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81“…The Rock-Paper-Scissors (RPS) game of three species and its extensions [e.g., the Rock-Paper-Scissors-Lizard-Spock (RPSLS) game] are paradigmatic models in this field. …”
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82por Dai, Bai, Hao, Fei, Xu, Teng, Zhu, Bing, Ren, Li-Qing, Han, Xiao-Yu, Liu, Dong-Jun“…Through comprehensive analysis, we selected Thymosin β4 (Tβ4), Rho GTPase activating protein 6 (ARHGAP6), ADAM metallopeptidase with thrombospondin type 1 motif 15, (ADAMTS15), Chordin (CHRD), and SPARC (Osteonectin), cwcv and kazal-like domains proteoglycan 1 (SPOCK1) as candidate genes. Gene set enrichment analysis (GSEA) for these genes revealed Tβ4 and ARHGAP6 have a close association with the growth and development of SHF-DPCs. …”
Publicado 2020
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83por Vega-Benedetti, Ana Florencia, Loi, Eleonora, Moi, Loredana, Orrù, Sandra, Ziranu, Pina, Pretta, Andrea, Lai, Eleonora, Puzzoni, Marco, Ciccone, Letizia, Casadei-Gardini, Andrea, Cabras, Francesco, Fortunato, Federica, Restivo, Angelo, Zorcolo, Luigi, Scartozzi, Mario, Zavattari, Patrizia“…Furthermore, we analysed expression levels of selected genes whose promoter CGIs were hypermethylated in CRC, detecting downregulation at mRNA and protein levels in CRC tissue for GRIA4, VIPR2, SPOCK1 and SLC6A3. Most of these genes were already lowly expressed in colon normal tissues supporting the idea that cancer DNA methylation targets genes already barely expressed in the matched normal tissues. …”
Publicado 2020
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84por Wu, Jianwen, Xiao, Jing, Bai, Min, Shi, Chunli, Xin, Yunzhuo, Zhao, Wei, Gao, Xiaoping, Yin, Mei, Zhao, Jiaqing“…Furthermore, T follicular helper 2 (Tfh2) cells with high expression of Cxxc5 and Spock2 were found in E. granulosus-infected mice. …”
Publicado 2023
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85por Sanchez-Cabrero, Darío, Garcia-Guede, Álvaro, Burdiel, Miranda, Pernía, Olga, Colmenarejo-Fernandez, Julián, Gutierrez, Laura, Higuera, Oliver, Rodriguez, Isabel Esteban, Rosas-Alonso, Rocío, Rodriguez-Antolín, Carlos, Losantos-García, Itsaso, Vera, Olga, De Castro-Carpeño, Javier, Ibanez de Caceres, Inmaculada“…Our bioinformatics approach identified KPNA4 and SPOCK1 as potential miR-124 targets in NSCLC. miR-124 levels can be used to identify early-stage NSCLC patients at higher risk of relapse.…”
Publicado 2023
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86por Xia, Qiaoxi, Du, Zepeng, Chen, Mantong, Zhou, Xiao, Bai, Wenjing, Zheng, Xiaoqi, Lin, Ling, Zhao, Yan, Ding, Jiyu, Wu, Zhisheng, Zou, Haiying, Wang, Shaohong, Xu, Liyan, Li, Enmin, Wu, Bingli“…In addition, the LCN2/LOXL2/MMP9 ternary complex promoted the expression of testican‐1 (SPOCK1), and abnormally activated the FAK/AKT/GSK3β signalling pathway. …”
Publicado 2023
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87“…We built recombinant DNA with fragments of the selected “marker” genes in 1p (E2F2, NOTCH2), and 19q (PLAUR) and “reference” genes (ERC2, SPOCK1, and SPAG16 ) and used it as quantification standard in real-time PCR to gain absolute ratios of marker/reference gene copy numbers in tumor DNA samples, thus called comparative quantitative PCR (CQ-PCR). …”
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88por Pahl, Matthew C., Erdman, Robert, Kuivaniemi, Helena, Lillvis, John H., Elmore, James R., Tromp, Gerard“…Quantitative PCR assays confirmed a sub-set of the transcription factor binding sites including those in MTMR11, DUSP10, ITGAM, MARCH1, HDAC8, MMP14, MAGI1, THBD and SPOCK1.…”
Publicado 2015
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89por Zhang, Lei, An, Xiao-Peng, Liu, Xiao-Rui, Fu, Ming-Zhe, Han, Peng, Peng, Jia-Yin, Hou, Jing-Xing, Zhou, Zhan-Qin, Cao, Bin-Yun, Song, Yu-Xuan“…We speculated that ADCY8, VCAN, SPOCK1, THBS1, and THBS2 may play important roles in the development of endometrial receptivity. …”
Publicado 2015
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90por Yang, Min, Chen, Bo-Lin, Huang, Jian-Bao, Meng, Yan-Ni, Duan, Xiao-Jun, Chen, Lu, Li, Lin-Rui, Chen, Yan-Ping“…Levels of THBS1, MMP8, MMP9, MMP25, TIMP2 and TIMP3 increased as severity of BPD and retinopathy of prematurity (ROP) increased, whereas ETS1, LEF1 and SPOCK2 exhibited the opposite trend. Expression of ETS1 and LEF1 had a fitting rate of R(2) = 0.849 and P < 0.001. …”
Publicado 2017
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91por Petővári, Gábor, Tóth, Gábor, Turiák, Lilla, L. Kiss, Anna, Pálóczi, Krisztina, Sebestyén, Anna, Pesti, Adrián, Kiss, András, Baghy, Kornélia, Dezső, Katalin, Füle, Tibor, Tátrai, Péter, Kovalszky, Ilona, Reszegi, Andrea“…LX2-derived EVs induced over tenfold upregulation of SPOCK1/testican-1 in hepatoma EV cargo. We also identified liver cancer-specific miRNAs in hepatoma EVs, with potential implications for early diagnosis. …”
Publicado 2023
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92“…RESULTS: We screened six feature genes (AGRN, PHF13, SPOCK2, TGFBI, COL4A3, and COLQ) to construct an SLE diagnostic model. …”
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93por Delgado, Ivan J, Kim, Dong Sun, Thatcher, Karen N, LaSalle, Janine M, Van den Veyver, Ignatia B“…These comparisons identified a candidate MeCP2 target gene, SPOCK1, downregulated in two independent microarray experiments, but its expression was not altered by quantitative RT-PCR analysis on brain tissues from a RTT mouse model. …”
Publicado 2006
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94“…More interestingly, the following novel candidate genes were identified: Akap7, Akt1, Camk2d, Cckbr, Cd44, Crim1, Ctdsp2, Dnajc5, Gnai1, Itpka, Mapk8, Nbea, Nfatc3, Nlk, Npy5r, Phf21a, Phip, Ppm1l, Ppp1r1b, Rbbp4, Slc1a3, Slit2, Socs2, Spock3, St8sia1, Zfp207. Whether all these novel candidates indeed function in OD plasticity remains to be established, but possible roles of some of them are discussed in the article.…”
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95“…Selected novel genes further validated by qRT-PCR, protein expression analysis, and/or cellular localization included SPOCK2, PLEKHO1, SPRED1, RAB11FIP1, PTRF/CAVIN-1 and RAP1GAP. …”
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96“…CONCLUSIONS: RASSF2, RUNX3, GSTZ1, CYP2A, GBGT1, NDUFS1, SPOCK2, ADAM22, and TRIM36 were candidate genes for malignant transformation of ovarian EMS and epigenetic inactivation of RASSF2 by promoter hypermethylation is an early event in malignant transformation of ovarian EMS. …”
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97por You, Hye Jin, Park, Ho-Young, Kim, Jinkuk, Lee, In-Hee, Seol, Ho Jun, Lee, Jung-Il, Kim, Sung Tae, Kong, Doo-Sik, Nam, Do-Hyun“…Integrating analysis using gene expression based on the change of copy number revealed that SPOCK1, EHD2, SLC2A3, and ANXA11 were highly expressed with the gain of copy number, compared with the gene expression in the non-LMD group. …”
Publicado 2016
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98“…RESULTS: Among the 27 candidate genes tested, we confirmed 15 differentially methylated genes in cancer (15 DMGs; ER, SFRP1, MYOD1, MGMT, CD8a, SPOCK2, ABHD9, BNIP3, IGFBP3, WIF1, MAL, GDNF, ALX4, DOK5, and SLC16A12) in comparison to ADJ samples. …”
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99por Dolebo, Asrat Tera, Khayatzadeh, Negar, Melesse, Aberra, Wragg, David, Rekik, Mourad, Haile, Aynalem, Rischkowsky, Barbara, Rothschild, Max F., Mwacharo, Joram M.“…The genes associated with female reproduction traits included SPOCK1 (age at first oestrus), GPR173 (mediator of ovarian cyclicity), HB-EGF (signalling early pregnancy success) and SMARCAL1 and HMGN3a (regulate gene expression during embryogenesis). …”
Publicado 2019
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100“…Other genes important in the context of cytoskeleton (BMP4, CCL11, CUX2, DUSP7, FAM92B, GRIN2B, HOXA1, HOXA10, KIF20A, NF2, SPOCK1, TTR, UHRF1, and WT1), metabolism (MTHFD2), or correlation with WWOX (COL3A1, KIF20A, RNF141, and RXRG) were also discovered. …”
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