KCNF1 and PSG5. High risk LC patients had significantly poorer overall survival than low risk patients. …”
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72por He, Chungang, Huang, Qinyuan, Zhong, Shibiao, Chen, Li Sheng, Xiao, Hewei, Li, Lei“…Five hypermethylated genes including ZNF471, SND1, SPOCK1, FBLIM1, and OTX1 were detected and confirmed in 68 cases of colorectal cancer, 31 cases of adenoma, and 49 cases of normal control group. …”
Publicado 2023
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73por Fan, Zirong, Zheng, Jian, Xue, Yixue, Liu, Xiaobai, Wang, Di, Yang, Chunqing, Ma, Jun, Liu, Libo, Ruan, Xuelei, Wang, Zhenhua, Liu, Yunhui“…Western blot assay was used to determine the expression levels of NR2C2, SPOCK1, and NR2C2-uORF in glioma tissues and cells. …”
Publicado 2018
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74“…Among epigenetic biomarkers, most reports indicate GSTP1 hypermethylation as the diagnostic marker for prostate cancer; however, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS, and NSE1 also have been reported to be regulated by methylation mechanisms in prostate cancer. …”
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75por Fukuchi, Satoshi, Homma, Keiichi, Sakamoto, Shigetaka, Sugawara, Hideaki, Tateno, Yoshio, Gojobori, Takashi, Nishikawa, Ken“…The Genomes TO Protein Structures and Functions (GTOP) database (http://spock.genes.nig.ac.jp/~genome/gtop.html) freely provides an extensive collection of information on protein structures and functions obtained by application of various computational tools to the amino acid sequences of entirely sequenced genomes. …”
Publicado 2009
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76“…The underlying mechanisms of CHD1L activation may disrupt the cell death program via binding the apoptotic protein Nur77 or through activation of the AKT pathway by up-regulation of CHD1L-mediated target genes (e.g., ARHGEF9, SPOCK1 or TCTP). CHD1L is now considered to be a novel independent biomarker for progression, prognosis and survival in several solid tumors. …”
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77por Wang, Lei-Yun, Cui, Jia-Jia, Zhu, Tao, Shao, Wei-Hua, Zhao, Yi, Wang, Sai, Zhang, Yu-Peng, Wu, Ji-Chu, Zhang, Le“…The Gene Expression Omnibus dataset were used and a total of 41 genes were found significantly differently expressed in tumor tissues as compared with normal prostate tissues. Four genes (SPOCK3, SPON1, PTN and TGFB3) were selected for further evaluation after Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis and clinical association analysis. …”
Publicado 2017
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78“…PPI network analysis identified 10 hub genes: VCAM1, FHL2, RUNX1, TNFSF10, PLAU, SPOCK1, CD74, SIPA1L2, TRIB1, and CXCL12. Through bioinformatic analysis, we identified potential biomarkers and therapeutic targets for aortic stenosis, providing a theoretical basis for future studies.…”
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79por Zhong, Jun, Krawczyk, Sarah A., Chaerkady, Raghothama, Huang, Hailiang, Goel, Renu, Bader, Joel S., Wong, G. William, Corkey, Barbara E., Pandey, Akhilesh“…They include collagen triple helix repeat containing 1, cytokine receptor-like factor 1, glypican-1, hepatoma-derived growth factor, SPARC related modular calcium binding protein 1, SPOCK 1, and sushi repeat-containing protein. A bioinformatics analysis using Human Protein Reference Database and Human Proteinpedia revealed that of the 420 proteins identified, 164 proteins possess signal peptides and 148 proteins are localized to the extracellular compartment. …”
Publicado 2010
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80Mesoscopic Interactions and Species Coexistence in Evolutionary Game Dynamics of Cyclic Competitionspor Cheng, Hongyan, Yao, Nan, Huang, Zi-Gang, Park, Junpyo, Do, Younghae, Lai, Ying-Cheng“…By extending the RPS game model to five (rock-paper-scissors-lizard-Spock, or RPSLS) mobile species, we uncover a fundamental type of mesoscopic interactions among subgroups of species. …”
Publicado 2014
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